“…To check the status the bone matrix we used SEM to examine the bone ultrastructure. Recently, we studied the role of hormones and other molecules in bone ultrastructure in murine models using both microCT and DXA along with classical histochemical, molecular, and biochemical methods [26,34,35]. Both SEM and TEM can explain bone matrix changes during osteopenia/osteoporotic that cannot be seen in vivo.…”