18F-FDG PET/MR in an Atypical Pediatric Solid Pseudopapillary Pancreatic Tumor

Cavaliere, Annachiara; Giraudo, Chiara; Zuliani, Monica; Cecchin, Diego; Quaia, Emilio

doi:10.1097/rlu.0000000000002671

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…It combines the benefits of both PET and MRI, and provides detailed anatomical and functional information in a single imaging session. Similar to PET/CT, PET/MRI can also show focal FDG uptake, allowing for identification and localization of active tumor regions[ 58 ]. Both aid in staging, prognostication, and early detection of recurrence, and assist in treatment planning[ 59 ].…”

Section: Imaging Techniques For Detection and Characterizationmentioning

confidence: 99%

Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Xu,

Fu,

Yang

2024

World J Gastrointest Oncol

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Solid pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasm predominantly observed in young females. Pathologically, CTNNB1 mutations, β-catenin nuclear accumulation, and subsequent Wnt-signaling pathway activation are the leading molecular features. Accurate preoperative diagnosis often relies on imaging techniques and endoscopic biopsies. Surgical resection remains the mainstay treatment. Risk models, such as the Fudan Prognostic Index, show promise as predictive tools for assessing the prognosis of SPTP. Establishing three types of metachronous liver metastasis can be beneficial in tailoring individualized treatment and follow-up strategies. Despite advancements, challenges persist in understanding its etiology, establishing standardized treatments for unresectable or metastatic diseases, and developing a widely recognized grading system. This comprehensive review aims to elucidate the enigma by consolidating current knowledge on the epidemiology, clinical presentation, pathology, molecular characteristics, diagnostic methods, treatment options, and prognostic factors.

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Section: Imaging Techniques For Detection and Characterizationmentioning

confidence: 99%

Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Xu,

Fu,

Yang

2024

World J Gastrointest Oncol

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“…Similar to PET-CT, PET-MR combines the advantages of PET and MRI, displaying an elevated definition for SPNs. Despite being costly to the majority of patients, PET-MR can be employed to confirm identification before invasive examination [ 40 ] or to make a differential diagnosis [ 41 ].…”

Section: Identification and Assessment Of Spn Malignancymentioning

confidence: 99%

Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management

Lu,

Chen,

Zhang

2024

Discov Onc

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Solid pseudopapillary neoplasms (SPN) of the pancreas are presently recognized as low-grade malignant tumors that are frequently observed in young females. This tumor has a low incidence and is associated with an excellent prognosis following surgical resection. Typical SPNs primarily affect the pancreas and tend to have moderate or asymptomatic manifestations. Based on retrospective research, it is anticipated that patients with SPN can achieve disease-free survival, even in cases when metastasis is detected during inspection. However, the incidence of malignant SPN has been consistently underestimated, as evidenced by recent research findings. Malignancy of SPN primarily encompasses invasion and infiltration, metastasis, and recurrence after R0 resection. Imaging technologies such as Ultrasound, Computed Tomography, Magnetic Resonance Imaging, and Position Emission Tomography are capable of preliminarily identifying malignant SPN, which is primarily based on its invasive clinical features. Research on risk factors of malignant SPN revealed that larger tumor size, Ki-67 index, and several other parameters had significant correlations with invasive tumor behavior. Pathologic features of malignant SPNs overlay other pancreatic tumors, nevertheless they can provide valuable assistance in the process of diagnosis. Several confirmed specific pathologic biomarkers are related to its cellular origin, characteristic gene mutation, and cell proliferation. Considering the invasiveness of malignant SPN, it is imperative to enhance the comprehensiveness of its therapy. Tumor resection remains a suggested course of action in line with typical SPN, and additional lymph node dissection is seen as reasonable. Compared to benign SPNs, malignant SPNs have worse prognosis, underscoring the necessity of early identification and treatment in comprehensive medical centers to get improved clinical outcomes.

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