1H NMR-based metabolomics approach to investigate the urine samples of collagen-induced arthritis rats and the intervention of tetrandrine

Yun, Xinming; Dong, Shu; Hu, Qiaoqiao; Dai, Yue; Xia, Yufeng

doi:10.1016/j.jpba.2018.03.026

Cited by 18 publications

(14 citation statements)

References 31 publications

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“…There are also 23 potential metabolites of the drug, including glycine, creatine, creatinine, taurine, trimethylamine N‐oxide, xanthurenate and phenylacetylglycine,, that have been detected in the urine of collagen‐induced arthritis (CIA) rats, and these participate primarily in energy metabolism, lipid metabolism, amino acid metabolism and intestinal flora metabolism, using the metabolomics approach, like glycine, taurine and trimethylamine N‐oxide. [ 158 ] These potential biomarkers and metabolic pathways might provide new ways of looking at the potential therapeutic targets of tetrandrine against RA. Li et al (2016) identified 26 metabolites of tetrandrine in the rat's blood, urine and incubation samples using UHPLC combined with QTOF, and they proposed the metabolic pathways of tetrandrine, with the main MS 2 parent fragments consisting of 174.09, 381.18, 560.25, 592.27 and 623.31.…”

Section: Pharmacokinetic Studies Of Tetrandrinementioning

confidence: 99%

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

Luan

Zeng

2020

Journal of Pharmacy and Pharmacology

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Objectives Tetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising anticancer activities on diverse tumours. This review provides systematically organized information on cancers of tetrandrine in vivo and in vitro, discuss the related molecular mechanisms and put forward some new insights for the future investigations. Key findings Anticancer activities of tetrandrine have been reported comprehensively, including lung cancer, colon cancer, bladder cancer, prostate cancer, ovarian cancer, gastric cancer, breast cancer, pancreatic cancer, cervical cancer and liver cancer. The potential molecular mechanisms corresponding to the anticancer activities of tetrandrine might be related to induce cancer cell apoptosis, autophagy and cell cycle arrest, inhibit cell proliferation, migration and invasion, ameliorate metastasis and suppress tumour cell growth. Pharmaceutical applications of tetrandrine combined with nanoparticle delivery system including liposomes, microspheres and nanoparticles with better therapeutic efficiency have been designed and applied encapsulate tetrandrine to enhance its stability and efficacy in cancer treatment. Summary Tetrandrine was proven to have definite antitumour activities. However, the safety, bioavailability and pharmacokinetic parameter studies on tetrandrine are very limited in animal models, especially in clinical settings. Our present review on anticancer potentials of tetrandrine would be necessary and highly beneficial for providing guidelines and directions for further research of tetrandrine.

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Section: Pharmacokinetic Studies Of Tetrandrinementioning

confidence: 99%

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

Luan

Zeng

2020

Journal of Pharmacy and Pharmacology

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“…Although the subjects with RA mainly manifests a pathological change in synovial joint and cartilage, recent studies reported that the autoimmune response in patients with RA was initiated outside the joint, affected different parts of the body, and resulted in multi-organ disorders inevitably [ 48 ]. The inflammation related pathways and cytokines that we detected in the joint ankle tissue could reflect the pathophysiological changes more sufficiently.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Methotrexate on Rheumatoid Arthritis Inflammation and Comprehensive Metabolomics Analysis Using Ultra-Performance Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (UPLC-Q/TOF-MS)

Pang

Wang

Ran

et al. 2018

IJMS

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Rheumatoid arthritis (RA) is a common autoimmune disease. The inflammation in joint tissue and system endanger the human health seriously. Methotrexate have exhibited a satisfactory therapeutic effect in clinical practice. The aim of this research was to establish the pharmacological mechanism of methotrexate on RA therapy. Collagen induced arthritic rats were used to identify how methotrexate alleviates inflammation in vivo. Lipopolysaccharide-induced inflammatory proliferation in macrophages was also be detected in vitro. The activation level of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Nucleotide binding domain and leucine-rich repeat pyrin 3 domain (NLRP3)/Caspase-1 and related cytokines were examined by real-time PCR and western blotting or quantified with the enzyme-linked immunosorbent assay. Comprehensive metabolomics analysis was performed to identify the alteration of metabolites. Results showed that treating with methotrexate could alleviate the inflammatory condition, downregulate the activation of NF-κB and NLRP3/Caspase-1 inflammatory pathways and reduce the level of related cytokines. Docking interaction between methotrexate and caspase-1 was visualized as six H-bonds indicating a potential inhibitory effect. Metabolomics analysis reported three perturbed metabolic inflammation related pathways including arachidonic acid, linoleic acid and sphingolipid metabolism. These findings indicated that methotrexate could inhibit the onset of inflammation in joint tissue by suppressing the activation of NF-κB and NLRP3/Caspase-1 pathways and regulating the inflammation related metabolic networks.

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“…Only two compounds, 9 and 52, have been evaluated for their antibacterial effects. Tetrandrine (9) (200.9, 401.9 or 803.8 lM) exhibited a synergistic effect against methicillin-resistant Staphylococcus aureus (MRSA) when combined with the multi-drug resistant (MDR)-efflux pump substrate ethidium bromide, causing a two to fourfold reduction in the minimum inhibitory concentration (MIC) of ethidium bromide against MRSA using a combined test (Lee et al 2011 Lai (2002), Sekiya et al (2004), Seow et al (1988), Lai et al (1999), Yun et al (2018), Yuan et al (2016), Lv et al (2015), Shan et al (2018), Hu et al (2012), Zhang et al (2018a, b, c, d), Zhang (2014), Sun et al (2016) Antifibrotic effects Antifibrotic effects in pulmonary disease . Though the compound exhibited potent inhibitory activity against S. aureus, the required dose of the two compounds was excessive in these studies, the experimental data not being relevant to clinical applications.…”

Section: Antibacterial Effectsmentioning

confidence: 99%

“…CD28-costimulation (Lai et al 1999). They have also been shown to reverse the pathological process of collagen-induced arthritis by modulating metabolic pathway imbalances (Yun et al 2018), markedly alleviating the severity of arthritis and reducing serum concentrations of pro-inflammatory cytokines. The compounds further restored the ratio of T helper 17 (Th17)/ regulatory T (Treg) cells.…”

Section: Immunomodulatory Effectsmentioning

confidence: 99%

A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

2020

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Stephania tetrandra S. Moore (S. tetrandra) is distributed widely in tropical and subtropical regions of Asia and Africa. The root of this plant is known in Chinese as ''Fen Fang Ji''. It is commonly used in traditional Chinese medicine to treat arthralgia caused by rheumatism, wet beriberi, dysuria, eczema and inflamed sores. Although promising reports have been published on the various chemical constituents and activities of S. tetrandra, no review comprehensively summarizes its traditional uses, phytochemistry, pharmacology and toxicology. Therefore, the review aims to provide a critical and comprehensive evaluation of the traditional use, phytochemistry, pharmacological properties, pharmacokinetics and toxicology of S. tetrandra in China, and meaningful guidelines for future investigations.

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1H NMR-based metabolomics approach to investigate the urine samples of collagen-induced arthritis rats and the intervention of tetrandrine

Cited by 18 publications

References 31 publications

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

Inhibitory Effect of Methotrexate on Rheumatoid Arthritis Inflammation and Comprehensive Metabolomics Analysis Using Ultra-Performance Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (UPLC-Q/TOF-MS)

A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

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