18F-FDG PET-MR enterography in predicting histological active disease using the Nancy index in ulcerative colitis: a randomized controlled trial

Diagnostic Performance of Simultaneous [18F]-FDG PET/MR for Assessing Endoscopically Active Inflammation in Patients with Ulcerative Colitis: A Prospective Study

“…This result was supported by a former study with 15 UC patients utilizing PET/CT, which demonstrated significantly increased FDG-uptake (SUVmaxQuot between 1 and 3) in segments with endoscopically severe inflammation (spontaneous bleeding, severe friability and/or ulcerations) [17]. In addition, SUVmaxQuot is a reliable quantitative parameter with excellent inter-observer concordant measurement [13].…”

“…After purgation, no inflammatory cell infiltrate such as neutrophils were present in bowel segments under histologic remission. Therefore, the bowel preparation might result in false-positive interpretation of PET [13]. As demonstrated in our study, such misinterpretation of PET could be avoided by combined reading of PET and MR.…”

“…After purgation, no inflammatory cell infiltrate such as neutrophils were present in bowel segments under histologic remission. Therefore, the bowel preparation might result in false-positive interpretation of PET [13]. As demonstrated in our study, such misinterpretation of PET could be avoided by combined reading of PET and MR. Other than CD, in which wall thickness was considered the most important diagnostic parameter for inflammation detection [8], inflamed colonic segments in UC showed only mild wall thickening.…”

“…Hybrid biomarkers comprised of PET and MR parameters facilitated higher diagnostic values than each modality alone not only in assessing disease activity but also in differentiating fibrotic strictures from mixed or inflammatory ones in Crohn's disease [11,12]. Previously, in a randomized controlled trial (RCT), we have investigated the diagnostic accuracies of [ 18 F]-FDG PET/MR in predicting histologically active inflammation in 50 patients with UC [13]. Our results revealed the strong association between the change of metabolic condition of bowel wall and the degree of neutrophil infiltrate.…”

Re: 18F-FDG PET-MR enterography in predicting histological active disease using the Nancy index in ulcerative colitis: a randomized controlled trial

“…We read with interest the article by Li et al " 18 F-FDG PET-MR enterography in predicting histological active disease using the Nancy index in ulcerative colitis: a randomized controlled trial. Eur J Nucl Med Mol Imaging" [1]. The authors describe that among the parameters of 18 F-FDG PET-MR enterography, the maximum standardized uptake value (SUV max ) ratio of bowel segment to the liver has the highest specificity and diagnostic accuracy to predict histologically active inflammation in ulcerative colitis (UC).…”