18fdg-Pet-Ct

Muller, H; Viaccoz, Aurélien; Fisch, Loraine; Bonvin, Christophe; Lövblad, Karl-Olof; Ratib, Osman; Lalive, Patrice H.; Pagano, Sabrina; Vuilleumier, Nicolas; Willi, Jean-Pierre; Sztajzel, Roman

doi:10.1161/strokeaha.114.006488

Cited by 27 publications

(13 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4. PET-CT supports and demonstrates the inflammationischemia relationship by revealing pro-inflammatory macrophages in the atherosclerotic plaque (18fluorodeoxyglucose capture is directly proportional to the number of macrophages present in the atheroma plate) [8][9][10].…”

mentioning

confidence: 76%

C-Reactive Protein - A Predictable Biomarker in Ischemic Stroke

Totan¹,

Antonescu²,

Catana³

et al. 2019

Rev. Chim.

View full text Add to dashboard Cite

C-reactive protein (CRP) is a non-specific inflammatory marker, correlated with the severity and prognosis of ischemic stroke. We performed a retrospective study in which were included 81 patients diagnosed with acute ischemic stroke admitted between January and July 2017 in the Department of Neurology, Sibiu Emergency Clinical Hospital. CRP values were classified on three levels (0 - 5 mg / L, 5 - 50 mg / l and] 50 mg / l). We examined the correlation between CRP levels according to the type of ischemic (lacunar / territorial) stroke, the degree of motor deficit (quantified by the mRC scale), the associated risk factors and the mortality rate. PCR values above 50 mg / L were found in patients with territorial stroke (15%). Moderate motor deficits predominate, with PCR values ranging from 5-50 mg / L. The most important risk factors found in the patients included in our study were hypertension and atherosclerosis. We made correlations between these risk factors and the PCR values. In most cases with these two risk factors were recorded a mean PCR value (5-50 mg / L).For atherosclerosis the results were statistically significant, p = 0.021. Most patients (56%) had CRP levels ranging from 5 to 50 mg / L. These values recorded highest death rates. PCR it is an important marker of inflammation and it is important to be determined in all patients with acute ischemic stroke, especially which is thought to be correlated with the prognosis of these patients.

show abstract

mentioning

confidence: 76%

C-Reactive Protein - A Predictable Biomarker in Ischemic Stroke

Totan¹,

Antonescu²,

Catana³

et al. 2019

Rev. Chim.

View full text Add to dashboard Cite

show abstract

“…Several studies recently assessed the diagnostic potential of using 18 F-fluorodeoxyglucose PET ( 18 F-FDG PET) or 18 F-FDG PET/CT to evaluate plaque inflammation, and promising results have been reported. These studies report that 18 F-FDG PET or 18 F-FDG PET/CT can accurately detect high-risk carotid plaques [ 129 - 131 ] ( Figure 14 ). There are significant correlations between the histologic findings and degree of inflammation on 18 F-FDG [ 132 , 133 ].…”

Section: Vessel Wall Imaging Techniquesmentioning

confidence: 99%

Vessel Wall Imaging of the Intracranial and Cervical Carotid Arteries

2015

View full text Add to dashboard Cite

Vessel wall imaging can depict the morphologies of atherosclerotic plaques, arterial walls, and surrounding structures in the intracranial and cervical carotid arteries beyond the simple luminal changes that can be observed with traditional luminal evaluation. Differentiating vulnerable from stable plaques and characterizing atherosclerotic plaques are vital parts of the early diagnosis, prevention, and treatment of stroke and the neurological adverse effects of atherosclerosis. Various techniques for vessel wall imaging have been developed and introduced to differentiate and analyze atherosclerotic plaques in the cervical carotid artery. High-resolution magnetic resonance imaging (HR-MRI) is the most important and popular vessel wall imaging technique for directly evaluating the vascular wall and intracranial artery disease. Intracranial artery atherosclerosis, dissection, moyamoya disease, vasculitis, and reversible cerebral vasoconstriction syndrome can also be diagnosed and differentiated by using HR-MRI. Here, we review the radiologic features of intracranial artery disease and cervical carotid artery atherosclerosis on HR-MRI and various other vessel wall imaging techniques (e.g., ultrasound, computed tomography, magnetic resonance, and positron emission tomography-computed tomography).

show abstract

“…However, it has been repeatedly reported that arterial calcification does not always accord with FDG uptake ( 37 38 39 ), probably because FDG uptake reflects the present activity whereas calcifications on CT are the end-products of inflammation. Consequently, FDG uptake is related to cardiovascular events or stroke ( 40 41 ), and probably is a better predictor for vascular events than calcifications on CT ( 42 ). Based on this background, FDG PET has been used for assessing inflammation activity in the case of drug treatment ( 43 44 ).…”

Section: Imaging Methodsmentioning

confidence: 99%

“…However, there is no consensus for the selection of an appropriate quantitative index for atherosclerosis, in contrast to cancers where the maximal SUV is commonly utilized as an index reflecting the most malignant components of a lesion. Among reported FDG PET studies on plaque imaging, some adopted the maximal SUV ( 32 38 39 41 42 ), whereas others adopted the mean SUV as a quantitative index ( 33 36 40 94 ). Based on these values, additional semi-quantitative indices were calculated, such as the target-to-reference tissue ratio (TRR; also called target-to-background ratio, TBR) or the lesion-to-normal ratio (LNR) ( Table 1 ).…”

Section: Considerations Regarding Imaging Technologymentioning

confidence: 99%

Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques

Lee

Paeng

2015

Korean J Radiol

View full text Add to dashboard Cite

Atherosclerosis is an inflammatory disease as well as a lipid disorder. Atherosclerotic plaque formed in vessel walls may cause ischemia, and the rupture of vulnerable plaque may result in fatal events, like myocardial infarction or stroke. Because morphological imaging has limitations in diagnosing vulnerable plaque, molecular imaging has been developed, in particular, the use of nuclear imaging probes. Molecular imaging targets various aspects of vulnerable plaque, such as inflammatory cell accumulation, endothelial activation, proteolysis, neoangiogenesis, hypoxia, apoptosis, and calcification. Many preclinical and clinical studies have been conducted with various imaging probes and some of them have exhibited promising results. Despite some limitations in imaging technology, molecular imaging is expected to be used both in the research and clinical fields as imaging instruments become more advanced.

show abstract

18fdg-Pet-Ct

Cited by 27 publications

References 41 publications

C-Reactive Protein - A Predictable Biomarker in Ischemic Stroke

C-Reactive Protein - A Predictable Biomarker in Ischemic Stroke

Vessel Wall Imaging of the Intracranial and Cervical Carotid Arteries

Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques

Contact Info

Product

Resources

About