18F-FDG PET/CT or PET Role in MALT Lymphoma: An Open Issue not Yet Solved—A Critical Review

Albano, Domenico; Durmo, Rexhep; Treglia, Giorgio; Giubbini, Raffaele; Bertagna, Francesco

doi:10.1016/j.clml.2019.10.006

Cited by 38 publications

(29 citation statements)

References 50 publications

(210 reference statements)

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“…The applicability of FDG-PET/CT in MALT lymphomas is still controversial due to variable FDG avidity at different MALT locations. Pulmonary and head/neck MALT lymphomas seem to be most FDG avid, and FDG-PET/CT shows higher sensitivities at these regions [ 116 , 117 ]. Since pSS-associated MALT lymphomas frequently develop in the salivary glands and/or lungs, there may be a role for this technique in the detection of lymphomas associated with pSS [ 113 , 118 , 119 ] ( Figure 3 ).…”

Section: Nuclear Medicine Techniquesmentioning

confidence: 99%

Imaging in Primary Sjögren’s Syndrome

Ginkel

Glaudemans

Vegt

et al. 2020

JCM

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Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dysfunction and lymphocytic infiltration of the salivary and lacrimal glands. Besides the characteristic sicca complaints, pSS patients can present a spectrum of signs and symptoms, which challenges the diagnostic process. Various imaging techniques can be used to assist in the diagnostic work-up and follow-up of pSS patients. Developments in imaging techniques provide new opportunities and perspectives. In this descriptive review, we discuss imaging techniques that are used in pSS with a focus on the salivary glands. The emphasis is on the contribution of these techniques to the diagnosis of pSS, their potential in assessing disease activity and disease progression in pSS, and their contribution to diagnosing and staging of pSS-associated lymphomas. Imaging findings of the salivary glands will be linked to histopathological changes in the salivary glands of pSS patients.

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Section: Nuclear Medicine Techniquesmentioning

confidence: 99%

Imaging in Primary Sjögren’s Syndrome

Ginkel

Glaudemans

Vegt

et al. 2020

JCM

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“…16 Although combined CT and positron emission tomography (CT/PET) is actually the gold standard for staging purpose in case of primary cutaneous follicle centre lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type, its introduction as a routine staging test in case of PC-MZL is still debated. 44 Bone marrow biopsy is not mandatory, but it may be useful in the case of single or multiple cell line cytopenia. 22 PC-MZL staging yet requires a careful history and clinical examination and laboratory tests such as: blood count, LDH, Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), beta-2 microglobulin, Serum Protein Electrophoresis (SPE), HIV antibodies, HBV antibodies, AST, ALT, creatinine, amylase, lipase, bilirubin, HCV Antibodies.…”

Section: Patient Managementmentioning

confidence: 99%

Dermatological Considerations in the Diagnosis and Treatment of Marginal Zone Lymphomas

Ronchi

Sica

Vitiello

et al. 2021

CCID

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Primary cutaneous marginal zone lymphoma (PC-MZL) is a B-cell lymphoma arising in the skin. Although it is a rare disease, PC-MZL accounts for 20–40% of all primary cutaneous B-cell lymphoma in Western Countries. The aetiology and the pathogenesis of PC-MZL are poorly understood, as it generally lacks the chromosomal translocations most typically present in marginal zone lymphomas of other sites. The diagnosis of PC-MZL may be challenging, due to the rarity of the disease, and needs the competence of different professional figures, including the dermatologist and the pathologist. Furthermore, the management of the patient after the diagnosis is complex and involves the dermatologist, the haematologist, the surgeon, the radiotherapist and the radiologist. The aim of this review is to describe the clinical and histological findings for the diagnosis of PC-MZL, and the state of art for the management of the patient.

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“…The staging of marginal zone lymphoma is a challenge with [ 18 F]FDG PET/CT, because marginal zone lymphoma usually does not present with elevated glycolysis and may had heterogeneous metabolic behavior [20,21]. Stollberg S. and the colleagues found that CXCR4 expression was present at a high intensity in 92% of the cases [22].…”

Section: Marginal Zone Lymphomamentioning

confidence: 99%

Preliminary evidence of imaging of chemokine receptor-4-targeted PET/CT with [68Ga]pentixafor in non-Hodgkin lymphoma: comparison to [18F]FDG

et al. 2020

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Background: In order to study the CXCR4 expression with [ 68 Ga]pentixafor PET in different types of non-Hodgkin lymphoma, we performed a retrospective study to describe the [ 68 Ga]pentixafor PET/CT imaging in a spectrum of lymphomas and to compare it with [ 18 F]FDG PET/CT. Results: Twenty-seven patients with newly diagnosed non-Hodgkin lymphoma were recruited retrospectively. [ 68 Ga]pentixafor PET showed increased radioactivity in lymphoplasmacytic lymphoma (n = 8), marginal zone lymphoma (n = 4), diffuse large B cell lymphoma (n = 3), follicular lymphoma (n = 2), mantle cell lymphoma (n = 1), unclassified indolent B cell lymphoma (n = 3), and enteropathy associated T cell lymphoma (n = 3). However, peripheral T cell lymphoma, not otherwise specified (n = 1), and NK/T cell lymphoma (n = 2) were not avid for [ 68 Ga]pentixafor. In comparison to [ 18 F]FDG PET, [ 68 Ga]pentixafor PET demonstrated more extensive disease and higher radioactivity in lymphoplasmacytic lymphoma and marginal zone lymphoma. Conclusion: CXCR4 expression varies in different types of non-Hodgkin lymphoma. Overexpression of CXCR4 was detected with [ 68 Ga]pentixafor PET/CT in lymphoplasmacytic lymphoma, marginal zone lymphoma, diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma, unclassified indolent B cell lymphoma, and enteropathy associated T cell lymphoma. The uptake of [ 68 Ga]pentixafor was higher than [ 18 F]FDG in lymphoplasmacytic lymphoma and marginal zone lymphoma.

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18F-FDG PET/CT or PET Role in MALT Lymphoma: An Open Issue not Yet Solved—A Critical Review

Cited by 38 publications

References 50 publications

Imaging in Primary Sjögren’s Syndrome

Imaging in Primary Sjögren’s Syndrome

Dermatological Considerations in the Diagnosis and Treatment of Marginal Zone Lymphomas

Preliminary evidence of imaging of chemokine receptor-4-targeted PET/CT with [68Ga]pentixafor in non-Hodgkin lymphoma: comparison to [18F]FDG

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