1H NMR spectroscopic identification of a glue sniffing biomarker

Kwon, Bobae; Kim, Siwon; Kim, Sosun; Lee, Dong-Kye; Park, Yu-Jin; Kim, Myung-Duck; Lee, Jae‐Shin; Kim, Suhkmann

doi:10.1016/j.forsciint.2011.01.015

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…ease of quantitation and high reproducibility (Kwon et al 2011) Many of the ∆ 9 -THC activities depend on the interaction with cannabinoid receptors (CB) (Lichtman and Martin 1996). Currently, two CB receptors have been identified, CB 1 and CB 2 .…”

Section: Introductionmentioning

confidence: 99%

Metabolic effects of cannabinoids in zebrafish (Danio rerio) embryos determined by 1H NMR metabolomics

et al. 2016

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Chapter 1General introduction 9Chapter 2 Biotransformation of cannabinoids 21 Chapter 3Hydroxylation and further oxidation of Δ 9 -tetrahydrocannabinol by alkane-degrading bacteria. Chapter 4Hydroxylation and glycosylation of Δ 9 -THC by Catharanthus roseus cell suspension culture analyzed by HPLC-PDA and mass spectrometry Chapter 5Developmental effects of cannabinoids on zebrafish larvae Chapter 6Metabolic effects of cannabinoids in zebrafish (Danio rerio) embryo determined by 1 H NMR metabolomics.

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Section: Introductionmentioning

confidence: 99%

Metabolic effects of cannabinoids in zebrafish (Danio rerio) embryos determined by 1H NMR metabolomics

et al. 2016

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“…Since volatile substances made up the major composition of adhesives, headspace method coupled with gas chromatography technique has been extensively carried out [6,[16][17][18][19][20]. Nuclear magnetic resonance spectroscopy was also reported in detecting chemical compounds in solvent-based adhesives through glue sniffing biomarker [21]. Most literatures mainly reported the effect of volatile compounds from toxicological aspects, while literature on the analysis on solvent-based adhesive is lacking, though it can become important physical evidence in related forensic cases.…”

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confidence: 99%

Profiling of cured residue of solvent‐based adhesives by attenuated total reflectance–Fourier transform infrared spectroscopy with chemometrics for forensic investigation

Saman

Chang

Abdullah

2020

Journal of Forensic Sciences

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Abuse of solvent‐based adhesives jeopardizes world population, especially the young generation. Adhesive‐related exhibits encountered in forensic cases might need to be determined if they could have come from a particular source or to establish link between cases or persons. This study was aimed to discriminate solvent‐based adhesives, especially to aid forensic investigation of glue sniffing activities. In this study, thirteen brands with three samples each, totaling at 39 adhesive samples, were analyzed using attenuated total reflectance–Fourier transform infrared (ATR‐FTIR) spectroscopy followed by chemometric methods. Experimental output showed that adhesive samples utilized in this study were less likely to change in their ATR‐FTIR profiles over time, at least up to 2 months. No interference from plastic materials was noticed based on ATR‐FTIR profile comparison. Physical examination could differentiate the samples into two groups, namely contact adhesives and cement adhesives. A principal component analysis‐score linear discriminative analysis (PC‐score LDA) model resulted in 100% and 98.6% correct classification in discriminating the two groups of adhesive samples, forming seven discriminative clusters. Test set with adhesive samples applied glass slide and plastic substrates also demonstrated a 100% correct classification into their respective groups. As a conclusion, the method allowed for discrimination of adhesive samples based on the spectral features, displaying relationship among samples. It is hoped that this comparative information is beneficial to trace the possible source of solvent‐based adhesives, whenever they are recovered from a crime scene, for forensic investigation.

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“…Dr. Kim will confirm the metabolic pathways causing those differences in future work. For the forensic applications, he analyzed urine from an individual with a history of sniffing glue using NMRbased metabolomics (Kwon et al 2011). Toluene is the main solvent ingredient of glue, but it is not soluble in water and is difficult to detect in biofluid.…”

mentioning

confidence: 99%