18F-Fluoride Positron Emission Tomography and Positron Emission Tomography/Computed Tomography

Even-Sapir, Einat; Mishani, Eyal; Flusser, Gideon; Metser, Ur

doi:10.1053/j.semnuclmed.2007.07.002

Cited by 174 publications

(150 citation statements)

References 36 publications

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“…The supplement of PET to CT information in this study seems to help either to support diagnosis of non-fusion or to confirm the diagnosis of complete fusion. As 18F-fluoride is taken up to form the mineral fluorapatite at the surface of bone crystals especially at sites of bone remodeling with high turnover [14], segments with increased uptake around cages compared to adjacent bony structures might be considered as non-fused and those with the same uptake as fused in a metabolic sense. Hence, 18F-fluoride PET/CT possibly has an impact on therapeutic decisions.…”

Section: Discussionmentioning

confidence: 99%

“…One clear limitation is the limited availability of 18F-fluoride and number of PET/ CT systems as well as the higher incremental costs of 18F-fluoride PET compared to planar and SPECT bone scintigraphy (BS). Nevertheless, 18F-fluoride PET/(CT) is an imaging modality which outperforms SPECT BS at least regarding spatial resolution and generates increasing interest with the worldwide shortage of molybdenum supply [12,14,32,33].…”

Section: Discussionmentioning

confidence: 99%

“…As a further advantage, 18F-fluoride allows imaging shortly (in our protocol about 30 min) after i.v. administration in contrast to 99mTc-MDP [13,14]. The current work presents a prospective study analyzing 18F-fluoride uptake around cages in patients after cervical and/or posterior lumbar intercorporal fusion.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of successful incorporation of cages after cervical or lumbar intercorporal fusion with [(18)F]fluoride positron-emission tomography/computed tomography

Fischer

Zweifel²,

Treyer

et al. 2010

Eur Spine J

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The purpose of this study is to assess the successful incorporation of cages in patients after cervical or lumbar intercorporal fusion with positron-emission tomography/computed tomography (PET/CT). Twenty patients (14 female and 6 male; mean age 58 years, age range 38-73 years) with 30 cervical (n = 13) or lumbar (n = 17) intercorporal fusions were prospectively enrolled in this study. Time interval between last intercorporal intervention and PET/CT ranged from 2 to 116 months (mean 63; median 77 months). IRB approval was obtained for all patients, and written informed consent was obtained from all patients. About 30 min prior to PET/CT scanning, 97-217 MBq (mean 161 MBq) 18F-fluoride were administered intravenously. Patients were imaged in supine position on a combined PET/CT system (Discovery RX/STE, 16/64 slice CT, GE Healthcare). 3D-PET emission data were acquired for 1.5 and 2 min/bed position, respectively, and reconstructed by a fully 3D iterative algorithm (VUE Point HD) using low-dose CT data for attenuation correction. A dedicated diagnostic thin-slice CT was optionally acquired covering the fused region. Areas of increased 18F-fluoride uptake around cages were determined by one double-board certified radiologist/ nuclear physician and one board certified radiologist in consensus. In 12/20 (60%) patients, increased 18F-fluoride uptake around cages was observed. Of the 30 intercorporal fusions, 15 (50%) showed increased 18F-fluoride uptake. Median time between intervention and PET/CT examination in cages with increased uptake was 37 months (2-116 months), median time between intervention and PET/CT examination in those cages without increased uptake was 91 months (19-112 months), p (Wilcoxon) = 0.01 (one-sided). 14/29 (48%) cages with a time interval [ 1 year between intervention and PET/CT scan showed an increased uptake. In conclusion, PET/CT frequently shows increased 18F-fluoride uptake in cervical and lumbar cages older than 1 year (up to almost 8 years in cervical cages and 10 years in lumbar cages) possibly indicating unsuccessful fusion due to increased stress/ microinstability.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Assessment of successful incorporation of cages after cervical or lumbar intercorporal fusion with [(18)F]fluoride positron-emission tomography/computed tomography

