18F-FDG PET/CT “superscan” in a patient with immunoblastic lymphoma

Case report: 18F-FDG PET/CT skeletal superscan-like in an adult patient with acute lymphoblastic leukemia

“…This feature “looks too good” due to the diffuse and symmetric skeletal uptake, similar to the appearance of a bone scan. To date, diffuse tracer uptake in the skeleton/bone marrow as a skeletal superscan pattern on 18 F-FDG PET/CT has been previously reported in hematological diseases (including two cases of multiple myeloma ( 12 , 13 ), two cases of lymphoma and two cases of acute lymphoblastic leukemia ( 6 , 14 – 16 ), and one case of hemophagocytic lymphohistiocytosis) ( 17 ), nine cases of solid tumors with extensive bone metastasis ( 11 , 18 – 25 ), and metabolic diseases with three cases of hyperparathyroidism and one case of renal osteodystrophy ( 26 – 29 ). By reviewing all the medical images of the reports, the hematological diseases revealed greater homogeneous radiotracer uptake in the skeleton, as in our case, and the metabolic diseases all had a specific skull and mandible intense uptake pattern.…”

Metabolic Superscan on 18F-FDG PET/CT in a Patient With Secondary Hyperparathyroidism

“…Parathyroidectomy of both lesions at inferior pole of both thyroid lobes demonstrated parathyroid hyperplasia. Superscan in FDG PET/CT usually involved metastatic disease of the bone and has been reported in poorly differentiated renal adenocarcinoma, 1 lymphoma, 2,3 lung cancer, 4,5 and breast and gastric cancer 6 . Superscan has also been reported in nonskeletal metastasis such as liver 7,8 and peritoneum 9 .…”

Diffuse skeletal uptake on 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography scan in a patient with acute lymphoblastic leukemia: A typical superscan pattern resembling naf positron emission tomography scan

“…[123] Later, the application of this term is generalized to similar features in other scans or any dominant uptake limited to a specific organ, for example, liver,[45] suppressing uptake elsewhere, although some misuses have been occurred. Diffuse 18 FDG uptake in the skeleton and bone marrow as superscan pattern on PET scan has been reported in multiple malignant disorders, including lymphoma and leukemia,[67] multiple myeloma,[8] and metastasis like prostate cancer[910] as well as other hematologic conditions, for example, following administration of granulocyte colony-stimulating factor. [11] This finding is also observed in metabolic disorders such as renal osteodystrophy[12] and parathyroid carcinoma.…”