1α, 25-Dihydroxyvitamin D3, and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta

Weisman, Yosef; Harell, A; Edelstein, S.; David, Marion; Spirer, Z; Golander, Avraham

doi:10.1038/281317a0

Cited by 337 publications

(173 citation statements)

References 13 publications

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“…By contrast, serum levels of 1,25(OH) 2 D increase by approximately twofold during the first trimester, and peak during the third trimester (Brannon & Picciano 2011). Renal synthesis of 1,25(OH) 2 D by the mother plays a key role in this elevation of maternal serum 1,25(OH) 2 D levels, but as outlined above, there is also evidence of local 1,25(OH) 2 D generation in both the placenta (fetal) and decidua (maternal) (Gray et al 1979, Weisman et al 1979. Early in pregnancy, the maternal decidua and fetal trophoblast cells show induced expression of both VDR and 1a-hydroxylase (CYP27B1), the enzyme that catalyses conversion of 25OHD to 1,25(OH) 2 D. By contrast, the vitamin D catabolic enzyme, 24-hydroxylase (CYP24A1), shows decreased expression in placental/decidual tissues across gestation (Zehnder et al 2002, Evans et al 2004.…”

Section: Vitamin D and Human Pregnancymentioning

confidence: 93%

“…As 25OHD is the principal marker of vitamin D 'status' in any given individual, this has raised the question as to how vitamin D sufficiency or deficiency may affect tissues in which there is significant metabolism of 25OHD. Prominent among these tissues is the placenta, where both fetal and maternal tissues have been shown to synthesise 'active' 1,25(OH) 2 D (Gray et al 1979, Weisman et al 1979.…”

Section: Vitamin D and Human Pregnancymentioning

confidence: 99%

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Immunological role of vitamin D at the maternal–fetal interface

Tamblyn¹,

Hewison²,

Wagner³

et al. 2015

Journal of Endocrinology

149

104

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Section: Vitamin D and Human Pregnancymentioning

confidence: 93%

Section: Vitamin D and Human Pregnancymentioning

confidence: 99%

Immunological role of vitamin D at the maternal–fetal interface

Tamblyn¹,

Hewison²,

Wagner³

et al. 2015

Journal of Endocrinology

149

104

View full text Add to dashboard Cite

show abstract

“…More than 30 y ago, the placenta was identified as a major site for conversion of 25OHD to the active form of vitamin D, 1,25-dihydroxyvitamin D 3 (1,25[OH] 2 D 3 ), with both maternal decidua and fetal trophoblast demonstrating activity of the enzyme 1a-hydroxylase (CYP27B1) (7,8). However, since then, the precise function of this extrarenal CYP27B1 has remained unclear.…”

mentioning

confidence: 99%

Vitamin D and the Regulation of Placental Inflammation

Liu

Kaplan

Lagishetty

et al. 2011

The Journal of Immunology

182

118

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The vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) and vitamin D receptor (VDR) support anti-inflammatory responses to vitamin D in many tissues. Given the high basal expression of CYP27B1 and VDR in trophoblastic cells from the placenta, we hypothesized that anti-inflammatory effects of vitamin D may be particularly important in this organ. Pregnant wild type (WT) mice i.p. injected with LPS showed elevated expression of mouse Cyp27b1 (4-fold) and VDR (6-fold). Similar results were also obtained after ex vivo treatment of WT placentas with LPS. To assess the functional impact of this, we carried out ex vivo studies using placentas −/− for fetal (trophoblastic) Cyp27b1 or VDR. Vehicle-treated −/− placentas showed increased expression of IFN-γ and decreased expression of IL-10 relative to +/+ placentas. LPS-treated −/− placentas showed increased expression of TLR2, IFN-γ, and IL-6. Array analyses identified other inflammatory factors that are dysregulated in Cyp27b1−/− versus Cyp27b1+/+ placentas after LPS challenge. Data highlighted enhanced expression of IL-4, IL-15, and IL-18, as well as several chemokines and their receptors, in Cyp27b1−/− placentas. Similar results for IL-6 expression were observed with placentas −/− for trophoblastic VDR. Finally, ex vivo treatment of WT placentas with the substrate for Cyp27b1, 25-hydroxyvitamin D3, suppressed LPS-induced expression of IL-6 and the chemokine Ccl11. These data indicate that fetal (trophoblastic) vitamin D plays a pivotal role in controlling placental inflammation. In humans, this may be a key factor in placental responses to infection and associated adverse outcomes of pregnancy.

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“…Historically, the placenta was one of the first of these extra-renal tissues shown to be capable of synthesizing 1,25(OH) 2 D, with CYP27B1 activity being detectable in both maternal decidua and fetal trophoblast. 26,27 Since then we have characterized the spatio-temporal organization of placental CYP27B1 and VDR across gestation, confirming that the enzyme and receptor are localized to both the maternal decidua and fetal trophoblast. Significantly, both proteins are more abundant in 1 st and 2 nd trimester tissue.…”

Section: Vitamin D and Human Pregnancy 69mentioning

confidence: 63%

Vitamin D and Human Pregnancy

Grayson¹,

Hewison

2011

Fet. Matern. Med. Rev.

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At the end of 2007, Time magazine listed the “benefits of vitamin D” as one of its top 10 medical breakthroughs for that year. Since then there has been a remarkable upsurge of interest in vitamin D, with new research advances seemingly published on a weekly basis. In particular, there has been increasing awareness of the variability of vitamin D status in populations across the globe and, significantly, a growing debate about the need for revised parameters for vitamin D supplementation. Although sub-optimal vitamin D is likely to be a widespread problem for 21stcentury societies, it is also clear that some groups are at much greater risk of low vitamin D status. Prominent amongst these are pregnant women and the aim of the following review article will be to discuss this problem in further detail with specific emphasis on its potential physiological and clinical impact.

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1α, 25-Dihydroxyvitamin D3, and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta

Cited by 337 publications

References 13 publications

Immunological role of vitamin D at the maternal–fetal interface

Immunological role of vitamin D at the maternal–fetal interface

Vitamin D and the Regulation of Placental Inflammation

Vitamin D and Human Pregnancy

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