1H HR-MAS NMR spectroscopy as a simple tool to characterize peptide – Functionalized hydrogels as a function of cross linker density

The Synergistic Effect of Cationic Moieties and GRGDSF‐Peptides in Hydrogels on Neural Stem Cell Behavior

“…1 H HR MAS NMR spectroscopy of the hydrogels P1 , P2 , and P3 was used to analyze the hydrogels in the swollen state. As has been demonstrated recently this method can be successfully applied to elucidate the composition of bioactive, chemically cross linked hydrogels and quantify the peptide content . Figure shows the 1 H HR MAS spectrum of P1–P3 swollen in a D 2 O/H 2 O mixture.…”

Synthesis of redox-responsive core–shell nanoparticles: insights into core-crosslinking efficiency

“…In addition, this NMR method appears not to be suitable for strongly crosslinked polymer networks as the analysis of hydrogels with different crosslinking densities recently showed. 25 Therefore, the solution to the problem, especially for medical applications, is that nanoparticles crosslinked by core or shell are purified by dialysis for several days after synthesis. To separate the nanoparticle from non-reacted precursor polymer before they are employed for further in vitro and in vivo experiments.…”

Protected thiol strategies in macromolecular design

“…Moreover, the gels swelled in acidic environment, which also offers potential for releasing compounds in acidic (inflamed) tissue. Besides hydrogels and nanogels [79][80][81][82], redox-responsive disulfide containing polymers were for example also used for the synthesis of hollow microspheres [83], star polymers [84][85][86] and micelles [87,88].…”