1H MRSI of middle frontal gyrus in pediatric ADHD

Tafazoli, Sharwin; O’Neill, Joseph; Bejjani, Anthony; Ly, Ronald; Salamon, Noriko; McCracken, James T.; Alger, Jeffry R.; Levitt, Jennifer G.

doi:10.1016/j.jpsychires.2012.11.011

Cited by 46 publications

(34 citation statements)

References 69 publications

(97 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest that, in ADHD, a different metabolic pattern is followed, with respect to controls, during ontogeny and progression of age. In 2013, Tafazoli et al 34 investigated the bilateral middle frontal gyrus (or dorsolateral prefrontal cortex) in subjects with ADHD (8 boys, 5 girls; mean age, 12.3 years) compared with healthy subjects (8 boys, 5 girls; mean age, 12.2 years) by short-TE chemical shift imaging by using a quantitative protocol. In addition to short TE and water as internal references, the authors used a self-made software to correct for CSF.…”

Section: Clinical Mr Spectroscopy Findings: Patients With Adhdmentioning

confidence: 99%

See 1 more Smart Citation

MR Imaging-Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies

Altabella

Zoratto

Adriani

et al. 2014

American Journal of Neuroradiology

View full text Add to dashboard Cite

MR spectroscopy represents one of the most suitable in vivo tool to assess neurochemical dysfunction in several brain disorders, including attention deficit/hyperactivity disorder. This is the most common neuropsychiatric disorder in childhood and adolescence, which persists into adulthood (in approximately 30%-50% of cases). In past years, many studies have applied different MR spectroscopy techniques to investigate the pathogenesis and effect of conventional treatments. In this article, we review the most recent clinical and preclinical MR spectroscopy results on subjects with attention deficit/hyperactivity disorder and animal models, from childhood to adulthood. We found that the most investigated brain regions were the (pre)frontal lobes and striatum, both involved in the frontostriatal circuits and networks that are known to be impaired in this pathology. Neurometabolite alterations were detected in several regions: the NAA, choline, and glutamatergic compounds. The creatine pool was also altered when an absolute quantitative protocol was adopted. In particular, glutamate was increased in children with attention deficit/hyperactivity disorder, and this can apparently be reversed by methylphenidate treatment. The main difficulties in reviewing MR spectroscopy studies were in the nonhomogeneity of the analyzed subjects, the variety of the investigated brain regions, and also the use of different MR spectroscopy techniques. As for possible improvements in future studies, we recommend the use of standardized protocols and the analysis of other brain regions of particular interest for attention deficit hyperactivity disorder, like the hippocampus, limbic structures, thalamus, and cerebellum.ABBREVIATIONS: ACC ϭ anterior cingulate cortex; ADHD ϭ attention deficit/hyperactivity disorder; Cho ϭ total choline (phosphorylcholine ϩ glycerolphosphorylcholine); GABA ϭ ␥-aminobutyric acid; PFC ϭ prefrontal cortex; PRESS ϭ point-resolved spectroscopy sequence; tCr ϭ total creatine (creatine ϩ phosphorylcreatine) A ttention deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disease in children and adolescents. Marked differences in the ADHD prevalence are thought to exist among countries. In fact, the estimated prevalence is 4%-7% in the United States and 1%-3% in Europe.1 ADHD, which is 2-4 times more frequent in males than in females, is characterized by traits of inattention, impulsivity, and motor hyperactivity. These can significantly impact many aspects of behavior in children and adolescents and can affect their performance, both at school and at home. The symptoms of ADHD have a negative impact on the individual throughout childhood, adolescence, and well into adult life, especially if not managed optimally. In approximately 80% of children with ADHD, symptoms persist into adolescence and may persist into adulthood in approximately 30%-50% of cases. ADHD adolescents and adults retain from infancy the traits of inattention and impulsivity. Moreover, they start to show a propensity for ...

