19F-nuclear magnetic resonance spectroscopy as a tool to investigate host-guest complexation of some antidepressant drugs with natural and modified cyclodextrins

Abstract

Purpose: 19 F-Nuclear magnetic resonance spectroscopy ( 19 F-NMR) was used to study host-guest complexation of three fluorine containing antidepressant drugs, viz, fluoxetine hydrochloride, citalopram hydrobromide and fluvoxamine maleate, with various cyclodextrins (CD), including α-, β-cyclodextrin, methylated α-cyclodextrin (M-α-CD), diamino derivative of methylated α-cyclodextrin, (DAM-α-CD) and tetramino derivative of methylated α-cyclodextrin (TAM-α-CD