Abstract:Aim: The aim of this study is to prepare quaternary inclusion complex (QIC) comprised of domperidone (DOM), β-cyclodextrin (βCD), citric acid (CA), and mannitol and to evaluate its efficiency to enhance the solubility and dissolution rate of DOM. Materials and Methods: The phase solubility studies were conducted in water and CA solutions (10 mM) in the presence and absence of mannitol (1%). The physical mixtures and kneaded complexes of DOM/βCD, DOM/βCD/CA, and DOM/βCD/CA/mannitol were prepared for comparative… Show more
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