18F-FDG PET/MRI in endometrial cancer: systematic review and meta-analysis

Bezzi, Carolina; Zambella, Enrica; Ghezzo, Samuele; Fallanca, Federico; Gajate, Ana Maria Samanes; Franchini, Annalisa; Ironi, Gabriele; Bergamini, Alice; Monaco, Lavinia; Evangelista, Laura; Mangili, Giorgia; Cobelli, Francesco De; Mapelli, Paola

doi:10.1007/s40336-021-00463-8

Cited by 4 publications

(5 citation statements)

References 40 publications

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“…[F-18]-FDG PET/MRI is a valid imaging technique in patients with endometrial cancer, both in staging and restaging as an alternative diagnostic strategy to conventional imaging modalities, also considering the limited radiation exposure [509][510][511], whereas integrated PET/MRI successfully assesses the lymph node metastasis and myometrial invasion in patients with endometrial cancer [512,513]. MRI-guided intensity-modulated radiation therapy has been used for locally recurrent endometrial cancer after resection [514].…”

Section: Endometrial Cancermentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer, although some other studies indicate no relationship. In this review, after an introduction on the MF definition and a description of natural/anthropogenic sources, the epidemiology of residential/domestic and occupational exposure to MFs and cancer is reviewed, with reference to leukemia, brain, and breast cancer. The in vivo and in vitro effects of MFs on cancer are reviewed considering both human and animal cells, with particular reference to the involvement of reactive oxygen species (ROS). MF application on cancer diagnostic and therapy (theranostic) are also reviewed by describing the use of different magnetic resonance imaging (MRI) applications for the detection of several cancers. Finally, the use of magnetic nanoparticles is described in terms of treatment of cancer by nanomedical applications for the precise delivery of anticancer drugs, nanosurgery by magnetomechanic methods, and selective killing of cancer cells by magnetic hyperthermia. The supplementary tables provide quantitative data and methodologies in epidemiological and cell biology studies. Although scientists do not generally agree that there is a cause-effect relationship between exposure to MF and cancer, MFs might not be the direct cause of cancer but may contribute to produce ROS and generate oxidative stress, which could trigger or enhance the expression of oncogenes.

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Section: Endometrial Cancermentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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“…Patients' preparation, radiotracer injection, and acquisition protocol were performed as previously described [22]. In relation to the retrospective design of the study, different tomographs were used: (1) a fully hybrid 3T PET/MRI system (SIGNA PET/MRI; General Electric Healthcare, Waukesha, WI, USA), (2) a Discovery ST (General Electric Healthcare), (3) a Discovery STE (General Electric Healthcare), (4) a Gemini-GXL (Philips Medical Systems, Eindhoven, The Netherlands), and (5) a Discovery 690 (General Electric Healthcare).…”

Section: F-fdg Pet Protocolsmentioning

confidence: 99%

“…Conventional imaging modalities, including transvaginal ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT), provide detailed morphological information on EC, with only limited assessment of functional characteristics [22,23]. 18 Ffluoro-deoxyglucose ( 18 F-FDG) positron emission tomography (PET) has a well-established role in the preoperative staging of EC patients, and it is included in the clinical guidelines on EC management [24,25].…”

Section: Introductionmentioning

confidence: 99%

Role of Machine Learning (ML)-Based Classification Using Conventional 18F-FDG PET Parameters in Predicting Postsurgical Features of Endometrial Cancer Aggressiveness

