19F-MRS studies of fluorinated drugs in humans

Wolf, Walter; Presant, Cary A.; Waluch, V.

doi:10.1016/s0169-409x(99)00056-3

Cited by 112 publications

(79 citation statements)

References 86 publications

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“…(i) Imaging techniques. As a conceptual extension of autoradiography (7,145,173), several novel imaging methods that lend themselves to the study of drug distribution in humans were developed (26,53,55,56,57,61,64,74,77,83,88,128,147,150,156,158,182,187). These comprised radiopharmaceutical techniques, such as two-dimensional planar gamma scintigraphy (PGS) (88,174), and three-dimensional techniques, such as single photon emission computed tomography (SPECT) (26,61,77,182), positron emission tomography (PET) (56,57,128,188) (Fig.…”

Section: Methods For Studies Of Target Site Drug Distribution In Antimentioning

confidence: 99%

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Müller

Peña

Derendorf

2004

Antimicrob Agents Chemother

233

201

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Section: Methods For Studies Of Target Site Drug Distribution In Antimentioning

confidence: 99%

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Müller

Peña

Derendorf

2004

Antimicrob Agents Chemother

233

201

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“…Moreover, through the use of magnetic resonance spectroscopy, information on tracer metabolism can be obtained (4). Previous studies in humans have demonstrated in vivo detection of the 19 F signal from anti-cancer agents (5-7) and antidepressants (8,9).…”

mentioning

confidence: 99%

¹⁹F‐lanthanide complexes with increased sensitivity for ¹⁹F‐MRI: Optimization of the MR acquisition

Chalmers

Kenwright

Parker

et al. 2011

Magnetic Resonance in Med

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Fluorine-19 magnetic resonance methods offer advantages for molecular or cellular imaging in vivo due to the absence of radioactivity, lack of naturally occurring background signal, and the ability to easily combine measurements with anatomical MRI. Previous studies have shown that 19 F-MRI sensitivity is limited to millimolar concentrations by slow longitudinal relaxation. In this study, a new class of macrocyclic fluorinated lanthanide complexes is investigated where relaxation rates are significantly shortened by proximity of the fluorine group to a paramagnetic lanthanide ion located within the same molecule. Longitudinal and transverse relaxation rates are field dependent and in the range 50-150 s 21 and 70-200 s 21 , respectively, at 7 T. Relaxation rates in these complexes are a function of the molecular structure and are independent of concentration at biologically relevant levels, so can be used as criteria to optimize imaging acquisition. Phantom experiments at 7 T indicate a lower limit for detection by imaging of 20 mM. Magn Reson Med 66:931-936,

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“…Information about relative amounts of metabolites and changes in them provide insight into physiological changes in the tissues of interest. The use of 19 F MRS to follow the uptake, metabolism, and secretion of fluorinated drugs takes advantage of the relatively high sensitivity of 19 F in the MR experiment and the essential lack of any background signal [88], [89]. Although of lower intrinsic sensitivity, 13 C MRS at natural abundance and with 13 C labeled compounds has proved useful in studies of metabolic pathways [90]- [92].…”

Section: A Obvious Benefitsmentioning

confidence: 99%

The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

Cherry¹,

Louie

Jacobs

2008

Proc. IEEE

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| A number of laboratories and companies are currently exploring the development of integrated imaging systems for magnetic resonance imaging (MRI) and positron emission tomography (PET). Scanners for both preclinical and human research applications are being pursued. In contrast to the widely distributed and now quite mature PET/computed tomography technology, most PET/MRI designs allow for simultaneous rather than sequential acquisition of PET and MRI data. While this offers the possibility of novel imaging strategies, it also creates considerable challenges for acquiring artifact-free images from both modalities. This paper discusses the motivation for developing combined PET/MRI technology, outlines the obstacles in realizing such an integrated instrument, and presents recent progress in the development of both the instrumentation and of novel imaging agents for combined PET/MRI studies. The performance of the first-generation PET/MRI systems is described. Finally, a range of possible biomedical applications for PET/MRI are outlined.

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19F-MRS studies of fluorinated drugs in humans

Cited by 112 publications

References 86 publications

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

¹⁹F‐lanthanide complexes with increased sensitivity for ¹⁹F‐MRI: Optimization of the MR acquisition

The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

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19F-MRS studies of fluorinated drugs in humans

Cited by 112 publications

References 86 publications

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

19F‐lanthanide complexes with increased sensitivity for 19F‐MRI: Optimization of the MR acquisition

The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

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Product

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¹⁹F‐lanthanide complexes with increased sensitivity for ¹⁹F‐MRI: Optimization of the MR acquisition