show abstract

Section: Clinical Mr Spectroscopy Findings: Patients With Adhdmentioning

confidence: 99%

“…The decrease of NAA in the dorsolateral PFC and cerebellum of pediatric subjects 34,35 and in the dorsolateral PFC of adults 40 does not necessarily mean a neuronal cell loss, but it can also be interpreted as a neuronal dysfunction. 61 This metabolic reduction is reversed in adults by methylphenidate administration.…”

mentioning

confidence: 98%

MR Imaging-Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies

Altabella

Zoratto

Adriani

et al. 2014

American Journal of Neuroradiology

View full text Add to dashboard Cite

show abstract

“…In a review of sixteen 1 H MRS studies of ADHD children, the levels of Cho (increased), NAA (decreased), and GluþGln (increased) were reported to be altered, compared to healthy control groups (Perlov et al, 2009). Decreased levels of NAA within frontal lobe have also been reported in more recent ADHD studies (Arcos-Burgos et al, 2012;Tafazoli et al, 2013) (Table 1).…”

Section: Introductionmentioning

confidence: 95%

“…The most frequently assessed region in 1 H magnetic resonance spectroscopy (MRS) studies of ADHD is the prefrontal cortex (Perlov et al, 2009) and the most frequently measured metabolites assessed with 1 H MRS were N-acetyl-aspartate (NAA), glutamate þglutamine (Glu þGln), creatineþphosphocreatine (Cr), and choline compounds (Cho) (Tafazoli et al, 2013). In a review of sixteen 1 H MRS studies of ADHD children, the levels of Cho (increased), NAA (decreased), and GluþGln (increased) were reported to be altered, compared to healthy control groups (Perlov et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Neurochemical correlates of internet game play in adolescents with attention deficit hyperactivity disorder: A proton magnetic resonance spectroscopy (MRS) study

Bae

Han

Kim

et al. 2016

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

“…Considering the extensive neurometabolic role that mI plays, it is not surprising that altered concentrations have been previously detected in a variety of neurological, psychiatric, and behavioural conditions, including head injuries, Alzheimer disease, attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder, and sleep and mood disorders in different age groups [48,49,50,51,52,53,54,55]. It has been suggested that a reduced cerebral mI concentration is a neurochemical biomarker for depression; lower inositol has been reported in the cerebrospinal fluid of depressed patients [56] as well as in the frontal cortex of suicide victims (postmortem) and patients with bipolar disorder [57].…”

Section: Discussionmentioning

confidence: 99%

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study

Urrila¹,

Hakkarainen

Castaneda

et al. 2017

Neuropsychobiology

View full text Add to dashboard Cite

Aim: This study used proton magnetic resonance spectroscopy (¹H MRS) to evaluate the neurochemistry of the frontal cortex in adolescents with symptoms of sleep and depression. Methods: Nineteen non-medicated adolescent boys (mean age 16.0 years; 9 clinical cases with depression/sleep symptoms and 10 healthy controls) underwent ¹H MRS at 3 T. MR spectra were acquired from the anterior cingulate cortex (ACC), the dorsolateral prefrontal cortex, and frontal white matter. Concentrations of N-acetyl aspartate, total creatine, choline-containing compounds, total glutamine plus glutamate, and myo-inositol (mI) were compared in the 2 subgroups, and correlated with sleep and clinical measures in the total sample. Sleep was assessed with self-report questionnaires and ambulatory polysomnography recordings. Results: Concentrations of mI were lower in both frontal cortical regions among the depressed adolescents than in controls. No statistically significant differences in other metabolite concentrations were observed between the subgroups. Frontal cortex mI concentrations correlated negatively with depression severity, subjective daytime sleepiness, insomnia symptoms, and the level of anxiety, and correlated positively with total sleep time and overall psychosocial functioning. The correlations between mI in the ACC and total sleep time as well as daytime sleepiness remained statistically significant when depression severity was controlled in the analyses. Conclusion: Lower frontal cortex mI may indicate a disturbed second messenger system. Frontal cortical mI may thus be linked to the pathophysiology of depression and concomitant sleep symptoms among maturing adolescents. Short sleep and daytime sleepiness may be associated with frontal cortex mI independently from depression.

show abstract

1H MRSI of middle frontal gyrus in pediatric ADHD

Cited by 46 publications

References 69 publications

MR Imaging-Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies

MR Imaging-Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies

Neurochemical correlates of internet game play in adolescents with attention deficit hyperactivity disorder: A proton magnetic resonance spectroscopy (MRS) study

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study

Contact Info

Product

Resources

About