Abstract:Most of the translational control of gene expression in higher eukaryotes occurs during the initiation step of protein synthesis. While this process is well characterized in mammalian cells, it is less defined in parasites, including the ones that cause human Leishmaniasis. The Leishmania cap-binding isoform 1 (LeishIF4E-1) is the only isoform that binds the specific trypanosomatids-specific hypermethylated 5′ cap, called cap-4, in the human stage of the parasite life cycle. We report here the extensive NMR re… Show more
“…In addition, a structural alignment between LmIF4E-1 and TcIF4E5 was performed in that work, thus enabling the description of the structural similarities and differences between these two initiation factors [33] . Finally, an NMR assignment of the backbone of LmIF4E-1 bound to m 7 GTP was obtained, which provided additional information about cap-binding mode in this initiation factor [34] . …”
“…In addition, a structural alignment between LmIF4E-1 and TcIF4E5 was performed in that work, thus enabling the description of the structural similarities and differences between these two initiation factors [33] . Finally, an NMR assignment of the backbone of LmIF4E-1 bound to m 7 GTP was obtained, which provided additional information about cap-binding mode in this initiation factor [34] . …”
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