1D coordination polymer based on copper(II)-containing tetrameric 1,2,3-triazole ligand from click chemistry: Magnetic and catalytic properties

Moraes, Leonardo C.; Souza, G.P. de; Fajardo, Humberto V.; Luz, Sulusmon C.; Álvarez, Eleuterio; Lloret, Francesc; Ribeiro-Viana, Renato; Rojo, Javier; Stumpf, Humberto O.; Figueiredo, Rute Cunha; Corrêa, Rodrigo S.

doi:10.1016/j.ica.2019.02.010

Cited by 9 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For comparison, scaffolds 4 and 5 with a pentaerythritol core and presenting 4 and 6 alkyne functions, respectively, were prepared following reported procedures (Scheme 1). [40,41] Indeed, the tetravalent scaffold 4 has already been used to generate multivalent inhibitors of various glycosidases. [37,39,[42][43][44] Noteworthy, Compain et al have also used this scaffold to prepare the β-GCase PC 3, as mentioned above.…”

Section: Preparation Of Pentaerythritol-based Multivalent Iminosugars...mentioning

confidence: 99%

Phosphorus Dendrimers for Metal‐Free Ligation: Design of Multivalent Pharmacological Chaperones against Gaucher Disease

Tran

Borie-Guichot

Garcia

et al. 2023

Chemistry A European J

View full text Add to dashboard Cite

The first phosphorus dendrimers built on a cyclotriphosphazene core and decorated with six or twelve monofluorocyclooctyne units were prepared. A simple stirring allowed the grafting of N‐hexyl deoxynojirimycin inhitopes onto their surface by copper–free strain promoted alkyne‐azide cycloaddition click reaction. The synthesized iminosugars clusters were tested as multivalent inhibitors of the biologically relevant enzymes β‐glucocerebrosidase and acid α‐glucosidase, involved in Gaucher and Pompe lysosomal storage diseases, respectively. For both enzymes, all the multivalent compounds were more potent than the reference N‐hexyl deoxynojirimycin. Remarkably, final dodecavalent compound proved to be one of the best β‐glucocerebrosidase inhibitors described to date. These cyclotriphosphazene‐based deoxynojirimycin dendrimers were then evaluated as pharmacological chaperones against Gaucher disease. Not only did these multivalent constructs cross the cell membranes but they were also able to increase β‐glucocerebrosidase activity in Gaucher cells. Notably, dodecavalent compound allowed a 1.4‐fold enzyme activity enhancement at a concentration as low as 100 nM. These new monofluorocyclooctyne‐presenting dendrimers may further find numerous applications in the synthesis of multivalent objects for biological and pharmacological purposes.

show abstract

Section: Preparation Of Pentaerythritol-based Multivalent Iminosugars...mentioning

confidence: 99%

Phosphorus Dendrimers for Metal‐Free Ligation: Design of Multivalent Pharmacological Chaperones against Gaucher Disease

Tran

Borie-Guichot

Garcia

et al. 2023

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…Anions like thiocyanate (SCN ) and azide (N 3 ) acting as bridging ligands play a prominent role in determining the structure of polymeric metal-organic compounds, particularly when the chelating ligand is neutral. The thiocyanate anion is coordinated either through nitrogen (N) or sulfur (S) atom or both, giving rise to linkage isomers, dimers, or polymers [14].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the X-ray crystallography temperature, synthesis method, optical properties, NCI-RDG and Hirshfeld surface analyses of coordination polymer of [CuI(DAFO)(SCN)]n: an amenable precursor for CuO nanoparticles

et al. 2023

View full text Add to dashboard Cite

1D Coordination Polymer (CP) of [Cu I (1,3-NCS)(DAFO)]n (CP1) (DAFO = 4,5-Diaza uoren-9-one) was synthesized using a branched tube method in ethanol and compared with previously synthesized CP2. Although the synthesis methods and parameters for CPs were di erent, both of them were formed in a similar crystal system (orthorhombic) and space group (P mn2 1 ) based on their X-ray crystallography data. Optical properties and structure of CP1 were further investigated in detail. Variation of the crystallography temperature causes slight di erences in the bond lengths and angles of the geometry center. Hirshfeld surface analyses show the signi cant contribution of H{C...H (18.9%) for CP1 and H{C...H (19.9%) for CP2. The most obvious distinctions between the CP interactions were C{N (8.4%) and (3.3%), Cu{S (4.8%) and (0.0%), and Cu{N (3.3%) and (11.4%) for CP1 and CP2, respectively. Non-Covalent Interaction-Reduced Density Gradient (NCI-RDG) analysis was conducted to broaden our understanding of the structure-directing interactions in these complexes. CP1 experienced signi cant inter-and intramolecular interactions according to Hirshfeld surface and NCI-RDG analyses. Solventfree decomposition of CP1 crystals at 750 C led to the synthesis of copper oxide (CuO) nanoparticles with a particle size of 12 nm.

show abstract

Structure and magnetic properties of a serendipitously synthesized copper(II) complex: [Cu(3-Br-2-pyone)6](ClO4)2

et al. 2020

View full text Add to dashboard Cite

1D coordination polymer based on copper(II)-containing tetrameric 1,2,3-triazole ligand from click chemistry: Magnetic and catalytic properties

Cited by 9 publications

References 33 publications

Phosphorus Dendrimers for Metal‐Free Ligation: Design of Multivalent Pharmacological Chaperones against Gaucher Disease

Phosphorus Dendrimers for Metal‐Free Ligation: Design of Multivalent Pharmacological Chaperones against Gaucher Disease

Comparative study of the X-ray crystallography temperature, synthesis method, optical properties, NCI-RDG and Hirshfeld surface analyses of coordination polymer of [CuI(DAFO)(SCN)]n: an amenable precursor for CuO nanoparticles

Structure and magnetic properties of a serendipitously synthesized copper(II) complex: [Cu(3-Br-2-pyone)6](ClO4)2

Contact Info

Product

Resources

About