Bezzi

Bergamini

Mathoux

et al. 2023

Cancers

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Purpose: to investigate the preoperative role of ML-based classification using conventional 18F-FDG PET parameters and clinical data in predicting features of EC aggressiveness. Methods: retrospective study, including 123 EC patients who underwent 18F-FDG PET (20092021) for preoperative staging. Maximum standardized uptake value (SUVmax), SUVmean, metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were computed on the primary tumour. Age and BMI were collected. Histotype, myometrial invasion (MI), risk group, lymph-nodal involvement (LN), and p53 expression were retrieved from histology. The population was split into a train and a validation set (80–20%). The train set was used to select relevant parameters (Mann-Whitney U test; ROC analysis) and implement ML models, while the validation set was used to test prediction abilities. Results: on the validation set, the best accuracies obtained with individual parameters and ML were: 61% (TLG) and 87% (ML) for MI; 71% (SUVmax) and 79% (ML) for risk groups; 72% (TLG) and 83% (ML) for LN; 45% (SUVmax; SUVmean) and 73% (ML) for p53 expression. Conclusions: ML-based classification using conventional 18F-FDG PET parameters and clinical data demonstrated ability to characterize the investigated features of EC aggressiveness, providing a non-invasive way to support preoperative stratification of EC patients.

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“…Bezzi and colleagues conducted a systematic review and meta-analysis on the use of hybrid FDG PET/MR imaging for EC staging/re-staging, analyzing eleven articles. Their results indicated that FDG PET/MRI is a valid imaging technique for EC patients, both for staging and re-staging, while also potentially reducing radiation exposure [16]. However, the limited availability in the literature of studies on FDG PET/MRI underscores the need for more prospective trials with larger and more homogeneous cohorts.…”

Section: Staging or Diagnosis Of Primary Ecmentioning

confidence: 99%

“…For the diagnosis of LNM, these values were 0.72, 0.94, 10.9, 0.36, 39.7, and 0.94, respectively [22]. In a 2021 study by Bezzi et al, PET/MRI was found to offer an opportunity to distinguish post-treatment changes from local recurrence and to detect small and indeterminate lymph node metastases in patients with recurrent EC, showing superior performance compared to other imaging modalities [16]. Based on the literature review, it can be concluded that FDG PET/CT exhibits appropriate diagnostic performance for the preoperative detection of LNM in EC patients [22].…”

Section: Detection or Prediction Of Metastases Of Ecmentioning

confidence: 99%

18F-FDG PET/MRI and 18F-FDG PET/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature

Allahqoli,

Hakimi,

Laganà

et al. 2023

J. Imaging

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Objective: Positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro- D-glucose integrated with computed tomography (18F-FDG PET/CT) or magnetic resonance imaging (18F-FDG PET/MRI) has emerged as a promising tool for managing various types of cancer. This review study was conducted to investigate the role of 18F- FDG PET/CT and FDG PET/MRI in the management of gynecological malignancies. Search strategy: We searched for relevant articles in the three databases PubMed/MEDLINE, Scopus, and Web of Science. Selection criteria: All studies reporting data on the FDG PET/CT and FDG PET MRI in the management of gynecological cancer, performed anywhere in the world and published exclusively in the English language, were included in the present study. Data collection and analysis: We used the EndNote software (EndNote X8.1, Thomson Reuters) to list the studies and screen them on the basis of the inclusion criteria. Data, including first author, publication year, sample size, clinical application, imaging type, and main result, were extracted and tabulated in Excel. The sensitivity, specificity, and diagnostic accuracy of the modalities were extracted and summarized. Main results: After screening 988 records, 166 studies published between 2004 and 2022 were included, covering various methodologies. Studies were divided into the following five categories: the role of FDG PET/CT and FDG-PET/MRI in the management of: (a) endometrial cancer (n = 30); (b) ovarian cancer (n = 60); (c) cervical cancer (n = 50); (d) vulvar and vagina cancers (n = 12); and (e) gynecological cancers (n = 14). Conclusions: FDG PET/CT and FDG PET/MRI have demonstrated potential as non-invasive imaging tools for enhancing the management of gynecological malignancies. Nevertheless, certain associated challenges warrant attention.

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18F-FDG PET/MRI in endometrial cancer: systematic review and meta-analysis

Cited by 4 publications

References 40 publications

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Role of Machine Learning (ML)-Based Classification Using Conventional 18F-FDG PET Parameters in Predicting Postsurgical Features of Endometrial Cancer Aggressiveness

18F-FDG PET/MRI and 18F-FDG PET/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature

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