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Emami, Amir; Yaghobi, Ramin; Moattari, Afagh; M, Baseri Salehi; Roozbeh, Jamshid

doi:10.6002/ect.2014.0230

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…i) Regulatory region rearrangements. In BKV, as well as in other polyomaviruses, the regulatory region directs bi-directional gene transcription and genome replication, and is known to undergo complex rearrangements that convert it from “archetype” (basal transmissible form of the virus associated with subclinical infection) to stereotypical “rearranged” variants associated with viremia and disease progression (Emami et al, 2015; Olsen et al, 2009). A great majority of regulatory region sequences in both individuals’ serum/urine at the time of BKVN appeared to represent the archetype arrangement.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution

Peretti

Geoghegan

Pastrana

et al. 2018

Cell Host & Microbe

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BK polyomavirus (BKV) frequently causes nephropathy (BKVN) in kidney transplant recipients (KTRs). BKV has also been implicated in the etiology of bladder and kidney cancers. We characterized BKV variants from two KTRs who developed BKVN followed by renal carcinoma. Both patients showed a swarm of BKV sequence variants encoding non-silent mutations in surface loops of the viral major capsid protein. The temporal appearance and disappearance of these mutations highlights the intra-patient evolution of BKV. Some of the observed mutations conferred resistance to antibody-mediated neutralization. The mutations also modified the spectrum of receptor glycans engaged by BKV during host cell entry. Intriguingly, all observed mutations were consistent with DNA damage caused by antiviral APOBEC3 cytosine deaminases. Moreover, APOBEC3 expression was evident upon immunohistochemical analysis of renal biopsies from KTRs. These results provide a snapshot of in-host BKV evolution and suggest that APOBEC3 may drive BKV mutagenesis in vivo.

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Section: Supplementary Materialsmentioning

confidence: 99%

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution

Peretti

Geoghegan

Pastrana

et al. 2018

Cell Host & Microbe

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“…Rearrangements in NCCR empower viruses with to adjust to novel cellular environments and extend viral tropism and permeability for host cells. These rearrangements also upregulate the viral gene expression and replication compared to the archetype virus (Emami et al, 2017;Zou & Imperiale, 2021).…”

Section: Bkpyv Genome Characteristics In Ktrsmentioning

confidence: 99%

Host and viral RNA dysregulation during BK polyomavirus infection in kidney transplant recipients

2022

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Early detection of BK polyomavirus (BKPyV) infection in kidney transplant recipients (KTRs) would enhance their quality of life and save the allograft.Still, many patients lose their grafted kidneys because of this infection. BKPyV microRNAs (miRNAs) have been detected in KTRs during viral infection.BKPyV produces two mature miRNAs that are named BKV-miR-B1-5p and BKV-miR-B1-3p. Additionally, BKPyV associated nephropathy (BKVAN) in kidney transplanted patients cause changes in the expression level of host genes and miRNAs such as IFN-ɣ, BCLA2A1, has-miR-10, and has-miR-30a. BKVAN can alter viral genes and miRNAs expression level, too, like viral miRNAs and T-Ag. However, their potential value as viral infection markers and the regulatory network produced by their expression during viral-host interactions needs more consideration since there are no approved medications for treating BKPyV-related diseases in KTRs. Hence, it is vital to recognize complicated facts regarding the impact of BKPyV infection on the distribution of miRNAs and mRNAs within the host cell and the virus.

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Survey of BK Virus in Renal Transplant Recipients in Iran: A Systematic Review and Meta-Analysis

et al. 2020

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Introduction: BK virus (BKV) infection in renal transplant (RT) recipients can cause hemorrhagic cystitis, transient renal dysfunction, and BKV nephropathy (BKVN). The prevalence and significance of BKV in RT recipients remain to be clarified in the Iranian population. The purpose of this review is to summarize the overall prevalence of BKV infection in RT recipients from previously published studies in Iran. Methods: We systematically reviewed articles through a comprehensive search of the main electronic and Persian national databases up to November 2019. Results: The overall pooled prevalence of BKV infection among the Iranian population was 23% (95% CI; 15–33%). Comparing these studies revealed that the prevalence of BKV in plasma samples ranges from 3 to 40%, in renal biopsies 1–13%, and in urine samples 10–49%. Due to substantial heterogeneity among reported studies (I2 = 93%, p < 0.01), random-effect meta-analysis was performed. BKV infection rate was slightly higher in women than men (16%, p = 0.04 vs. 14%, p < 0.01, respectively). The majority of the studies employed real-time PCR (24%, I2 = 93, p < 0.01) and analyzed plasma samples alone or in combination with other types of specimens. BKV prevalence from 5 cities among the Iranian population showed a higher prevalence rate in Guilan. Conclusion: Our analysis provides a preliminary estimate of the epidemiology of BKV infection in RT recipients in Iran. These results arouse a need for more epidemiological studies of BKV infection in different unanalyzed regions in Iran. Early detection of BKV in RT recipients helps timely nephropathy diagnosis and prevents graft loss.

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Untitled

Cited by 3 publications

References 32 publications

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution

Host and viral RNA dysregulation during BK polyomavirus infection in kidney transplant recipients

Survey of BK Virus in Renal Transplant Recipients in Iran: A Systematic Review and Meta-Analysis

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