1α-Hydroxyvitamin D2 Is Less Toxic but Not Bone Selective Relative to 1α-Hydroxyvitamin D3 in Ovariectomized Rats

Weber, Karin; Goldberg, Michel; Stangassinger, M.; Erben, Reinhold G.

doi:10.1359/jbmr.2001.16.4.639

Cited by 24 publications

(9 citation statements)

References 47 publications

(116 reference statements)

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“…Although the results of clinical trials have been ambiguous, studies in rats have shown clearly that active vitamin D metabolites can fully prevent estrogen deficiency-induced loss of cancellous and cortical bone by suppression of bone resorption. (21)(22)(23)(24) At higher doses, vitamin D metabolites are bone anabolic and increase osteoblast team performance by augmenting osteoblast activity and proliferation of osteoblast precursors. (23)(24)(25)(26)(27) The aim of this study was to compare the efficacy of risedronate and of the naturally occurring vitamin D hormone 1␣,25-dihydroxyvitamin D 3 (calcitriol), alone or in combination, for the prevention of ovariectomy-induced bone loss in rats.…”

Section: Introductionmentioning

confidence: 99%

“…(21)(22)(23)(24) At higher doses, vitamin D metabolites are bone anabolic and increase osteoblast team performance by augmenting osteoblast activity and proliferation of osteoblast precursors. (23)(24)(25)(26)(27) The aim of this study was to compare the efficacy of risedronate and of the naturally occurring vitamin D hormone 1␣,25-dihydroxyvitamin D 3 (calcitriol), alone or in combination, for the prevention of ovariectomy-induced bone loss in rats. The data provided by this experiment indicate that combined therapy with bisphosphonates and calcitriol may offer advantages over the treatment with bisphosphonates or calcitriol alone.…”

Section: Introductionmentioning

confidence: 99%

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Prevention of Bone Loss in Ovariectomized Rats by Combined Treatment With Risedronate and 1α,25-Dihydroxyvitamin D3

Erben

Mosekilde²,

Thomsen³

et al. 2002

Journal of Bone and Mineral Research

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Bisphosphonates inhibit bone loss through inhibition of osteoclast-mediated bone resorption. At low doses, vitamin D metabolites can prevent bone loss in models of osteopenia in rats by an antiresorptive effect, while at high doses they also stimulate osteoblast activity and show an anabolic effect. Therefore, combined therapy with bisphosphonates and vitamin D analogs might be expected to be more effective than either treatment alone.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevention of Bone Loss in Ovariectomized Rats by Combined Treatment With Risedronate and 1α,25-Dihydroxyvitamin D3

Erben

Mosekilde²,

Thomsen³

et al. 2002

Journal of Bone and Mineral Research

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“…These results agree with a study in which OVX rats treated with 1α(OH)D 2 had increased total bone mineral density and Tb.N in the tibia relative to OVX rats [35]. Higher Tb.BMD, BV/TV and Tb.Th and lower BS/BV in NPM mice compared with OVX mice are also in agreement with another study in which nonirradiated Pleurotus mushroom extracts were shown to alleviate the decrease in Tb.BMD in osteoporotic mice [36].…”

Section: Discussionmentioning

confidence: 97%

Consumption of vitamin D2 enhanced mushrooms is associated with improved bone health

Chen

Kao

et al. 2015

The Journal of Nutritional Biochemistry

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Mushrooms are the best nonanimal food source of vitamin D2. Pulsed irradiation can enhance vitamin D2 in mushrooms quickly. We investigated the effect of supplementing high vitamin D2Pleurotus ferulae mushrooms in a mouse model of osteoporosis. Thirty-two female C57BL/6JNarl mice were divided into four groups including sham, ovariectomized (OVX), OVX+nonpulsed mushroom (NPM) and OVX+pulsed mushroom (PM). After 23 weeks of treatment, serum samples were analyzed for osteoblast and osteoclast indicators, as well as metabolites using NMR spectroscopy. To examine bone density, femurs were analyzed using micro-computed tomography. The NPM and PM treatment mice showed increased bone density in comparison with OVX mice. In addition, the PM mice showed higher osteoblast and lower osteoclast indicators in comparison with OVX mice. Serum metabolomics analysis indicated several metabolites that were different in PM mice, some of which could be correlated with bone health. Taken together, these results suggest that pulsed irradiated mushrooms are able to increase bone density in osteoporotic mice possibly through enhanced bone metabolism. Further studies in humans are needed to show their efficacy in preventing osteoporosis.

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“…Calcein injections (C-0875; Sigma-Aldrich Chemie, Germany) were given twice, subcutaneously at 20mg/kg, on the 14th and 7th day before sacrifice to allow histological evaluation of bone formation rates [52]. Histological analysis of a long bone cross sections showing distinct rings of stained bone were used to establish the rate of appositional bone growth [53].…”

Section: Activity Monitoringmentioning

confidence: 99%

Mesenchymal stem cell seeded, biomimetic 3D printed scaffolds induce complete bridging of femoral critical sized defects

et al. 2018

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No current clinical treatments provide an ideal long-term solution for repair of long bone segment defects. Incomplete healing prevents patients from returning to preinjury activity and ultimately requires additional surgery to induce healing. Obtaining autologous graft material is costly, incurs morbidity, requires surgical time, and quality material is finite. In this pilot study, 3D printed biomimetic scaffolds were used to facilitate rapid bone bridging in critical sized defects in a sheep model. An inverse trabecular pattern based on micro-CT scans of sheep trabecular bone was printed in polybutylene terephthalate. Scaffolds were coated with micron-sized tricalcium phosphate particles to induce osteoconductivity. Mesenchymal stem cells (MSCs) were isolated from sheep inguinal and tail fat, in one group of sheep and scaffolds were infiltrated with MSCs in a bioreactor. Controls did not undergo surgery for cell extraction. Scaffolds were implanted into two experimental and two control adult sheep, and followed for either 3 or 6 months. Monthly radiographs and post explant micro-CT scanning demonstrated bone formation on the lateral, anterior, medial, and posterior-medial aspects along the entire length of the defect. Bone formation was absent on the posterior-lateral aspect where a muscle is generally attached to the bone. The 3-month time point showed 15.5% more cortical bone deposition around the scaffold circumference while the 6-month time point showed 40.9% more bone deposition within scaffold pores. Control sheep failed to unite. Serum collagen type-1C-terminus telopeptides (CTX-1) showed time-dependent levels of bone resorption, and calcein labeling demonstrated an increase in bone formation rate in treated animals compared with controls. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

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1α-Hydroxyvitamin D2 Is Less Toxic but Not Bone Selective Relative to 1α-Hydroxyvitamin D3 in Ovariectomized Rats

Abstract: ABSTRACT

Cited by 24 publications

References 47 publications

Prevention of Bone Loss in Ovariectomized Rats by Combined Treatment With Risedronate and 1α,25-Dihydroxyvitamin D3

Prevention of Bone Loss in Ovariectomized Rats by Combined Treatment With Risedronate and 1α,25-Dihydroxyvitamin D3

Consumption of vitamin D2 enhanced mushrooms is associated with improved bone health

Mesenchymal stem cell seeded, biomimetic 3D printed scaffolds induce complete bridging of femoral critical sized defects

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