2.1 GHz electromagnetic field does not change contractility and intracellular Ca<sup>2+</sup>transients but decreases β-adrenergic responsiveness through nitric oxide signaling in rat ventricular myocytes

Olğar, Yusuf; Hidişoğlu, Enis; Celen, Murat Cenk; Yamasan, Bilge Eren; Yargiçoğlu, Pi̇raye; Özdemir, Semir

doi:10.3109/09553002.2015.1068462

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Additionally, the enhanced activity of voltage-gated calcium channels (VGCCs) have been delineated, after exposure to EMR in many cell types (94)(95)(96). Previous studies used the activity of VGCCs as an indicator of microwave radiation induced changes in ion channels (96,97). The level of neurotransmitters can indicate the membrane properties, such as the expression level of synaptic vesicular-associated proteins, can indicate the function of the synaptic vesicular membrane (22,98).…”

Section: Cell Membrane Damagementioning

confidence: 99%

Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain

Zuo

2021

Front. Public Health

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With the rapid development of electronic information in the past 30 years, technical achievements based on electromagnetism have been widely used in various fields pertaining to human production and life. Consequently, electromagnetic radiation (EMR) has become a substantial new pollution source in modern civilization. The biological effects of EMR have attracted considerable attention worldwide. The possible interaction of EMR with human organs, especially the brain, is currently where the most attention is focused. Many studies have shown that the nervous system is an important target organ system sensitive to EMR. In recent years, an increasing number of studies have focused on the neurobiological effects of EMR, including the metabolism and transport of neurotransmitters. As messengers of synaptic transmission, neurotransmitters play critical roles in cognitive and emotional behavior. Here, the effects of EMR on the metabolism and receptors of neurotransmitters in the brain are summarized.

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Section: Cell Membrane Damagementioning

confidence: 99%

Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain

Zuo

2021

Front. Public Health

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“…Olgar et al found that EMF of 2.1 GHz does not change the contractility and intracellular Ca2+ transients but decreases β-adrenergic responsiveness through NO signaling in rat ventricular myocytes while EMF exposure led to a signifi cant increase in NO levels in rat heart (47). A study by Zhu et al, showed that an exposition to 2450 MHz for 20 min caused an edema in myocardial cells, malalignment in muscle fi bers, obvious injury in cells, and signifi cant increase in expression of Caspase-3 and HSP 70 protein in EMR group (48).…”

Section: Tab 3 the Effects Of Melatonin And 2450 Mhz Emr On Malondimentioning

confidence: 99%

The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin

Gümral¹,

Saygın²,

Aşçı³

et al. 2017

BLL

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OBJECTIVE: This study was designed to investigate the effects of 2450 MHz EMR on the heart and blood in rat and possible ameliorating effects of melatonin. MATERIAL AND METHOD: Thirty-two female Wistar Albino rats were randomly grouped (by eight in each group) as follows: Group I: cage-control group (dimethysulfoxide (DMSO), 10mg/kg/day i.p. without stress and EMR. Group II: sham-control rats stayed in restrainer without EMR and DMSO (10mg/kg/day i.p.). Group III: rats exposed to 2450 MHz EMR. Group IV: treated group rats exposed to 2450 MHz EMR+melatonin (MLT) (10mg/kg/day i.p.). RESULTS: In the blood tissue, there was no signifi cant difference between the groups in respect of erythrocytes GSH, GSH-Px activity, plasma LP level and vitamin A concentration (p > 0.05). However, in the Group IV, erythrocytes' LP levels (p < 0.05) were observed to be signifi cantly decreased while plasma vitamin C, and vitamin E concentrations (p < 0.05) were found to be increased when compared to Group III. In the heart tissues, MDA and NO levels signifi cantly increased in group III compared with groups I and II (p < 0.05). Contrary to these oxidant levels, CAT and SOD enzyme activities decreased signifi cantly in group III compared with groups I and II (p < 0.05) and increased in group IV compared with group I, however not signifi cantly (p > 0.05). Besides, MLT treatment lowered the MDA and NO levels compared with group III. DISCUSSION: In conclusion, these results demonstrated that contrary to its effect on the heart, the wireless (2450 MHz) devices cause slight oxidative-antioxidative changes in the blood of rats, and a moderate melatonin supplementation may play an important role in the antioxidant system (plasma vitamin C and vitamin E). However, further investigations are required to clarify the mechanism of action of the applied 2450 MHz EMR exposure (Tab. 3, Fig. 1, Ref. 49). Text in PDF www.elis.sk. KEY WORDS: 2450 MHz electromagnetic radiation, heart and blood of rat, oxidant-antioxidant system, melatonin.

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Ultra-High-Frequency Electromagnetic Radiation and Reactive Species in Mammals

Furtado-Filho

2017

Microwave Effects on DNA and Proteins

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2.1 GHz electromagnetic field does not change contractility and intracellular Ca²⁺transients but decreases β-adrenergic responsiveness through nitric oxide signaling in rat ventricular myocytes

Abstract: Long-term exposure to 2.1 GHz EMF decreases β-AR responsiveness of ventricular myocytes through NO signaling.

Cited by 5 publications

References 28 publications

Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain

Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain

The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin

Ultra-High-Frequency Electromagnetic Radiation and Reactive Species in Mammals

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2.1 GHz electromagnetic field does not change contractility and intracellular Ca2+transients but decreases β-adrenergic responsiveness through nitric oxide signaling in rat ventricular myocytes

Abstract: Long-term exposure to 2.1 GHz EMF decreases β-AR responsiveness of ventricular myocytes through NO signaling.

Cited by 5 publications

References 28 publications

Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain

Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain

The effects of electromagnetic radiation (2450 MHz wireless devices) on the heart and blood tissue: role of melatonin

Ultra-High-Frequency Electromagnetic Radiation and Reactive Species in Mammals

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Product

Resources

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2.1 GHz electromagnetic field does not change contractility and intracellular Ca²⁺transients but decreases β-adrenergic responsiveness through nitric oxide signaling in rat ventricular myocytes