(1S,2S)-Cyclohexane-1,2-diamine-based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria

Abstract

An urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1S,2S)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely Staphylococcus aureus, and Pseudomonas aeruginosa. The obtained results, showing >99.9% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability.

Pure hybrid nanofibers made of 4,4′-bis(triethoxysilyl)-1,1′-biphenyl and the way of their production

“…The spinnable sols used in this study were prepared analogically via the sol-gel process as described elsewhere [38,39]. Bridged organo-bis-silylated precursor (BTEBP), ethanol, deionized water, and HCl were added into a 50 mL round bottom flask and stirred at 700 rpm/30 min/r.t.…”

“…Until 2021, only five solitary research papers regarding the preparation of the purely hybrid organic-inorganic organosilane nanofibers were published. [35][36][37][38][39] Mentioned nanofibers were prepared by three independent groups Tao et al [35], Schramm et al [36,37], and Máková et al [38,39]. The fibrous materials prepared by Tao et al [35] were mainly composed of an inorganic component based on tetraethyl orthosilicate (TEOS).…”

“…Moreover, this surfactant remained inside the prepared hybrid fibers. The third group, Máková et al [38,39], successfully prepared the first types of hybrid organicinorganic nanofibers in a significantly higher molar ratio of hybrid precursors inside the silica dioxide matrix compared to the other two research groups [35][36][37]. They were able to use hybrid precursors based on 1,4-bis(triethoxysilyl)benzene and triethoxyphenylsilane, with the molar ratio reaching up to 40 mol % inside the hybrid matrix [39].…”

“…They were able to use hybrid precursors based on 1,4-bis(triethoxysilyl)benzene and triethoxyphenylsilane, with the molar ratio reaching up to 40 mol % inside the hybrid matrix[39]. Similarly to this, they also prepared hybrid nanofibers made of synthesized organo-bis-silylated precursor ( 1S,2S )-cyclohexane-1,2-diamine with the molar ratio in the organosilica framework up to 43 mol %[38]. Both types of these nanofibers were successfully tested for biomedical purposes[38,39].…”

“…Similarly to this, they also prepared hybrid nanofibers made of synthesized organo-bis-silylated precursor ( 1S,2S )-cyclohexane-1,2-diamine with the molar ratio in the organosilica framework up to 43 mol %[38]. Both types of these nanofibers were successfully tested for biomedical purposes[38,39]. Hybrid organo-bis-silylated precursor 4,4 ′ -bis(triethoxysilyl)-1,1 ′ -biphenyl (BTEBP) is a commercially available precursor.…”