[18F]fluorodeoxyglucose positron emission tomography is a useful tool to diagnose the early stage of Takayasu's arteritis and to evaluate the activity of the disease

Umekita, Kunihiko; Takajo, Ichiro; Miyauchi, Syunichi; Tsurumura, Katoko; Ueno, Siro; Kusumoto, Norio; Yu, Kai; Kuroki, M; Sasaki, Takashi; Okayama, Akira

doi:10.1007/s10165-006-0485-3

Cited by 20 publications

(13 citation statements)

References 16 publications

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“…The sensitivity and specificity of FDG PET in detection of vasculitis have been reported to be 77-100% and 89-100%, respectively (21). CT and MRI are employed for diagnosis of Takayasu arteritis, however, FDG PET has been found to be more effective especially for lesions of early stage (22). In the current study, vasculitis was diagnosed in all the 3 patients with noninfectious inflammatory causes.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Role of FDG PET/CT in Patients with Fever of Unknown Origin

Ergül¹,

Halaç²,

Çermik³

et al. 2011

Mirt

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Objective: Fever of unknown origin (FUO) is a challenge for the physician and needs use of clinical, laboratory, and imaging studies and also invasive and/or non-invasive interventions to detect the etiology. The aim of present study was to assess the role of FDG PET/CT in determining the etiology in patients with FUO.Material and Methods: Twenty-four patients (median age 52, range 5-77 years, 6 female, 18 male) who were diagnosed with FUO were retrospectively analyzed in this study. Before the FDG PET/CT studies, none of them had a definitive reason for their diseases investigated by conventional radiological or scintigraphic methods, clinical and laboratory observations. Results: The positive result was achieved in 19 (79.2%) of 24 patients as findings of the FDG PET/CT. However, FDG PET/CT was useful for definitive diagnosis in 12 (63.2%) of 19 positive patients. Malignant diseases were determined to be the underlying cause of FUO in 5 (41.6%) of 12 patients. Noninfectious inflammatory causes were detected in 2 (16.7%) patients, infections were exhibited in 3 (25%) patients, and miscellaneous diseases demonstrated in 2 (16.7%) patients. In 7 patients the detected pathological uptakes on FDG PET/CT were not helpful for the definitive diagnosis. In remaining 5 patients who showed no pathological uptake in the FDG PET/CT, diagnosis could not be established by other methods, as well. The sensitivity, specificity, and positive and negative predictive values for the determination of FUO etiology were 92.3%, 45.4%, 63.1%, and 100% for FDG PET/CT.Conclusion: Our results demonstrate that FDG PET/CT seems to have considerable contribution to reveal the reason of undiagnosed patients with FUO investigated by conventional diagnostic methods, clinical and laboratory observations. Conflict of interest:None declared.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Role of FDG PET/CT in Patients with Fever of Unknown Origin

Ergül¹,

Halaç²,

Çermik³

et al. 2011

Mirt

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“…For example, in elderly patients, 18 F-FDG-PET cannot distinguish between TA and atherosclerosis [54,55,60]. Therefore, its clinical application value still needs further studies to confirm.…”

Section: F-fdg-petmentioning

confidence: 94%

Takayasu Arteritis: Diagnosis, Treatment and Prognosis

Wen

2012

International Reviews of Immunology

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Takayasu arteritis (TA) is a chronic nonspecific granulomatous vasculitis affecting aorta and its main branches, coronary and pulmonary arteries. TA often occurs in young women and has a characteristic heterogeneity depending on ethnicity and geographical location. Although the pathogenesis of TA remains unclear, the interaction of many factors, such as autoimmunity, inflammation, genetic and environmental factors and so on, is involved in the occurrence and development of TA. Angiography, which is recognized as the gold standard in evaluating vascular lesions in TA, combined with computer tomography angiography (CTA), magnetic resonance angiography (MRA), ultrasonography, (18)Fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) could not only provide important information for early diagnosis but also detect disease activity, and thus further guide the treatment in TA. In addition, beside the commonly used corticosteroids, immunosuppressive agents, percutaneous transluminal angioplasty (PTA) and surgical revascularization, anti-tumor necrosis factor (TNF) agent has been more widely used in refractory cases of TA. The objective of this review is to systemically describe the pathogenesis, clinical characteristics, diagnosis, treatment and prognosis of TA.

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“…Accumulation of the radiolabelled deoxyglucose can delineate areas of inflammation and the extent of the disease involvement. It is hoped that this method in conjunction with either CT or MRI can be used to screen for early disease 39 40. The disadvantage is that the PET scan is not specific for vasculitis, involves a significant radiation dose and is limited to larger centres 41…”

Section: Diagnostic Imagingmentioning

confidence: 99%