(190) Effects of sleep continuity disruption on cold pain tolerance and accompanying pain catastrophizing in healthy, good sleepers

Modalen, E.; Hand, Matthew; Remeniuk, Bethany; Perry, Sander I. B.; Swedberg, L.; Pressman, A.; Smith, Michael T.; Finan, Patrick H.

doi:10.1016/j.jpain.2016.01.093

Cited by 1 publication

(1 citation statement)

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“…(Atkinson, Ancoli-Israel, Slater, Garfin, & Gillin, 1988). Primary insomnia prevalence is estimated at about 15 -30% in different societies (Campbell et al, 2015;Cheatle, Foster, Pinkett, Lesneski, Qu, & Dhingra 2016;Modalen et a l., 2016). Comorbid insomnia prevalence in patients suffering from chronic pain is around 50%.…”

Section: Introductionmentioning

confidence: 99%

Intra-cerebroventricular Administration of Crocin Attenuates Sleep Deprivation-induced Hyperalgesia in Rats

Rezaei

Saebipour

Ghaemi

et al. 2020

Basic Clin. Neurosci. J.

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Sleep deprivation can cause hyperalgesia and interfere with analgesic treatments. The aim of the present study was to establish an obligatory sleep-abstinence model and also evaluate the effects of Intracerebroventricular (ICV) injection of crocin on pain perception in Wistar rats. Methods: In this experimental study, 35 adult male Wistar rats were randomly divided into 5 groups (n=7). The intra-ventricular cannulation was done for all rats before sleep deprivation. Sleep deprivation was performed by placing animals on a chamber equipped with an automatic animated conveyor (5 s with an interval of 3 min) for 72 h. Subsequently, the sleep-deprived animals received ICV injection of saline (MOD), Morphine 10 µg (MOR), Crocin 10 ug (Cr10), and Crocin40 µg (Cr40) using a microsyringe. Besides, a non-sleep-deprived group was allocated as a Control Group (NC) and only received an ICV injection of saline. Fifteen minutes after the ICV injections, pain perception was evaluated by the hot plate test (54±0.4 • C). Results: Compared with the NC group, latency significantly decreased in the MOD group (6.28±0.48 vs. 4.28± 0.48, P<0.0001). In comparison with the MOD group, both morphine (8.42±1.53) and crocin (7.60±1.45 for Cr10 and 8.14±0.89 for Cr40) could significantly increase latency in the sleep-deprived animals (P<0.0001). There was no statistically significant difference between the Cr10 and Cr40 (P=0.42), Cr10, and MOR (P=0.059) and Cr40 with MOR (P=0.86) groups. Conclusion: Our results indicated that crocin could attenuate hyperalgesia induced by sleep deprivation in rats.

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