1H-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas

Tarnawski, Rafał; Sokół, Maria; Pienia̦żek, Piotr; Maciejewski, B.; Walecki, Jerzy; Miszczyk, Leszek; Krupska, Teresa

doi:10.1016/s0360-3016(01)02769-9

Cited by 85 publications

(55 citation statements)

References 13 publications

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Section: Discussionmentioning

confidence: 95%

“…The Lac concentration is a better indicator of survival than are tumor grade and patient age (24). To the best of our knowledge, there have been no previous reports on the relationship between Lac concentration and prognosis in brain tumors and cervical cancer (8,24,25). The current findings are in accordance with those of Walenta et al (7,8), who found that a higher Lac concentration indicated poorer survival probabilities in human cervical cancers and a higher incidence of metastasis in head and neck tumors (9).…”

Section: Discussionmentioning

confidence: 95%

“…A high Lac concentration in cases of cervical cancer and brain tumor has been shown to be of value in the prognostic evaluation of some tumors (7,8,17,24). The Lac concentration is a better indicator of survival than are tumor grade and patient age (24).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study the survival analysis showed that survival was generally longer for patients with a lower Lac concentration, and the difference was statistically significant in both the diseasefree and the overall survival analyses (mean Ϯ SD, 50.28 Ϯ 6.47, P ϭ 0.039). Tarnawski et al (24) found that the Lac/NAA ratio was the strongest independent prognostic and predictive factor for patient survival in malignant glioma. For Lac/ NAA ratios Ͼ 2.0, the one-year survival rate was 20%, and for Lac/NAA ratios Ͻ 2.0, the one-year survival rate was 85%.…”

Section: In Vitro 1 H-mrs Of Excised Lung Cancermentioning

confidence: 99%

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Lactate, choline, and creatine levels measured by vitro ¹H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer

Yokota

Guo

Matoba

et al. 2007

Magnetic Resonance Imaging

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PurposeTo determine the biochemical characteristics of lung cancer tissue using in vitro 1H‐MRS, and investigate the correlation between survival probabilities and lactate (Lac), creatine (Cr), and choline (Cho) concentrations measured by in vitro 1H‐MRS.Materials and MethodsA total of 21 patients with lung cancer were included in this retrospective study. 1H‐MRS spectra measurements were performed at 6.35T using a JNM‐EX270, high‐resolution FT‐NMR spectrometer.ResultsWhen normal lung tissue was compared with lung cancer tissue, significant differences were noted most consistently in the levels of Lac and Cho, with lung cancer tissue showing higher values than normal lung tissue. Lac concentrations of lung cancer tissue were significantly higher in patients with recurrence compared to patients without recurrence (0.285 ± 0.096 μmol/g). The mean overall survival of patients in the low‐Lac group was 50.28 ± 6.47 months, which is significantly higher compared to the high‐Lac group, which had a mean survival time of only 30.49 ± 5.41 months.ConclusionKaplan‐Meier analysis of the data showed that the overall and disease‐free survival probabilities were significantly higher in patients with low tumor Lac values than in those with high tumor Lac concentrations. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: In Vitro 1 H-mrs Of Excised Lung Cancermentioning

confidence: 99%

See 2 more Smart Citations

Lactate, choline, and creatine levels measured by vitro ¹H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer

Yokota

Guo

Matoba

et al. 2007

Magnetic Resonance Imaging

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“…Subsequent work has shown that fDM when combined with conventional radiological response can provide a more accurate prediction of patient survival than either measure alone [21]. 1 H-MRS has also been shown to be a useful predictor of early treatment outcome following radiotherapy: the lactate/NAA ratio was a stronger prognostic factor for survival in malignant gliomas even more than patient age and tumour grade [22].…”

Section: Early Assessment Of Treatment Responsementioning

confidence: 99%

Diagnosis and treatment in neuro-oncology: an oncological perspective

Rees

2011

BJR

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ABSTRACT. Although brain tumours are rare compared with other malignancies, they are responsible, in many cases, for severe physical and cognitive disability and have a high case fatality rate (13% overall survival at 5 years). Gliomas account for over 60% of primary brain tumours and usually present with one or more symptoms of raised intracranial pressure, progressive neurological deficit, seizures, focal or global cognitive decline. The diagnosis is made by a combination of imaging and histological examination of tumour specimen. Contrast-enhanced MRI is the gold standard imaging modality and provides highly sensitive anatomical information about the tumour. Advanced imaging modalities provide complementary information about brain tumour metabolism, blood flow and ultrastructure and are being increasingly incorporated into routine clinical sequences. Imaging is essential for guiding surgery and radiotherapy treatments and for monitoring response to, and progression of, therapy. However, changes in imaging over time may be misinterpreted and lead to incorrect assumptions about the effectiveness of treatments. Thus, the disappearance of contrast enhancement and resolution of oedema after anti-angiogenesis treatments is seen early while conventional T 2 weighted/FLAIR sequences demonstrate continual tumour growth (pseudoregression). Conversely imaging may suggest lack of efficacy of treatment e.g. increasing tumour size and contrast enhancement following chemoradiation for malignant gliomas (pseudoprogression), which then stabilise or resolve after a few months of continued treatment and that paradoxically may be associated with a better outcome. These factors have led to a re-evaluation of the role of standard sequences in the assessment of treatment response spurning interest in the development of quantitative biomarkers.

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Brain Tumor MRS

Howe

Peet

1996

eMagRes

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1H-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas

Cited by 85 publications

References 13 publications

Lactate, choline, and creatine levels measured by vitro ¹H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer

Lactate, choline, and creatine levels measured by vitro ¹H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer

Diagnosis and treatment in neuro-oncology: an oncological perspective

Brain Tumor MRS

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1H-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas

Cited by 85 publications

References 13 publications

Lactate, choline, and creatine levels measured by vitro 1H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer

Lactate, choline, and creatine levels measured by vitro 1H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer

Diagnosis and treatment in neuro-oncology: an oncological perspective

Brain Tumor MRS

Contact Info

Product

Resources

About

Lactate, choline, and creatine levels measured by vitro ¹H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer

Lactate, choline, and creatine levels measured by vitro ¹H‐MRS as prognostic parameters in patients with non‐small‐cell lung cancer