18F-Fluorodeoxyglucose positron emission tomography and infectious diseases: current applications and future perspectives

Bassetti, Matteo; Carnelutti, Alessia; Muser, Daniele; Righi, Elda; Petrosillo, Nicola; Gregorio, Fernando Di; Werner, Thomas; Alavi, Abass

doi:10.1097/qco.0000000000000354

Cited by 12 publications

(13 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Combined anatomic and functional imaging with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is slowly gaining a foothold in the management of invasive fungal infections [ 55 ]. In current clinical practice, standalone FDG-PET/CT is not generally sufficient to differentiate IPA from malignancy or other active inflammatory lesions, such as active tuberculosis [ 55 ]. However, significant different FDG-PET/CT patterns in invasive and non-invasive forms of aspergillosis have been described [ 56 ].…”

Section: Radiological Diagnosismentioning

confidence: 99%

Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review

2017

Self Cite

View full text Add to dashboard Cite

Invasive aspergillosis (IA) is a serious opportunistic infection, which has increasingly been recognized as an emerging disease of non-neutropenic patients. In this group of patients, the diagnosis of IA can be challenging owing to the lack of specificity of symptoms, the difficulty in discriminating colonization from infection, and the lower sensitivity of microbiological and radiological tests compared with immunocompromised patients. The aim of this article is to present to clinicians a critical review on the management of IA in non-neutropenic patients.

show abstract

Section: Radiological Diagnosismentioning

confidence: 99%

Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review

2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…When evaluating a patient with potential implant infection, the surgeon is limited by three key factors. First, it is impossible to confidently discriminate infection from aseptic loosening due to limitations in current imaging modalities, including metal artifacts from the implant (15)(16)(17)(18)(19)(20)(21)(22). Second, the surgeon cannot differentiate S. aureus from other bacteria, a distinction that affects management and prognosis; species-specific intraoperative antimicrobial adjuvants can only be utilized if the bacteria is diagnosed prior to completing the operation (9, 11, 12).…”

Section: Discussionmentioning

confidence: 99%

“…implants and have limited utility due to metal artifacts that obscure the bone-implant interface (15)(16)(17)(18). Clinical algorithms that combine PET imaging with fluorine-18-fluorodeoxyglucose ( 18 F-FDG) can be employed (19), but 18 F-FDG accumulates at sites of both infectious and aseptic inflammation (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Zoller¹,

Park²,

Olafsen³

et al. 2019

JCI Insight

View full text Add to dashboard Cite

KPF report that they are employees of PerkinElmer, a manufacturer of optical and PET imaging equipment. LSM reports that he has received grant support from MedImmune, Pfizer, Moderna Therapeutics, Regeneron Pharmaceuticals, and Boehringer Ingelheim and consulting fees from Integrated BioTherapeutics, related to Staphylococcus aureus vaccines and therapeutics. JMVD reports that he has filed a patent application (WO2015/088346) on the use of 1D9, which is owned by his employer University Medical Center Groningen. NMB reports that he has received consulting fees from Zimmer Biomet, Bonesupport, Daiichi Sankyo, and Onkos and that he is a board or committee member of the Musculoskeletal Tumor Society and Orthopaedic Research and Education Foundation.

show abstract

“…Дополнительным методом диагностики служит КТ-ангиография, которая позволяет диагностировать признаки сосудистой инвазии и окклюзии; чувствительность и специфичность этого метода -0,94 и 0,71 соответственно [34]. Использование позитронно-эмиссионной томографии с 18F-фтордезоксиглюкозой не позволяет в полной мере дифференцировать ИА легких от других воспалительных очагов или метастатического поражения [35].…”

Section: рисунокunclassified

Invasive aspergillosis in children in debut of acute myeloid leukemia

Диникина

Шадривова

Белогурова

et al. 2019

Voprosy gematologii/onkologii i immunopatologii v pediatrii

View full text Add to dashboard Cite

Invasive aspergillosis (IA) is a life-threatening complication in pediatric patients with hematological malignancies. The highest incidence rates of IA were found in pediatric patients with acute myeloid leukemia (AML). We presented a case of successful treatment of IA in a patient with debut of AML with Down syndrome, analysis of IA cases in children with AML according data of the register and a literature review. 46 pediatric patients with IA were included, among them 16 (34.7%) with AML. In 3 (18.75%) pts AML was diagnosed in presentation of AML. Risk factors of IA were prolonged neutropenia (100%) and lymphocytopenia (81%). The most common clinical signs were: fever > 38.5 ºС (93.7%), cough (75%) and respiratory failure (43.7%). The lung involvement was diagnosed in 93.7% of pts, more than 2 sites of IA – in 12.5%, endophthalmitis – in 6.25%. Typical imaging finding was «halo sign» – 37.5%. According received results «probable IA» was diagnosed in 87.5% of pts and «proven» in 12.5%. Antifungal treatment received 100% of patients, with voriconazole only – 50%, combined antifungal therapy – 33.3%. Overall 12-week survival was 87.5%. Parents patients agreed to use personal data in research and publications.

show abstract

18F-Fluorodeoxyglucose positron emission tomography and infectious diseases: current applications and future perspectives

Abstract: In this article, we summarize the available evidence and potential future applications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis and management of infectious diseases.

Cited by 12 publications

References 77 publications

Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review

Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review

Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Invasive aspergillosis in children in debut of acute myeloid leukemia

Contact Info

Product

Resources

About