(1H-Benzo[d][1,2,3]triazol-1-yl)(5-bromo-1-hydroxy-1H-indol-3-yl)methanone

Abstract

The title compound was easily prepared by a nitrosoarene-alkyne cycloaddition reaction carried out in toluene at 80 °C. The product is a highly functionalized compound that can be further derivatized through various functional group interconversion procedures

Further Developments on the Regioselective Synthesis of 3-Aroylindole Derivatives from <i>C</i>-Nitrosoaromatics and Alkynones: A Novel Synthetic Approach to Pravadoline, JWH-073, Indothiazinone Analogues and Related Compounds

“…However, when investigating ethynylpyrimidines for the synthesis of meridianins and related compounds [57], which are known as kinase inhibitors [58], an equimolar ratio between the nitrosoarene and the alkyne could be used. In our more recent work describing the synthesis of 3-aroylindoles with conjugated alkynones and nitrosoarenes, the optimal 1:1 stoichiometric ratio between the two coupling partners was also achieved [59] [60] [61]. Thus, the use of conjugated alkynones instead of simple aromatic alkynes has dramatically improved our indolization strategy.…”

Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles

“…Gels 2021, 7, x FOR PEER REVIEW 3 of 14 compounds [57][58][59][60], we prepared a set of bi-and trifunctional tetrazoles and applied them for the first time in the photoinduced cross-linking of porcine skin gelatin.…”

“…However, it may be ideal as an effective cross-linking strategy to achieve improvements in the macroscopic characteristics of biological materials, such as gelatin. Intrigued by this possibility and exploiting our expertise in the synthesis of heterocyclic compounds [57][58][59][60], we prepared a set of bi-and trifunctional tetrazoles and applied them for the first time in the photoinduced cross-linking of porcine skin gelatin.…”