2,2′,4,4′‐Tetrabromodiphenyl ether and cadmium co‐exposure activates aryl hydrocarbon receptor pathway to induce ROS and GSDME‐dependent pyroptosis in renal tubular epithelial cells
Yating Sheng,
Chengpeng Zhang,
Dandan Cai
et al.
Abstract:We have previously found that a mixture exposure of 2,2′,4,4′‐tetrabromodiphenyl ether (BDE‐47) and cadmium (Cd) causes kidney damage; however, the mechanism was not fully understood. The aryl hydrocarbon receptor (AhR) is a ligand–receptor transcription factor that plays an important role in the adaptive response or metabolic detoxification of environmental toxins. Thus, this study aimed to examine the role of AhR in kidney toxicity. BDE‐47 (50 μM) or Cd (5 μM) exposure reduced cell viability in renal tubular… Show more
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