1H- and 17O-NMR studies of distilled spirit: New methods for assessing the aging process of Awamori.

武, 玉城; 和弘, 松下; 克哉, 樋岡; 義治, 高宮

doi:10.1271/nogeikagaku1924.60.191

Cited by 5 publications

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“…A similar phenomenon is observed in solid, chemically homogeneous drugs, the pharmacological effects of which differ due to the differing absorption and/or distribution caused by their different physical properties (bioavailability). l 4 Our findings on the relationship between biological reactivity and the structure of an ethanol solution suggest that the development of alcoholism may be modulated by selecting types of liquor, because the solution structures change during the aging proces~es.~ Furthermore, it is widely believed that the dynamic structure of solutions modulates the relationships between substances and their biological reactivity, such as their pharmacokinetics, pharmacological effects, and toxicity.…”

Section: Discussionmentioning

confidence: 85%

Diminution of Biological Reactivity of Ethanol by Changing the Solution Structure by Weak Ultrasonication

Haseba

Matsushita

Asakura

et al. 1993

Alcoholism Clin & Exp Res

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The weak ultrasonication (40 kHz, 12 mW, 1 week) of ethanol solutions was found to reduce stimulation of the senses of smell and taste by the ethanol on the basis of blind tests with an aqueous ethanol solution (33.0% w/v) and an immature distilled spirit (25.0% v/v). Experiments on mice also demonstrated that a treated aqueous ethanol solution had a weaker depressant effect on the central nervous system, as evaluated by the relative frequency with which mice regained the righting reflex at a dose of either 4.0 or 4.5 g/kg (p < 0.05 or p < 0.01, respectively) and by the reduction in rectal temperature at a dose of 5.0 g/kg (p < 0.05) soon after ethanol administration. Analyses of both the ethanol concentration by head-space gas chromatography and the free radicals by electron spin resonance spectrometer failed to reveal any chemical changes in aqueous ethanol solutions subjected to weak ultrasonication. However, measurement of the spin-lattice relaxation time (T1) of the 2H of water molecules by 2H-NMR showed that the treatment slightly accelerated the thermal motion of water molecules in the solutions. Treated solutions were also found to have a slightly higher density than untreated ones. These physical data demonstrate that weak ultrasonication induces a structural change, such as a more compact and homogeneous structure by changing the microdynamic behavior of the solution. These biological and physical studies suggest that only a slight structural change in an ethanol solution induces a marked change in the biological reactivity of ethanol without any chemical modification of the solution itself.

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Section: Discussionmentioning

confidence: 85%

Diminution of Biological Reactivity of Ethanol by Changing the Solution Structure by Weak Ultrasonication

Haseba

Matsushita

Asakura

et al. 1993

Alcoholism Clin & Exp Res

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“…Several studies have been reported upon the water−ethanol structure change in distilled spirits with different analytical methods. Akahoshi and Ohkuma () have examined the chemical shifts and half-bandwidths of 1 H NMR spectra, and others ( − ) have analyzed the half-bandwidths of 1 H or 17 O NMR spectra. Furusawa et al.…”

Section: Introductionmentioning

confidence: 99%

Solute Effects on the Interaction between Water and Ethanol in Aged Whiskey

Nose

Hojo

Suzuki

et al. 2004

J. Agric. Food Chem.

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The hydrogen-bonding structure of water-ethanol in whiskey was examined on the basis of (1)H NMR chemical shifts of the OH of water and ethanol. Phenolic acids and aldehydes (gallic, vanillic, and syringic acids; vanillin and syringaldehyde) exhibited their structure-making effects regardless of the presence or absence of 0.1 or 0.2 mol dm(-3) acetic acid. The OH-proton chemical shifts were measured for 32 malt whiskey samples of a distillery, aged for 0-23 years in five different types of casks. The OH-proton chemical shift values of the whiskies shifted toward the lower field in proportion to their contents of total phenols. It can be concluded that the strength of the hydrogen bonding in aged whiskies is directly predominated by acidic and phenolic components gained in oak wood casks and not dependent on just the aging time.

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ESR and NMR spectroscopy

Iley

Taylor

1993

PATAI'S Chemistry of Functional Groups

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1H- and 17O-NMR studies of distilled spirit: New methods for assessing the aging process of Awamori.

Cited by 5 publications

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Diminution of Biological Reactivity of Ethanol by Changing the Solution Structure by Weak Ultrasonication

Diminution of Biological Reactivity of Ethanol by Changing the Solution Structure by Weak Ultrasonication

Solute Effects on the Interaction between Water and Ethanol in Aged Whiskey

ESR and NMR spectroscopy

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