18F-FDG PET for the diagnosis and assessment of treatment response of autoimmune limbic encephalitis

Carabaño, D. Tamayo; Báñez, I. Acevedo; Ramírez, J.A. Lojo; Morillo, José; Solís, David García; García, J.M. Jiménez-Hoyuela

doi:10.1016/j.remnie.2022.09.003

Cited by 1 publication

(5 citation statements)

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“…Abnormal FDG‐PET brain scans have been reported in anti‐NMDAR encephalitis patients but metabolic patterns have been inconsistent across different regions. 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 25 , 27 , 28 , 29 , 30 In this study, we investigated the application of FDG‐PET during different stages of anti‐NMDAR encephalitis disease progression. First, notably (but unsurprisingly) we found that consistent with other diseases, the brain‐glucose metabolic patterns changed during different stages ( p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Abnormal FDG‐PET brain scans have been reported in anti‐NMDAR encephalitis patients but metabolic patterns have been inconsistent across different regions 4–20,25,27–30 . In this study, we investigated the application of FDG‐PET during different stages of anti‐NMDAR encephalitis disease progression.…”

Section: Discussionmentioning

confidence: 99%

“…FDG‐PET and MRI examinations are important and recommended for auxiliary diagnosis of NMDAR‐AE. 1 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 Previous studies showed that FDG‐PET provided earlier detection and had a higher diagnostic sensitivity rate than MRI. 4 , 5 , 6 , 13 , 14 , 15 , 16 , 17 However, there is no consensus on the abnormal patterns of FDG‐PET, including hypo or hypermetabolism of the frontal, temporal, and occipital lobes, and the basal ganglia and cerebellum.…”

Section: Introductionmentioning

confidence: 99%

“… 4 , 5 , 6 , 13 , 14 , 15 , 16 , 17 However, there is no consensus on the abnormal patterns of FDG‐PET, including hypo or hypermetabolism of the frontal, temporal, and occipital lobes, and the basal ganglia and cerebellum. To the best of our knowledge, most studies have been case reports or included fewer than five patients per group with subgroup analysis, 4 , 5 , 6 , 7 , 8 , 9 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 causing confusion regarding the accurate diagnosis of the disease. Electroencephalography (EEG) is useful for auxiliary diagnosis and evaluation of prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…FDG‐PET and MRI examinations are important and recommended for auxiliary diagnosis of NMDAR‐AE 1,3–12 . Previous studies showed that FDG‐PET provided earlier detection and had a higher diagnostic sensitivity rate than MRI 4–6,13–17 .…”

Section: Introductionmentioning

confidence: 99%

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Hypometabolism of the left middle/medial frontal lobe onFDG‐PETin anti–NMDAreceptor encephalitis: Comparison withMRIandEEGfindings

et al. 2023

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Objectives To investigate changes in brain‐glucose metabolism in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis, and compare results with MRI and electroencephalography (EEG) findings at different disease stages. Methods The clinical data of 18 patients (median age, 35 years; 11 men) were retrospectively collected. Patients were divided into groups based on the time of symptom onset to examination, (≤1 month, >1 but ≤3 months, >3 months). Two‐sample t ‐test results were compared with age and sex‐paired healthy controls using statistical parametric mapping and verified using a NeuroQ software normal database with a discriminating z‐score of 2. Results Abnormal patterns on FDG‐PET differed over time ( T = 3.21–8.74, Z = 2.68–4.23, p < 0.005). Regional analysis showed hypometabolic left middle or medial frontal cortex in 4/5, 5/7, and 5/6 patients, respectively. Time‐subgroup analysis revealed hypermetabolic supertemporal cortex in 4/5, 5/7, and 2/6, patients, respectively. MRI and EEG abnormalities in any region and stage occurred in 10/18 and 10/16 patients, respectively. MRI and EEG time‐subgroup analysis showed abnormalities in 5/9, 4/5, and 1/4, and 1/3, 6/7, and 3/6 patients, respectively. Abnormal temporal lobes were detected most frequently in MRI analyses and occurred in 3/10 patients. Conclusions Decreased left middle/medial frontal metabolism could be common to all stages. Metabolism in other regions, MRI, and EEG results were associated with the progression of anti‐NMDAR encephalitis. The sensitivity rate of FDG‐PET was superior to that of MRI and EEG.

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