18F-fluoromisonidazole positron emission tomography before treatment is a predictor of radiotherapy outcome and survival prognosis in patients with head and neck squamous cell carcinoma

Abstract

Radiotherapy outcome and survival prognosis (radiotherapy or operation) in HNSCC may be predicted by carrying out [(18)F]FMISO PET before treatment.

Hypoxia as a Biomarker and for Personalized Radiation Oncology

“…The majority of studies involved FMISO measurements in head-and-neck cancer patients (Rajendran et al 2006;Rischin et al 2006;Thorwarth et al 2006;Eschmann et al 2007;Dirix et al 2009;Lee et al 2009;Kikuchi et al 2011;Zips et al 2012). Two other studies in head and neck used either FETNIM (Lehtio et al 2004) or FAZA .…”

Improving chemoradiation efficacy by PI3-K/AKT inhibition

“…Especially repeated hypoxic scans, before and during treatment, could give valuable information about the efficacy of PI3-K/AKT inhibition. Clinical studies in head and neck cancer patients have already shown that FMISO-PET uptake before or during radiotherapy correlates with outcome [120,121].…”

Positron emission tomography to assess hypoxia and perfusion in lung cancer

“…Koh et al [221] , Liu et al [222] , Yeh et al [223] , Rischin et al [224] , Bentzen et al [125] , Rajendran et al [225] , Gagel et al [126] , Rajendran et al [226] , Hicks et al [227] , Lawrentschuk et al [200] , Loi et al [228] , Thorwarth et al [229] , Rajendran et al [230] , Rischin et al [231] , Thorwarth et al [232] , Zimny et al [124] , Eschmann et al [233] , Gagel et al [202] , Thorwarth et al [234] , Thorwarth et al [235] , Lee et al [236] , Lin et al [237] , Nehmeh et al [238] , Roels et al [239] , Dirix et al [240] , Lee et al [241] , Mortensen et al [127] , Wang et al [56] , Abolmaali et al [242] , Bowen et al [138] , Eary et al [243] , Kikuchi et al [244] , Hugonnet et al [131] , Yamane et al [245] , Mammar et al [246] , Zips et al [247] , Cheng et al [217] , Henriques de Figueiredo et al [248] , Okamoto et al [249] , Sato et al [218] , Segard et al [250] , Tachibana et al [251] , Norikane et al [219] [ Dubois et al …”