18F-fluorodeoxyglucose PET/CT findings in a systemic inflammatory response syndrome after COVID-19 vaccine

Steinberg, Julie; Thomas, Alex; Iravani, Amir

doi:10.1016/s0140-6736(21)00464-5

Cited by 43 publications

(42 citation statements)

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“…Overall, these articles are mainly case reports or small case series recently published by research groups from different countries worldwide reporting PET findings in COVID-19 vaccine recipients who underwent PET/CT or PET/MRI with different radiotracers for several indications [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] (Table 1). Most of the described patients underwent vaccination against COVID-19 from 1 day to 3 weeks before 18 F-FDG PET/CT.…”

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confidence: 99%

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PET findings after COVID-19 vaccination: “Keep Calm and Carry On”

Treglia

Cuzzocrea

Muoio

et al. 2021

Clin Transl Imaging

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confidence: 99%

“…Less frequently, diffuse splenic 18 F-FDG-uptake was also described. All these described sites of increased radiopharmaceutical uptake were interpreted as reactive due to immune response after recent vaccination against COVID-19 [2-10, [12][13][14][15][17][18][19][20][21].…”

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confidence: 99%

PET findings after COVID-19 vaccination: “Keep Calm and Carry On”

Treglia

Cuzzocrea

Muoio

et al. 2021

Clin Transl Imaging

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“…Such dilemma can be critical for oncologic patients who might lose a chance of curative surgery due to false-positive FDG uptake at distant sites. Several case reports of lymphadenopathy post-COVID-19 vaccination have been published recently (5)(6)(7)(8). In this case report, we present the case of axillary and supraclavicular lymphadenopathies detected on FDG PET/CT during a staging work-up for rectosigmoid colon cancer.…”

Section: Introductionmentioning

confidence: 88%

FDG Uptakes at Unilateral Axillary and Supraclavicular Lymph Nodes and Deltoid Muscle on [18F] FDG PET/CT After COVID-19 Vaccination: A Potential Pitfall for Metastatic Lymph Nodes in Colon Cancer Patient

Choi¹,

Kim²

2021

Korean J Abdom Radiol

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing global pandemic. It can manifest a wide range of complications depending upon the severity of infection and comorbidities of the patient. Vaccines are very important measure to provide protection against COVID-19. We report a case of 73-year-old female who underwent [<sup>18</sup>F]F-2-fluoro-2-deoxyd-glucose (FDG) positron emission tomography/computed tomography (PET/CT) and contrast-enhanced CT for staging of her rectosigmoid colon cancer and was found to have hypermetabolic uptakes in the deltoid muscle of the left shoulder and hypermetabolic left axillary and supraclavicular lymph nodes due to adenovirus vectored vaccine (ChAdOx1 nCoV-19, AstraZeneca) administrated 18 days ago prior to PET/CT scan.

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“…Previous invasive methods of studying the structure and function of CNS do not apply to the human body. Emerging molecular functional imaging technology PET/CT is mainly used to diagnose and evaluate tumors, infectious diseases (12), and central nervous system diseases (13), such as lung cancer (14), lymphoma (15), etc. al.…”

Section: Introductionmentioning

confidence: 99%

Neuropeptide Y Plays an Important Role in the Relationship Between Brain Glucose Metabolism and Brown Adipose Tissue Activity in Healthy Adults: A PET/CT Study

et al. 2021

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IntroductionBrown adipose tissue (BAT) becomes the favorite target for preventing and treating metabolic diseases because the activated BAT can produce heat and consume energy. The brain, especially the hypothalamus, which secretes Neuropeptide Y (NPY), is speculated to regulate BAT activity. However, whether NPY is involved in BAT activity’s central regulation in humans remains unclear. Thus, it’s essential to explore the relationship between brain glucose metabolism and human BAT activity.MethodsA controlled study with a large sample of healthy adults used Positron emission tomography/computed tomography (PET/CT) to noninvasively investigate BAT’s activity and brain glucose metabolism in vivo. Eighty healthy adults with activated BAT according to the PET/CT scan volunteered to be the BAT positive group, while 80 healthy adults without activated BAT but with the same gender, similar age, and BMI, scanning on the same day, were recruited as the control (BAT negative). We use Statistical parametric mapping (SPM) to analyze the brain image data, Picture Archiving & Communication System (PACS), and PET/CT Viewer software to calculate the semi-quantitative values of brain glucose metabolism and BAT activity. ELISA tested the levels of fasting plasma NPY. The multiple linear regression models were used to analyze the correlation between brain glucose metabolism, the level of NPY, and the BAT activity in the BAT positive group.Results(1) Compared with controls, BAT positive group showed significant metabolic decreases mainly in the right Insula (BA13a, BA13b) and the right claustrum (uncorrected P <0.01, adjusted BMI). (2) The three brain regions’ semi-quantitative values in the BAT positive group were significantly lower than the negative group (all P values < 0.05). (3) After adjusting for age, gender, BMI, and outside temperature, there was a negative correlation between brain metabolic values and BAT activity (all P values < 0.05). However, after further adjusting for NPY level, there were no significant differences between the BA13b metabolic values and BAT activity (P>0.05), while the correlation between the BA13a metabolic values and BAT activity still was significant (P< 0.05).ConclusionsRegional brain glucose metabolism is closely related to healthy adults’ BAT activity, which may be mediated by NPY.

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18F-fluorodeoxyglucose PET/CT findings in a systemic inflammatory response syndrome after COVID-19 vaccine

Cited by 43 publications

References 0 publications

PET findings after COVID-19 vaccination: “Keep Calm and Carry On”

PET findings after COVID-19 vaccination: “Keep Calm and Carry On”

FDG Uptakes at Unilateral Axillary and Supraclavicular Lymph Nodes and Deltoid Muscle on [18F] FDG PET/CT After COVID-19 Vaccination: A Potential Pitfall for Metastatic Lymph Nodes in Colon Cancer Patient

Neuropeptide Y Plays an Important Role in the Relationship Between Brain Glucose Metabolism and Brown Adipose Tissue Activity in Healthy Adults: A PET/CT Study

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