“…3A). As observed in earlier studies 17,19,38,53,54 , as a consequence of cocaine exposure, average body weight was higher in the cocaine-naïve AgeControl group compared to 0crit and 3crit, but it remained stable in each group throughout the www.nature.com/scientificreports/ performed two ad-libitum CSA sessions: one before and one after MnCl 2 administration. As expected, addictlike rats (3crit) earned more infusions than non-addict-like rats (0crit) at both time points but importantly, the responses and reinforcers earned during these self-administration tests were similar before and after MnCl 2 treatment (group effect [F(1,34) = 9.11; p = 0.0048], time effect [F(1,34) = 1.11; p = 0.3], group by time interaction [F(1,34) = 0.38; p = 0.54], Fig.…”