Fischer

Zweifel²,

Treyer

et al. 2010

Eur Spine J

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“…Furthermore, bone-seeking agents cannot depict bone marrow infiltration if there is no significant bone reaction. 18 F-NaF PET has recently been proposed as a highly accurate diagnostic tool (13), but uptake of 18 F-NaF reflects not only the presence of active tumor cells but also bone mineralization and remodeling. Therefore, the limitations of conventional bone scintigraphy also apply to 18 F-NaF PET.…”

mentioning

confidence: 99%

Bone Metastases in Patients with Neuroendocrine Tumor: ⁶⁸Ga-DOTA-Tyr³-Octreotide PET in Comparison to CT and Bone Scintigraphy

Putzer¹,

Gabriel²,

Henninger³

et al. 2009

J Nucl Med

189

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Somatostatin receptor scintigraphy is an accurate imaging modality for the diagnosis of neuroendocrine tumor. Because detection of distant metastases has a major impact on treatment, early diagnosis of metastatic spread is of great importance. So far, no standard procedure has become established for the early diagnosis of bone metastases from neuroendocrine tumor. We compared the diagnostic value of CT with that of the novel somatostatin analog 68 Ga-1,4,7,10-tetraazacyclododecane-N,N9,N$,N999-tetraacetic acid-D-Phe 1 -Tyr 3 -octreotide ( 68 Ga-DOTATOC) in the detection of such metastases. Methods: Fifty-one patients (22 women and 29 men; age range, 32-87 y) with histologically verified neuroendocrine tumor were included in this study. PET scans were fused with CT scans using a vacuum fixation device. 18 F-NaF or 99m Tc-dicarboxypropane diphosphonate bone scans or clinical follow-up served as the reference standard. Results: Twelve of the 51 patients had no evidence of bone metastases on any of the available imaging modalities, and 37 patients had 68 Ga-DOTATOC PET results true-positive for bone metastases. 68 Ga-DOTATOC PET results were true-negative for 12 patients, false-positive for one, and false-negative for another, resulting in a sensitivity of 97% and a specificity of 92%. 68 Ga-DOTATOC PET detected bone metastases at a significantly higher rate than did CT (P , 0.001). Furthermore, conventional bone scans confirmed the results of somatostatin receptor PET but did not reveal additional tumors in any patients. Conclusion: 68 Ga-DOTATOC PET is a reliable, novel method for the early detection of bone metastases in patients with neuroendocrine tumor. Our results show that CT and conventional bone scintigraphy are less accurate than 68 Ga-DOTATOC PET in the primary staging or restaging of neuroendocrine tumor.

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“…Estudos comparativos com a CO demonstram que a PET/ CT com FNa-F18 consegue detetar as metástases ósseas mais precocemente, 13 apresenta sensibilidade e acuidade superiores e é mais fiável para excluir a existência de metástases ósseas. [14][15][16] No nosso trabalho, limitados pela falta de um gold standard histológico para todas as lesões ósseas estudadas, não procurámos avaliar as característi-cas de sensibilidade, especificidade e acuidade diagnóstica das técnicas que comparámos.…”

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Superioridade da PET/CT com FNa-F18 na Deteção de Metástases Ósseas quando Comparada com Outros Métodos de Diagnóstico por Imagem

et al. 2017

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RESUMOIntrodução: A tomografia por emissão de positrões/tomografia computorizada -FNa-F18 vem sendo considerada como uma modalidade imagiológica com vantagens na pesquisa de metastização óssea. Comparámos a sua capacidade para deteção de metástases ósseas com a de outras técnicas imagiológicas. Material e Métodos: Avaliámos retrospetivamente 114 doentes que realizaram tomografia por emissão de positrões/tomografia computorizada -FNa-F18. Destes, 49 realizaram também cintigrafia óssea, 61 tomografia por emissão de positrões/tomografia computorizada -FDG-F18 e 10 tomografia por emissão de positrões/tomografia computorizada -FCH-F18. Identificámos a técnica que detetou um maior número de metástases ósseas. Comparámos ainda a tomografia por emissão de positrões com a componente tomografia computorizada da tomografia por emissão de positrões/tomografia computorizada -FNa-F18. Registámos as situações nas quais a tomografia por emissão de positrões/tomografia computorizada FNa-F18 e a cintigrafia óssea necessitaram de exames adicionais para esclarecimento complementar. Resultados: A tomografia por emissão de positrões/tomografia computorizada -FNa-F18 foi superior à cintigrafia óssea em 49% dos doentes (p < 0,001); foi superior à tomografia por emissão de positrões/tomografia computorizada -FDG-F18 em 59% dos doentes (p < 0,001) e foi superior à tomografia por emissão de positrões/tomografia computorizada -FCH-F18 em 40% dos doentes (p < 0,001). Nenhuma das técnicas imagiológicas avaliadas lhe foi superior. Na tomografia por emissão de positrões/tomografia computorizadaFNa-F18 a componente tomografia por emissão de positrões foi superior à tomografia computorizada em 35% dos casos (p < 0,001). Foi sugerida investigação complementar em apenas 3,5% dos doentes que realizaram tomografia por emissão de positrões/tomografia computorizada -FNa-F18 (45% para a cintigrafia óssea) (p < 0,001). Discussão: Em conformidade com o referido por outros autores, a nossa experiência confirma que a tomografia por emissão de positrões/tomografia computorizada -FNa-F18 tem excelente desempenho na deteção de metástases ósseas, sendo capaz de identificar lesões em mais doentes, e em maior número, quando comparada com outras técnicas imagiológicas. Conclusão: A tomografia por emissão de positrões/tomografia computorizada -FNa-F18 revelou superioridade na deteção de metástases ósseas comparativamente à cintigrafia óssea, à tomografia por emissão de positrões/tomografia computorizada -FDG-F18 e à tomografia por emissão de positrões/tomografia computorizada -FCH-F18. Palavras-chave: Cintigrafia; Neoplasias Ósseas/diagnóstico por imagem; Neoplasias Ósseas/secundário; Tomografia por Emissão de Positrões ABSTRACT Introduction: The 18F-NaF positron emission tomography/computed tomography is being considered as an excellent imaging modality for bone metastases detection. This ability was compared with other imaging techniques. Material and Methods:We retrospectively evaluated 114 patients who underwent 18F-NaF positron emission tomography/computed to...

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18F-Fluoride Positron Emission Tomography and Positron Emission Tomography/Computed Tomography

Cited by 174 publications

References 36 publications

Assessment of successful incorporation of cages after cervical or lumbar intercorporal fusion with [(18)F]fluoride positron-emission tomography/computed tomography

Assessment of successful incorporation of cages after cervical or lumbar intercorporal fusion with [(18)F]fluoride positron-emission tomography/computed tomography

Bone Metastases in Patients with Neuroendocrine Tumor: ⁶⁸Ga-DOTA-Tyr³-Octreotide PET in Comparison to CT and Bone Scintigraphy

Superioridade da PET/CT com FNa-F18 na Deteção de Metástases Ósseas quando Comparada com Outros Métodos de Diagnóstico por Imagem

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18F-Fluoride Positron Emission Tomography and Positron Emission Tomography/Computed Tomography

Cited by 174 publications

References 36 publications

Assessment of successful incorporation of cages after cervical or lumbar intercorporal fusion with [(18)F]fluoride positron-emission tomography/computed tomography

Assessment of successful incorporation of cages after cervical or lumbar intercorporal fusion with [(18)F]fluoride positron-emission tomography/computed tomography

Bone Metastases in Patients with Neuroendocrine Tumor: 68Ga-DOTA-Tyr3-Octreotide PET in Comparison to CT and Bone Scintigraphy

Superioridade da PET/CT com FNa-F18 na Deteção de Metástases Ósseas quando Comparada com Outros Métodos de Diagnóstico por Imagem

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Product

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Bone Metastases in Patients with Neuroendocrine Tumor: ⁶⁸Ga-DOTA-Tyr³-Octreotide PET in Comparison to CT and Bone Scintigraphy