18F-FDG PET/CT in suspected recurrences of epithelial malignant pleural mesothelioma in asbestos-fibers-exposed patients (comparison to standard diagnostic follow-up)

Asabella, Artor Niccoli; Notaristefano, Antonio; Rubini, D.; Altini, Corinna; Ferrari, Cristina; Merenda, Nunzio; Fanelli, Margherita; Rubini, Giuseppe

doi:10.1016/j.clinimag.2013.06.009

Cited by 25 publications

(17 citation statements)

References 21 publications

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“…There are also additional findings of the specific parameters that contribute more towards survival (CT, RECIST (response evaluation criteria in solid tumors) and PET, TLG/PETvol (tumor lesion glycolysis/tumor volume) more than SUV max ) [41]. In agreement with that, another analysis by Niccoli-Asabella et al [42] concluded that FDG PET/CT is useful to monitor the follow-up and assess the metabolic response to chemo and radiotherapy. This study compared PET/CT with standard diagnostic follow-up CECT (contrast-enhanced computed tomography).…”

Section: Prospect Of Pet/ct In Therapeutic Assessmentsupporting

confidence: 58%

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Value of FDG PET/CT in the Management of Mesothelioma

Hanifa¹,

Ardekani²,

Subramaniam³

2016

JPP

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Abstract:The aim of this study is to compare and discuss the efficacy of FDG PET/CT (fludeoxyglucose positron emission tomography/computated tomography) in the diagnosis, staging, prognosis, pre-therapeutic planning, therapeutic assessment and detecting recurrence of mesothelioma. Following method has been used: (1) Search setting on PubMed (by priority): meta-analysis, randomized controlled trial, other study types; (2) The key words: "FDG PET/CT", "mesothelioma", "diagnosis", "staging", "prognosis", "therapeutic", "assessment" and "recurrences"; (3) Review the literature that discusses the imaging modalities in the management of mesothelioma; (4) Create an evidence table; (5) Compare and discuss the different modalities and their sensitivity and specificity in managing mesothelioma; (6) Construct the passage reviewing the articles chosen. There is evidence that suggests that FDG PET/CT is superior to most other modalities in the diagnosis, staging, prognosis, pre-therapeutic planning, therapeutic assessment and detecting recurrence of mesothelioma. There are some close contenders like PET scan by itself as a modality to detect mesothelioma. However, due to the lack of anatomical presentation, there were many occurrences of misdiagnosis. FDG PET/CT, which superimposes functional imaging over the anatomical mapping, yields a more accurate presentation of mesothelioma. The nature of this hybrid imaging enables diagnosis and management to be carried-out in a minimally invasive manner. PET/CT to a great extent has tranformed the way we diagnose neoplastic occurences heretofore. By amalgamating anatomic localization to functional imaging, this hybrid modality yields valuable information that was remotely attainable before. Although there are a few flaws to PET/CT that have been discussed in some studies, there is an apparent potential to this modality that is waiting to be uncovered. Evidently, PET/CT is highly effective in differentiating benign and malignant pleural lesion. Likewise, it is substantially useful in the management of mesothelioma particularly in the diagnosis, staging, prognosis, treatment, monitoring and detecting recurrences. With PET/CT having such adequacy in managing mesothelioma, it is imperative to acknowledge and further investigate this modality as a central tool in the management of the latter for the exclusive benefit of the patient.

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Section: Prospect Of Pet/ct In Therapeutic Assessmentsupporting

confidence: 58%

“…This study compared PET/CT with standard diagnostic follow-up CECT (contrast-enhanced computed tomography). While the sensitivity was high in both PET/CT (100%) and CECT (96.2%), the specificity was higher in PET/CT (100%) compared to CECT (20%) [42].…”

Section: Prospect Of Pet/ct In Therapeutic Assessmentmentioning

confidence: 99%

Value of FDG PET/CT in the Management of Mesothelioma

Hanifa¹,

Ardekani²,

Subramaniam³

2016

JPP

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“…Basu et al (20) proposed that the use of 18F FDG uptake in results estimation in the differentiation of benign lesions from MPM, the evolution of responses to therapy, and the analysis of post-treatment recurrence are crucial MPM research areas. It has been shown that 18F FDG PET-CT has high precision and that it is good at specifying the local extension of the disease, lymph node involvement, and metastasis (21).…”

Section: Discussionmentioning

confidence: 99%

Staged Surgical Treatment in an Infant with Huge Aortopulmonary Window Presenting with Severe Pulmonary Hypertension and Recurrent Pulmonary Infection

Özyurt¹,

Tunçay²,

Tekerek³

et al. 2015

Erciyes Med J

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Objective: The aim of this study was to evaluate the role of diffusion-weighted magnetic resonance imaging (dMRI) in differentiating between diffuse malignant and benign pleural thickening in asbestos-related pleural diseases.Materials and Methods: Sixty-two patients were included in the study. Thirty-two had a benign form and 30 had malignant pleural mesothelioma (MPM). The patient files and records belonging to those who underwent dMRI on a 1.5 T MR system between May 2014 and January 2016 in our clinic were examined retrospectively. The dMRI was performed with 0, 500, and 1000 mm 2 /s b-values. The apparent diffusion coefficient (ADC) map was generated, and means ADC values were determined from measurements of pleural thickening. Results:The mean ADC values were 1.94±0.09×10-3 mm 2 /s and 0.84±0.05×10 -3 mm 2 /s in benign pleural disease and MPM, respectively. The mean ADC value in the malignant group was significantly lower than in the benign group (p<0.05). Conclusion:Our results show that dMRI and ADC values are useful for differentiating between benign and malignant pleural thickening in asbestos-related pleural diseases. dMRI gives clues for the interpretation of whether pleural thickening is benign or malignant and can assist in the early detection of MPM.

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“…Not surprisingly, 18FDG-PET has been found to be superior to CT for disease localization and staging, and for surgical decision-making [39][40][41][42][43]. 18FDG-PET is also more sensitive for the detection of nodal, chest wall invasion and distant metastases [44][45][46], as well as port-site disease [47]. More recently, PET imaging has also been adopted to guide radiation planning [48,49] The degree of 18FDG uptake on PET imaging can be measured semi-quantitatively (e.g., using the maximum standardized uptake value, SUVmax), or using more robust quantitative measurements that are derived using more prescribed data acquisition and analysis (e.g., PET Response Criteria in Solid Tumors (PERCIST) [50]), with the aim of reducing measurement variability between studies [50].…”

Section: Fdg-pet Imagingmentioning

confidence: 99%