18F-FDG PET/CT in staging and delineation of radiotherapy volume for head and neck cancer

Pedraza, S.; Ruiz-Alonso, A.; Hernández-Martínez, Ana Cristina; Cabello, E.; Lora, David; Pérez-Regadera, J.

doi:10.1016/j.remnie.2018.08.003

Cited by 4 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MRI findings were suggestive for tumor recurrence, whereas only a faint uptake on 18 F-FET PET (c) and fused PET/MRI (d) was seen in both lesions, a finding typical for radiation necrosis. Radiation necrosis was subsequently confirmed by histopathology positive lymph nodes [48,49]. Moreover, first data suggests that the use of PET/CT for radiation planning could significantly improve the local tumor control, regional control and even survival [54].…”

Section: Head and Neck Cancermentioning

confidence: 95%

See 1 more Smart Citation

Recent advances of PET imaging in clinical radiation oncology

et al. 2020

View full text Add to dashboard Cite

Radiotherapy and radiation oncology play a key role in the clinical management of patients suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast-enhanced CT and MRI are widely available and are usually used to improve the target volume delineation for subsequent radiotherapy. Moreover, these modalities are also used for treatment monitoring after radiotherapy. However, some diagnostic questions cannot be sufficiently addressed by the mere use standard morphological imaging. Therefore, positron emission tomography (PET) imaging gains increasing clinical significance in the management of oncological patients undergoing radiotherapy, as PET allows the visualization and quantification of tumoral features on a molecular level beyond the mere morphological extent shown by conventional imaging, such as tumor metabolism or receptor expression. The tumor metabolism or receptor expression information derived from PET can be used as tool for visualization of tumor extent, for assessing response during and after therapy, for prediction of patterns of failure and for definition of the volume in need of dose-escalation. This review focuses on recent and current advances of PET imaging within the field of clinical radiotherapy / radiation oncology in several oncological entities (neuro-oncology, head & neck cancer, lung cancer, gastrointestinal tumors and prostate cancer) with particular emphasis on radiotherapy planning, response assessment after radiotherapy and prognostication.

show abstract

Section: Head and Neck Cancermentioning

confidence: 95%

“…PET/CT facilitates contouring for (chemo-) radiotherapy (CRT) and it significantly influences dose painting in radiation planning. In about 25% of patients with disease of unknown primary, location is revealed by 18 F-FDG-PET/CT [47][48][49][50][51][52].…”

Section: Head and Neck Cancermentioning

confidence: 99%

Recent advances of PET imaging in clinical radiation oncology

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although evidence supports that PET/CT may impact planning by changing the accuracy and delineation of gross tumor volumes, only 0% to 19% of the patients in those cohorts have sinonasal malignancies. [41][42][43][44] No study specifically investigating the role of PET scans for radiotherapy treatment planning in patients with sinonasal malignancies has been performed. Thus, further investigations should be performed before any conclusions can be drawn.…”

Section: Sinonasal Carcinomasmentioning

confidence: 99%

The Role of Positron Emission Tomography for the Management of Sinonasal Malignancies: A Systematic Review

El-Adem,

Yang,

Gudis

2023

Am J Rhinol�Allergy

View full text Add to dashboard Cite

Background Positron emission tomography (PET) scan is a valuable imaging modality widely used in the management of cancers. Its usage is well defined for most head and neck malignancies. However, there is a lack of consensus regarding the utility of PET scan for sinonasal malignancies. This is highlighted by the latest international consensus statement on endoscopic skull base surgery. Objective This systematic review aims to clarify the role of PET scan in the management of sinonasal malignancies. Methods We conducted a comprehensive literature search using PubMed, MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane databases for research studies of interest. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) updated statement was used to guide the review. Results In total, 1807 articles were assessed for eligibility. Thirty-nine original papers, published between 2004 and 2021, met inclusion criteria. Seven articles focused on the role of PET scan for inverted papilloma, 23 for sinonasal carcinoma, 4 for melanoma, and 3 for lymphoma, and finally, 3 articles focused on the use of specific PET scan tracers for sinonasal malignancies. Qualitative summaries for each potential role of PET scans were provided. In general, included studies were retrospective in nature with low level of evidence. Conclusions In general, and across all types of sinonasal malignancies, PET scan yielded positive results regarding detection and initial staging. It was also considered as the modality of choice for detection of distant metastases, except in the case of sinonasal lymphoma. PET scan's main limit resides in its inability to detect lesions in or close to the metabolic activity of the brain.

show abstract

“…At present, structural imaging techniques such as computed tomography and magnetic resonance imaging are considered the gold standard for tumor identification. MRI can provide additional information to help physicians detect soft tissue tumors and nodal diseases as it has superior soft tissue contrast resolution [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and Radiotherapy Planning in Head and Neck Squamous Carcinoma: A Retrospective Study of 46 Patients

Pham,

Garai,

Árpád

et al. 2023

Med Sci Monit

View full text Add to dashboard Cite

Background Positron emission tomography/computed tomography (PET/CT) using fluorodeoxyglucose (FDG) is essential in oncology for precise tumor delineation. This study evaluated FDG PET/CT’s impact on therapeutic decisions in head and neck cancer, comparing metabolic tumor volumes (MTV) measured by different methods with radiotherapy targets, crucial for treatment planning and patient outcomes. Material/Methods We retrospectively analyzed 46 patients with histologically confirmed head and neck cancer who underwent FDG PET/CT examination before radiotherapy. The mean age was 62 years (46–78 years). Then, we calculated MTV of the primary tumor or local recurrence using a local threshold of 41% of the standard uptake volume (SUV) corrected for lean body mass (SULmax) of the lesion and absolute threshold of SUV 2.5. Descriptive analysis of the recruited patients was assessed based on the clinical database (Medsol). Results The study included 45 patients with squamous carcinoma and 1 with sarcoid cell carcinoma. PET/CT examination led to therapeutic decision changes in 11 cases. No significant difference was found in median values of Gross Tumor Volume (GTV) and MTV absolute (p=0.130). However, significant differences were observed in MTV local, MTV absolute, and GTV median values (p<0.001), with both MTVs showing significant correlation with GTV (p<0.01), especially MTV absolute (r=0.886). Conclusions FDG PET/CT examination prior to radiotherapy significantly influences therapeutic decisions in head and neck cancer patients. Based on our findings, the absolute threshold method (SUV: 2.5) appears to be an effective approach for calculating MTV for radiotherapy planning purposes.

show abstract

18F-FDG PET/CT in staging and delineation of radiotherapy volume for head and neck cancer

Cited by 4 publications

References 25 publications

Recent advances of PET imaging in clinical radiation oncology

Recent advances of PET imaging in clinical radiation oncology

The Role of Positron Emission Tomography for the Management of Sinonasal Malignancies: A Systematic Review

Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and Radiotherapy Planning in Head and Neck Squamous Carcinoma: A Retrospective Study of 46 Patients

Contact Info

Product

Resources

About