18F-Fluorodeoxyglucose PET/Computed Tomography in the Diagnosis and Monitoring of Giant Cell Arteritis

Nielsen, Berit Dalsgaard; Gormsen, Lars Christian

doi:10.1016/j.cpet.2019.11.007

Cited by 12 publications

(13 citation statements)

References 81 publications

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“…FDG-PET has been shown to be accurate to detect C-GCA and LV-GCA [7][8][9][10]14]. In the present study, using grading scores including cranial arteries (20-segment and cranial) allowed us to increase diagnostic performance of FDG-PET, in comparison with subjective analysis as well as TVS, especially in terms of sensitivity (80% vs 73%).…”

Section: Discussionmentioning

confidence: 72%

Diagnostic performance of digital PET with a dedicated head and neck protocol for the assessment of cranial arteries inflammation in Giant Cell Arteritis

Durand-Bailloud

Samson

Bertaut

et al. 2022

Preprint

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Introduction Giant cell arteritis (GCA) is a frequent granulomatous vasculitis. In the diagnosis of large vessel GCA, FDG-PET/CT imaging has been recommended and its use has steadily increased. The objective of this prospective study was to evaluate the diagnostic performance of digital FDG-PET imaging with a head and neck dedicated protocol, especially to detect cranial arteries involvement, using different visual grading scores, and to assess the inter-reader agreement. Material and Methods FDG-PET/CT scans with a 10-min acquisition time on the head and neck were performed in patients suspected of having recent GCA. A score including 20 segments due to the inclusion of cranial segments and a score established only for the cranial segments were compared to the Total Vascular Score (TVS) established on 7 arterial segments. These scores were assessed by two nuclear medicine physicians on a blinded manner and, in case of disagreement, a consensus was established with a third nuclear medicine physician. Results GCA diagnosis was retained for 15 of the 52 patients included. Sensitivity and specificity of the 20-segment or the cranial scores were higher than those of TVS (sensitivity and specificity of 80% of 97% for both scores vs 73% and 89% for TVS, respectively). The inter-reader agreement was substantial in the 20-segment score (weighted kappa = 0.68) but better in the cranial segments than other segments. Conclusion This study shows the usefulness of grading scores able to highlight involvement of cranial arteries in GCA with a better inter-reader agreement in cranial segments than other segments.

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Section: Discussionmentioning

confidence: 72%

Diagnostic performance of digital PET with a dedicated head and neck protocol for the assessment of cranial arteries inflammation in Giant Cell Arteritis

Durand-Bailloud

Samson

Bertaut

et al. 2022

Preprint

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“…A joint procedural recommendation regarding performance of FDG-PET/CTA in large-vessel vasculitides was recently published, aiming at standardization of patient preparation, image acquisition, and interpretation. 2 Mural glucose uptake pattern is generally smooth, homogenous, and circumferential in GCA on PET/FDG imaging, 5 resembling HR-MRI findings. Additional use of CTA provides a high-resolution anatomic description and helps differentiate vasculitis from atherosclerosis.…”

Section: Gca Giant-cell Arteritis Hr-mrimentioning

confidence: 89%

“… Whole body 18 fluoro-deoxyglucose–positron emission tomography/CT angiography (FDG-PET/CTA). A and B , showing increased, grade 3 mural uptake (as reviewed by Nielsen et al, 5 graded against FDG liver uptake with grade 3 being considered consistent with vasculitis), depicted in pink, at the level of the subclavian ( A ) and common carotid arteries ( B ), bilaterally. Additionally, demonstration of megaesophagus with compression of the right lung ( A ).…”

Section: Case Reportmentioning

confidence: 99%

Minor Ischemic Stroke and a Smoldering Case of Giant-Cell Arteritis: A Case Report

Dimancea

Guidoux

Amarenco

2021

Stroke

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“…The high baseline arterial FDG uptake was associated with an increased incidence of subsequent relapse and vascular complications ( 15 , 16 ). In particular, a higher FDG uptake in the aorta than in the liver, as seen in the current case, carries a risk of aortic complications ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

A Long-term Persistent Vascular Fluorodeoxyglucose Uptake in a Patient with Large-vessel Vasculitis

Sakai

Kurosu

et al. 2022

Intern. Med.

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We herein report a case of large-vessel vasculitis in a 57-year-old woman who developed an intermittent fever and weight loss. While contrast-enhanced computed tomography was noncontributory, positron emission tomography-computed tomography (PET-CT) revealed the diffuse, intense uptake of fluorodeoxyglucose (FDG) in the aorta and its branches. Although she had no signs of relapse after successful oral corticosteroid therapy, PET-CT at 30 months revealed a persistent FDG uptake in the large vessels, which warranted regular follow-up imaging for vascular complications. In cases with an intense FDG uptake at the diagnosis, PET-CT follow-up after clinical remission may help predict the risk of relapse and vascular complications.

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18F-Fluorodeoxyglucose PET/Computed Tomography in the Diagnosis and Monitoring of Giant Cell Arteritis

Cited by 12 publications

References 81 publications

Diagnostic performance of digital PET with a dedicated head and neck protocol for the assessment of cranial arteries inflammation in Giant Cell Arteritis

Diagnostic performance of digital PET with a dedicated head and neck protocol for the assessment of cranial arteries inflammation in Giant Cell Arteritis

Minor Ischemic Stroke and a Smoldering Case of Giant-Cell Arteritis: A Case Report

A Long-term Persistent Vascular Fluorodeoxyglucose Uptake in a Patient with Large-vessel Vasculitis

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