18F-Fluorocholine PET/CT as a second line nuclear imaging technique before surgery for primary hyperparathyroidism

Impériale, Alessio; Taïeb, David; Hindié, Elif

doi:10.1007/s00259-017-3920-0

Cited by 21 publications

(13 citation statements)

References 34 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Potential disadvantages of PET/CT with 18 F-labeled choline analogues are higher costs, the uptake by inflammatory lymph nodes and thyroid nodules as a potential source of false-positive results [86], and local reimbursement and licensing issues.…”

Section: Commonly Used Choline Analogue In Clinical Practice Is ( N -[ ( 1 8 F ) F L U O R O M E T H Y L ] -2 -H Y D R O X Y -N Ndimethymentioning

confidence: 99%

“…In particular [ 18 F]FCH is very frequently taken up by mediastinal and/or axillary lymph nodes which are not suspicious for ectopic parathyroid glands. Uptake by one single cervical lymphadenopathy may constitute a problem for interpretation [86]. The analysis of the CT (or MRI) component yields a more precise anatomical localisation and may also increase specificity.…”

Section: Image Analysismentioning

confidence: 99%

See 1 more Smart Citation

The EANM practice guidelines for parathyroid imaging

Ovčariček

Giovanella

Gasset

et al. 2021

Eur J Nucl Med Mol Imaging

Self Cite

156

100

View full text Add to dashboard Cite

Introduction Nuclear medicine parathyroid imaging is important in the identification of hyperfunctioning parathyroid glands in primary hyperparathyroidism (pHPT), but it may be also valuable before surgical treatment in secondary hyperparathyroidism (sHPT). Parathyroid radionuclide imaging with scintigraphy or positron emission tomography (PET) is a highly sensitive procedure for the assessment of the presence and number of hyperfunctioning parathyroid glands, located either at typical sites or ectopically. The treatment of pHPT is mostly directed toward minimally invasive parathyroidectomy, especially in cases with a single adenoma. In experienced hands, successful surgery depends mainly on the exact preoperative localization of one or more hyperfunctioning parathyroid adenomas. Failure to preoperatively identify the hyperfunctioning parathyroid gland challenges minimally invasive parathyroidectomy and might require bilateral open neck exploration. Methods Over a decade has now passed since the European Association of Nuclear Medicine (EANM) issued the first edition of the guideline on parathyroid imaging, and a number of new insights and techniques have been developed since. The aim of the present document is to provide state-of-the-art guidelines for nuclear medicine physicians performing parathyroid scintigraphy, single-photon emission computed tomography/computed tomography (SPECT/CT), positron emission tomography/computed tomography (PET/CT), and positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with pHPT, as well as in those with sHPT. Conclusion These guidelines are written and authorized by the EANM to promote optimal parathyroid imaging. They will assist nuclear medicine physicians in the detection and correct localization of hyperfunctioning parathyroid lesions.

show abstract

Section: Commonly Used Choline Analogue In Clinical Practice Is ( N -[ ( 1 8 F ) F L U O R O M E T H Y L ] -2 -H Y D R O X Y -N Ndimethymentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

The EANM practice guidelines for parathyroid imaging

Ovčariček

Giovanella

Gasset

et al. 2021

Eur J Nucl Med Mol Imaging

Self Cite

156

100

View full text Add to dashboard Cite

show abstract

“…Surgical removal of the hyperfunctioning gland, (i.e., a parathyroidectomy) remains the only curative treatment for hyperparathyroidism (8). Preoperative localization of the hyperfunctioning gland is necessary for minimally invasive parathyroidectomy, which is associated with a reduced risk of complications and disability following surgery as compared to conventional bilateral cervical exploration (9).…”

Section: Introductionmentioning

confidence: 99%

Assessment and Comparison of ¹⁸F-Fluorocholine PET and ^99mTc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Analysis per lesion yielded a sensitivity of 18 F-fluorocholine of 91.3% and a PPV of 87.5% (49). Only 1 patient had MGD, fewer than expected in this setting (41,44,45), calling into question the sensitivity of 18 F-fluorocholine PET/CT for MGD (56). With regard to surgical outcomes, surgical failure occurred in 3 patients (13%) (49).…”

Section: Dual-tracer Subtraction Imaging In Patients With Negative Dual-phase Scintigraphy Resultsmentioning

confidence: 95%

Primary Hyperparathyroidism: Defining the Appropriate Preoperative Imaging Algorithm

et al. 2021

Self Cite

View full text Add to dashboard Cite

Primary hyperparathyroidism is a common and potentially debilitating endocrine disorder for which surgery is the only curative treatment. Preoperative imaging is always recommended, even in cases of conventional bilateral neck exploration, with a recognized role for 99m Tcsestamibi scintigraphy in depicting ectopic parathyroid lesions. Scintigraphy can also play a major role in guiding a targeted, minimally invasive parathyroidectomy. However, the ability to recognize multiple-gland disease (MGD) varies greatly depending on the imaging protocol used. Preoperative diagnosis of MGD is important to reduce the risks of conversion to bilateral surgery or failure. In this article we discuss imaging strategies before first surgery as well as in the case of repeat surgery for persistent or recurrent primary hyperparathyroidism. We describe a preferred algorithm and alternative options. Dualtracer 99m Tc-sestamibi/ 123 I subtraction scanning plus neck ultrasound is the preferred first-line option. This approach should improve MGD detection and patient selection for minimally invasive parathyroidectomy. Second-line imaging procedures in case of negative or discordant first-line imaging results are presented. High detection rates can be obtained with 18 F-fluorocholine PET/CT or with 4-dimensional CT. The risk of false-positive results should be kept in mind, however. Adding a contrast-enhanced arterial-phase CT acquisition to conventional 18 F-fluorocholine PET/CT can be a way to improve accuracy. We also briefly discuss other localization procedures, including 11 C-methionine PET/CT, MRI, ultrasound-guided fine-needle aspiration, and selective venous sampling for parathyroid hormone measurement.

show abstract

18F-Fluorocholine PET/CT as a second line nuclear imaging technique before surgery for primary hyperparathyroidism

Cited by 21 publications

References 34 publications

The EANM practice guidelines for parathyroid imaging

The EANM practice guidelines for parathyroid imaging

Assessment and Comparison of ¹⁸F-Fluorocholine PET and ^99mTc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis

Primary Hyperparathyroidism: Defining the Appropriate Preoperative Imaging Algorithm

Contact Info

Product

Resources

About

18F-Fluorocholine PET/CT as a second line nuclear imaging technique before surgery for primary hyperparathyroidism

Cited by 21 publications

References 34 publications

The EANM practice guidelines for parathyroid imaging

The EANM practice guidelines for parathyroid imaging

Assessment and Comparison of 18F-Fluorocholine PET and 99mTc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis

Primary Hyperparathyroidism: Defining the Appropriate Preoperative Imaging Algorithm

Contact Info

Product

Resources

About

Assessment and Comparison of ¹⁸F-Fluorocholine PET and ^99mTc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis