18F-FDG PET/TC como herramienta para la valoración de respuesta terapéutica en un paciente con sarcoidosis sistémica

Losada, María Mangas; Villegas, A. Cabrera; Megías, I. García; Robles, Leonardo Romero; Chollet, Xavier Boulvard; Lasanta, Rafael Ramírez

doi:10.1016/j.remn.2021.06.007

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“…Sarcoidosis is a multisystem non-caseating granulomatous autoimmune disorder of unknown etiology ( 1 ). Although fluorine 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is not included in the standard workup for sarcoidosis, it has been proven to be valuable in guiding diagnosis and management ( 2 - 5 ). 18F-FDG PET/CT enables detailed functional and anatomic evaluation of the entire body that is not possible with other imaging modalities.…”

Section: Introductionmentioning

confidence: 99%

Value of 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the differential diagnosis of sarcoidosis and lung cancer with lymph node metastasis: a retrospective study

Chen¹,

Xu²,

Chrysikos³

et al. 2022

Transl Lung Cancer Res

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Background: Fluorine 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has been proven to be valuable in guiding the diagnosis and management of sarcoidosis.However, its differential value for sarcoidosis is unclear. The objective of this study was to explore the value of 18F-FDG PET/CT in differentiation sarcoidosis from lung cancer with lymph node metastasis.Methods: A total of 361 consecutively diagnosed sarcoidosis patients and 1,944 consecutively diagnosed lung cancer patients at Shanghai Pulmonary Hospital were retrospectively reviewed. Among them, 85 patients diagnosed with sarcoidosis and 94 lung cancer patients with lymph node metastasis were enrolled.Demographic data and 18F-FDG PET/CT parameters were analyzed by the chi-square test or independent sample Student's t-test. Receiver operating characteristic (ROC) curves were generated to identify cut-off values. Multivariate logistic regression was performed to identify independent predictors of sarcoidosis on 18F-FDG PET/CT, and those with P<0.1 were included in a regression model using the forward log rank (LR) method to generate a ROC curve. Results:The ratio of extrapulmonary lymph node involvement in sarcoidosis patients was significantly higher than that in lung cancer patients (64.7% vs. 29.8%, P<0.001). After adjusting for gender and age, extrapulmonary lymph node involvement [odds ratio (OR): 3.160; 95% confidence interval (CI): 1.105-9.035], maximum standardized uptake value (SUVmax) of mediastinum/hilar lymph nodes >13.86

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Section: Introductionmentioning

confidence: 99%