[18F]-NaF PET/CT imaging in cardiac amyloidosis

Gucht, Axel Van Der; Galat, Arnault; Rosso, Jean; Guellich, Aziz; Garot, Jérôme; Bodez, Diane; Planté‐Bordeneuve, Violaine; Hittinger, Luc; Dubois‐Randé, Jean‐Luc; Evangelista, Eva; Sasanelli, Myriam; Chalaye, Julia; Meignan, Michel; Itti, Emmanuel; Damy, Thibaud

doi:10.1007/s12350-015-0287-0

Cited by 51 publications

(16 citation statements)

References 5 publications

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“…As a potential PET substitute for bisphosphonate-based tracers, general feasibility of amyloid imaging using [ 18 F]NaF has been described in single case series whereas another report failed to identify increased tracer uptake in ATTR patients [125–127]. Further studies are needed to further investigate the potential value of [ 18 F]NaF PET in CA.…”

Section: Cardiac Amyloidosismentioning

confidence: 99%

Novel Noninvasive Nuclear Medicine Imaging Techniques for Cardiac Inflammation

Kircher

Lapa

2017

Curr Cardiovasc Imaging Rep

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Purpose of ReviewInflammation is a key player in a wide range of cardiovascular and myocardial diseases. Given the numerous implications of inflammatory processes in disease initiation and progression, functional imaging modalities including positron emission tomography (PET) represent valuable diagnostic, prognostic, and monitoring tools in patient management. Since increased glucose metabolism is a hallmark of inflammation, PET using the radiolabeled glucose analog [18F]-2-deoxy-2-fluoro-d-glucose (FDG) is the mainstay diagnostic test for nuclear imaging of (cardiac) inflammation. Recently, new approaches using more specific tracers to overcome the limited specificity of FDG have emerged.Recent FindingsPET imaging has proven its value in a number of inflammatory conditions of the heart including myocarditis, endocarditis, sarcoidosis, or reactive changes after myocardial infarction. In infection-related endocarditis, FDG-PET and white blood cell scintigraphy have been implemented in current guidelines. FDG-PET is considered as nuclear medical gold standard in myocarditis, pericarditis, or sarcoidosis. Novel strategies, including targeting of somatostatin receptors or C-X-C motif chemokine receptor CXCR4, have shown promising results in first studies.SummaryNuclear medicine techniques offer valuable information in the assessment of myocardial inflammation. Given the possibility to directly visualize inflammatory activity, they represent useful tools for diagnosis, risk stratification, and therapy monitoring.

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Section: Cardiac Amyloidosismentioning

confidence: 99%

Novel Noninvasive Nuclear Medicine Imaging Techniques for Cardiac Inflammation

Kircher

Lapa

2017

Curr Cardiovasc Imaging Rep

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“…Recent reports using PET imaging have demonstrated promise in subtyping CA [66–68]. In a case study using (18)F- NaF, also a bone seeking tracer, diffuse myocardial enhancement was observed in a patient with ATTRm (Val122Ile) with no uptake in a patent with AL [66].…”

Section: Subtypingmentioning

confidence: 99%

Transthyretin Cardiac Amyloidosis in Older Adults: Optimizing Cardiac Imaging to the Corresponding Diagnostic and Management Goal

Castaño

Manson

Maurer

et al. 2017

Curr Cardiovasc Risk Rep

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Purpose of review Transthyretin cardiac amyloidosis is increasingly recognized as an important cause of heart failure in older adults. Many cardiac imaging modalities have evolved to evaluate transthyretin cardiac amyloidosis and include 2D echocardiography with tissue Doppler and speckle-strain imaging, nuclear scintigraphy, cardiac magnetic resonance imaging, and positron emission tomography. The purpose of this review is to highlight the optimal selection of advanced cardiac imaging techniques with corresponding diagnostic goals including raising suspicion, making an early diagnosis, and subtyping transthyretin cardiac amyloid, as well as management goals including assessment of ventricular impairment, prognosticating, and monitoring disease progression. Potential benefits of optimizing cardiac imaging in the elderly patient with transthyretin cardiac amyloidosis may include enhanced and earlier diagnosis and refined long-term management. Recent findings Advances in cardiac imaging techniques are changing diagnostic and management algorithms for transthyretin cardiac amyloidosis. Summary With a new era of novel therapeutics, enhanced recognition, and earlier diagnosis approaching, selecting the appropriate non-invasive cardiac imaging modality will be essential for optimal care in the elderly patient with transthyretin cardiac amyloidosis.

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“…In one pilot study, the use of 18F-NaF PET/CT was evaluated to differentiate AL from ATTR CA and reported positive myocardial uptake in a patient with Val122Ile TTR mutation and no uptake in the AL patient [57]. Subsequently, one study evaluated a patient with wild-type TTR and another with Ile68Leu TTR mutation and found no myocardial uptake in either [58].…”

Section: Introductionmentioning

confidence: 99%

Role of Imaging in Evaluating Infiltrative Heart Disease

Divakaran

Singh

Collins

et al. 2017

Curr Treat Options Cardio Med

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Opinion statement Infiltrative heart disease is caused by the deposition of abnormal substances in the heart and can lead to abnormalities in cardiac function and electrical conduction. Advances in non-invasive cardiovascular imaging have allowed for improved diagnosis of infiltrative heart disease, as well as ways to track disease progression or regression, thus enabling a mechanism to follow response to therapy. In this review, we provide an overview of the role of imaging in the diagnosis and management of cardiac sarcoidosis (CS) and cardiac amyloidosis (CA), as well as outline a proposed algorithm for using non-invasive cardiovascular imaging for evaluating these conditions.

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[18F]-NaF PET/CT imaging in cardiac amyloidosis

Cited by 51 publications

References 5 publications

Novel Noninvasive Nuclear Medicine Imaging Techniques for Cardiac Inflammation

Novel Noninvasive Nuclear Medicine Imaging Techniques for Cardiac Inflammation

Transthyretin Cardiac Amyloidosis in Older Adults: Optimizing Cardiac Imaging to the Corresponding Diagnostic and Management Goal

Role of Imaging in Evaluating Infiltrative Heart Disease

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