2-(2-(2-Hydroxybenzyliden) Hydrazinyl)-2-Oxo-N-(Pyridine-2-Yl) Acetamide Complexes: Synthesis, Characterization and Biological Studies

Abstract

Citation: El-Reash YGA, Zaky R, Yaseen MA (2016) 2-(2-(2-Hydroxybenzyliden) Hydrazinyl)-2-Oxo-N-(Pyridine-2-Yl) Acetamide Complexes: Synthesis, Characterization and Biological Studies. Chem Sci J 7: 145. doi: 10.4172/2150-3494.1000145 Copyright: © 2016 El-Reash YGA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Keywords: Hydrazones; DFT; DND; Potentiometry IntroductionHydrazones are versatile ligands and possessing an azomethine -NHN=CH-proton groups. They can be described by the following general structure R 2 C = NNR 2 . Hydrazone ligands and their metal complexes were attracted many authors because of their varied applications in biological, pharmaceutical, analytical, catalytic [1][2][3][4][5] and industrial fields. Hydrazones and their coordination compounds play important roles in treatment of different diseases. Hydrazones considered as an significant class of compounds with wide importance due to their various biological applications such as anticonvulsant, analgesic, antidepressant, antimalarial, antiplatelet, antimycobacterial, antimicrobial, antiviral, anticancer, antidiabetic, vasodilator, anthelmintic,. This work targets the synthesize and characterization Co(II) and Ni(II) complexes of 2-(2-(2-hydroxybenzyliden) hydrazinyl)-2-oxo-N-(pyridine-2-yl) acetamid (H 2 L). The geometry and modes of chelation of complexes were discussed based on the resulted (DFT) quantum calculations, the magnetic moment, the different spectroscopic methods ( 1 H and 13 C-NMR, UV-visible, IR, EI-mass). Moreover, the thermal decomposition steps were studied and both the kinetics and thermodynamic factors were determined using Coats-Redfern and Horowitz-Metzger models. In addition, potentiometric titrations were done in 50% DMSO-water mixture at various temperatures (298, 308 and 318 K) respectively. Moreover, their Minimum inhibitory concentration (MIC) and DNA-binding affinity assay were tested. (C, H and N) percent presented in the prepared ligand (H 2 L) and complexes were detected using a Perkin-Elmer 2400 series II analyzer, while chloride and metal contents determined using standard methods reported previously [15]. A thermogravimetric analyzer (TGA-50H) from Shimadzu, Japan, used for both thermogravimetric (TGA) and differential thermal analysis (DTA) measurements with a heating rate of 10°C/min on at temperature range (20-800°C) and nitrogen flow rate of 15 ml/min. A Sherwood Magnetic Balance was utilized to measure the magnetic susceptibility of solid complexes. A Mattson 5000 FTIR spectrophotometer was used to analyze the prepared ligand and complexes under range of (4000-400 cm -1 ) in KBr discs. While; the electronic spectra of complexes (in DMSO solution) was recorded using a Perkin Elmer Lamda 25 UV/Vis Spectrophotometer. 1 H, 13 C-NMR measurements were done on Mercury and Gemini 400 MHZ spectrome...

Synthesis, structural investigations, and in vitro biological activity of Co(II) and Fe(III) mixed ligand complexes of 1,10‐phenanthroline and 2,2′‐bipyridine

“…Accordingly, our present report aimed at the design of drugs based on the nature as well as interesting properties of metals such as the accessibility of different oxidation states along with the nature of the ligand in order to solve the aforesaid limitations. Mixed‐ligand complexes of cobalt(II) and iron(III) are particularly well suited to these systematic investigations due to their great redox potential and compatibility with physiological conditions, with bioactive ligands such as 2,2′‐bipyridine (Altaf et al, 2015), 1,10‐phenanthroline (Bencini & Lippolis, 2010; El‐Shwiniy et al, 2020), and acetamide (Abou El Reash & Zaky, 2016; Kerridge, 1988; Figure 1).…”