2,2,2-Trifluoroethanol as Green Solvent in Organic Synthesis: A Review

Dandia, Anshu; Singh, Ruby; Joshi, Jyoti; Kumari, Sukhbeer

doi:10.2174/1570193x1104140926170237

Cited by 29 publications

(22 citation statements)

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“…Conducting the AuPPh 3 Cl/AgOTf-catalyzed reaction in trifluoroethanol (TFE) led to improved results producing 8a in up to 97% yield ( Table 1 , entry 6). Thus, this greener alternative [ 63 ] to chlorinated solvents was selected as the solvent of choice for the further exploration. Changing the silver counterpart to AgPF 6 did not affect the reaction outcome yielding 8a in 96% ( Table 1 , entry 7).…”

Section: Resultsmentioning

confidence: 99%

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

Du¹,

Huang²,

Nechaev³

et al. 2018

Beilstein J. Org. Chem.

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Section: Resultsmentioning

confidence: 99%

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

Du¹,

Huang²,

Nechaev³

et al. 2018

Beilstein J. Org. Chem.

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“…Suitable solvents for MCRs are alcohols such as methanol and ethanol, water [ 123 , 124 , 125 ] and ionic liquids (ILs) [ 126 , 127 , 128 , 129 , 130 , 131 ], PEG-based ILs [ 132 ]. Unconventional solvents [ 133 ] such as trifluoroethanol [ 134 ] were also investigated. Solvent-free MCRs [ 135 , 136 ] also provide good results.…”

Section: Multicomponent Reactions (Mcrs)mentioning

confidence: 99%

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Eckert

2017

Molecules

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Several novel methods, catalysts and reagents have been developed to improve organic synthesis. Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multicomponent reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with ‘classical’ two-component reactions, fulfilling the rules of Green Chemistry. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-made and extremely low-cost materials, drugs and compound libraries.

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“…Unconventional solvents [135] such as trifluoroethanol [136] were also investigated. Solvent-free MCRs [137,138] also provide good results.…”

Section: Scheme 10 Postcondensation Cyclisations (Pccs) Of An Ugi-rementioning

confidence: 99%

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Eckert

2017

Preprint

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Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multi-component reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with 'classical' two-component reactions. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-made and extremely low-priced materials, drugs and libraries.Keywords: multicomponent reaction; MCR; post condensation modification PCM; post condensation cyclisation PCC; MFCR; multifunction catalysis; variability; diversity; complexity; efficiency of synthesis. PrologueThe high discrepancy between traditional feasibility mania and rational efficiency assessment in chemical synthesis became immediately apparent to the author while working on his thesis and during everyday laboratory life. On the one hand, classic peptide synthesis with an inefficient, extremely high number of synthesis steps and on the other hand, elegant multicomponent reactions that can make such efforts unnecessary. This double strategy in chemical synthesis has given the author cause to reflect (Picture 2) on how to close this gap using a consistent procedure. Picture 2. Problem in chemical syntheses relating to terms of producibility, ecology and economy.

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2,2,2-Trifluoroethanol as Green Solvent in Organic Synthesis: A Review

Cited by 29 publications

References 0 publications

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

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2,2,2-Trifluoroethanol as Green Solvent in Organic Synthesis: A Review

Cited by 29 publications

References 0 publications

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)&mdash;The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

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Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules