1P052 Competitive binding of metal ions to octarepeat region of prion protein(01C. Protein:Property,Poster)

Abstract

Protein motions occur over a wide range of time scales, but not all are important for protein functions, which time scales are generally longer. Thus, it would be reasonable to consider that slower motions of proteins are more relevant to their functions. To identify such slow protein dynamics from simulation results, we have proposed the time-structure based independent component analysis (tICA). In the present study, we selected lysine-, arginine-, ornithine-binding protein (LAO) as a target protein, and performed one-microsecond molecular dynamics simulation in explicit water. By applying the tICA to the simulation results, several motions in the LAO were identified as slow modes, and were confirmed with additional analyses to be actually occurred. 1P050 トリプリオンタンパク質に対する抗体 G2 の複数の抗原を特 異的に認識する性質の特徴付け Characterization of multispecific monoclonal antibody G2 directed against chicken prion protein