1990 Volvo Award in Experimental Studies: Anulus Tears and Intervertebral Disc Degeneration

Osti, Orso L.; Vernon‐Roberts, B.; Fraser, Robert D.

doi:10.1097/00007632-199008010-00005

Cited by 205 publications

(186 citation statements)

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“…These findings provide evidence that the healing processes that occur in the outer lamellas after annular injury may not be sufficient for effective reconstitution of the external annulus in degenerated discs. 24,25 Increases in disc degeneration cause larger volumes of herniation type. Studies of Modic endplate changes after lumbar discectomy have shown incremental changes in disc degeneration grade.…”

Section: Discussionmentioning

confidence: 99%

Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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Section: Discussionmentioning

confidence: 99%

Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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“…57,81 Perforation of the endplate from the side of the vertebral body causes nucleus decompression, proteoglycan loss, and internal disruption of the anulus. 57 The anulus disruption model, which simulates a peripheral rim tear, causes subsequent changes in the nucleus and endplate, 30,81,82 and shows that degenerative changes, unlike aging, need not start in the nucleus. Compressive loading of rodent tail discs can result in cell death, impaired matrix synthesis, and disruption of the anulus and vertebral body.…”

Section: Disc Degeneration: Animal Modelsmentioning

confidence: 99%

“…87 The time span for detectable degenerative changes to occur ranges from 1 week for mice 88 to many months for pigs and sheep. 57,81 For comparison, in human adolescents, it takes several years for disc "degeneration" to become apparent after endplate injury, 89 and narrowing in adult human discs progresses at approximately 3% per year. 74 …”

Section: Disc Degeneration: Animal Modelsmentioning

confidence: 99%

What is Intervertebral Disc Degeneration, and What Causes It?

Adams¹,

Roughley²

2006

Spine

1,451

1,288

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“…Any imbalance might lead to impaired functional properties. From a histologic point of view, the occurrence of clefts and tears are the major hallmarks of disc degeneration, [5,6,7,9,10,11,15,18,36,40,41,42,43], but there is very little (almost no) evidence that invading cells might contribute to this process of matrix degradation. Therefore, it can be assumed that local cells are involved in any degradation process.…”

Section: Introductionmentioning

confidence: 99%

2002 SSE Award Competition in Basic Science: Expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption

et al. 2002

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During the process of degeneration, the intervertebral disc (IVD) shows a progressive and significant reduction in height due to tissue resorption. Intradiscal clefts and tears are major hallmarks of disc degeneration. Matrix-degrading enzymes such as matrix metalloproteinases (MMPs) are assumed to play a pivotal role in disc tissue degradation and resorption. The objective of this study was therefore to investigate the potential role of MMPs in extracellular matrix degradation leading to disc degeneration. This study was conducted on 30 formalin-fixed and EDTA-decalcified complete crosssections of lumbar IVDs from cadavers of individuals aged between 0 and 86 years. Tissue sections were used for the immunolocalization of MMPs-1, -2, -3 and -9. The number of labeled cells was assessed by morphometric analyses, and was statistically correlated with the formation of clefts and tears, cellular proliferation, granular matrix changes and mucous degeneration. Furthermore, 30 disc specimens obtained during spinal surgery were used for in situ hybridization of MMP-2 and -3-mRNA. In addition, the enzymatic gelatinolytic activity was determined by in situ zymography in autopsy material. Immunohistochemistry showed the intradiscal expression of all four MMPs, which was confirmed by in situ hybridization, providing clear evidence for the synthesis of the enzymes within nucleus pulposus and annulus fibrosus cells. Gelatinolytic enzymatic activity was verified by in situ zymography. IVDs from infants and young adolescents remained almost completely unlabeled for all MMPs tested, while more MMPs-1 and -3 were seen in disc cells of younger adults than in those of a more advanced age; MMP-2 remained unchanged over the adult age periods, and MMP-9 was expressed in only relatively few cells. This pattern significantly correlated with the occurrence of clefts and tears. This correlation was strongest for MMP-1 (P<0.0001), MMP-2 (P<0.0017) and MMP-3 (P<0.0005) in the nucleus, and MMP-1 (P<0.0001) and MMP-2 (P<0.038) in the annulus. In parallel, the proliferation of disc cells and matrix degeneration (granular changes and mucous degeneration) were related to MMP expression. Likewise, enzymatic activity was seen in association with cleft formation. Our data suggest that major MMPs play an important role in the degradation of the IVD. This is evidenced by the high correlation of MMP expression with the formation of clefts and tears. These findings implicate a leading function for MMPs in IVD degeneration resulting in the loss of normal disc function, eventually leading to low-back pain.

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1990 Volvo Award in Experimental Studies: Anulus Tears and Intervertebral Disc Degeneration

Cited by 205 publications

References 0 publications

Factors that influence recurrent lumbar disc herniation

Factors that influence recurrent lumbar disc herniation

What is Intervertebral Disc Degeneration, and What Causes It?

2002 SSE Award Competition in Basic Science: Expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption

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