18F-FDG PET/CT in cardiovascular infection and inflammation

Casáns-Tormo, I.; Alcalá-López, J.E.; Espinet-Coll, C.; Pubul-Núñez, V.; Martínez-Rodríguez, I.

doi:10.1016/j.remnie.2021.09.008

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Images at the time of PET/CT were interpreted by different physicians with a diverse expertise in the field of inflammation, and medical reports might have impacted on the clinical diagnosis. Indeed, reader 1′s sensitivity was lower than that generally reported in the literature [ 10 , 11 , 20 ]. However, this was expected, since for the analysis, we did not use medical reports, but we visually re-assessed all images, rigorously applying the diagnostic criteria recommended by the current guidelines [ 11 ].…”

Section: Discussionmentioning

confidence: 57%

“…Although patient demographics were consistent with the expected age and sex distributions for LVV [ 3 ], some conditions such as atherosclerosis were reported to affect the vascular [ 18 F]FDG signal. We considered age as a surrogate of atherosclerosis and accordingly, we divided and analyzed the population in young (≤65 years) and elderly (>65 years) subjects, although many other factors, conditions, and diseases including cardiovascular ones, might influence, beyond age, the vascular [ 18 F]FDG uptake [ 17 , 18 , 19 , 20 ]. Diagnostic accuracy was higher in the young than in the aged patients for both readers, suggesting that age may act as a confounder.…”

Section: Discussionmentioning

confidence: 99%

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[18F]FDG PET/CT in Large Vessel Vasculitis: The Impact of Expertise and Confounders on Image Analysis

et al. 2022

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Background: Diagnosis of vasculitis is challenging. To avoid invasive approaches, clinical guidelines recommend the use of diagnostic imaging. This study aimed at evaluating the diagnostic accuracy of [18F]-fluorodeoxyglucose ([18F]FDG) position emission tomography/computed tomography (PET/CT) in large vessel vasculitis (LVV) and how this is affected by inter-operator variability. Methods: A total of 279 patients who performed [18F]-FDG PET/CT for suspicion of LVV were retrospectively analyzed. We tested the qualitative and semi-quantitative analysis and parameters influencing image quality and interpretation. Exams were evaluated by two readers with different experience and their performance was compared. Results: LVV diagnosis was confirmed in 81 patients. [18F]-FDG PET/CT accuracy was 73% and 67% for the expert reader and less experienced reader, respectively. The expert reader overall performed better than the less experienced one, with higher accuracy in patients with normal BMI (77.3 vs. 63.8%), normal level of glycemia (73.3 vs. 65%), younger age (76.6 vs. 68.2%), and when no therapy was in course at time of imaging (76.7 vs. 66.7%). The diagnostic performance of both readers did not improve using semi-quantitative parameters. Conclusions: We confirmed the appropriateness of the recommended criteria for image acquisition and interpretation, underlining the importance of experience in image interpretation for the optimal diagnostic performance of [18F]FDG PET/CT in vasculitis.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

[18F]FDG PET/CT in Large Vessel Vasculitis: The Impact of Expertise and Confounders on Image Analysis

et al. 2022

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“…Estimated price for MRI is around 300-800$ [88]. Hybrid functional imaging and anatomical modalities, such as PET/CT [91], [92] or cardiac MR/PET [93], [94] are promising and reliable procedures to study structural, functional, and metabolic changes in cardiovascular system. Hybrid methods can be extremely valuable in early disease diagnosis, differentiating active from stable conditions of tumors, monitoring disease progression and the response to therapy in oncology cases [95], [96].…”

Section: Imaging Modalities For Functional Assessmentmentioning

confidence: 99%

Imaging structural and mechanical properties in cardiovascular tissue using optical polarization tractography

Azinfar¹

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[EMBARGOED UNTIL 6/1/2023] Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the US. Every 36 seconds, one person dies from CVD [1]. Structural deficiencies and secondary changes induced by either abnormal functioning of related mechanisms or irregular physiological loading are deciding factors in the development of CVD. CVD's high mortality rate has increasingly motivated efforts to better understand the underlying mechanisms associated with normal structure and their CVD-provoked modifications. Thorough knowledge about disease-driven events at the tissue and cellular level eventually leads to early diagnosis prior to the appearance of clinical symptoms at the organ-level and the cardiovascular system-level. Common clinical imaging technologies such as MRI, PET, and CT are well-known to cover organ, and system-level events; however, they suffer from low resolution, making it difficult to resolve delicate layers in cardiovascular tissues. On the other hand, microscopic techniques provide high resolution, however, they are limited by their small field of view and their insufficient effective imaging depth. To address these issues, this dissertation focuses on characterization of the fiber architecture of Extra Cellular Matrix (ECM) in cardiovascular tissues, including carotid artery and Mitral Valve (MV) tissues, by utilizing a newly-developed nondestructive, micrometer-scale depth-resolved imaging technique based on locally-polarized sensitive optical coherence tomography (PSOCT) measurements. The system can measure intrinsic optical properties of fibrous tissues, such as birefringence and fiber orientation, and visualize them in three-dimensional (3D) space. The orientation data is used to trace elastin and collagen fibers using a tractography method in different layers of ECM. An automatic multi-feature image segmentation approach was developed to extract MV layers and quantify the layer-specific characteristics of MVs such as thickness, fiber orientation, and alignment. These parameters play crucial roles in normal biomechanical functioning in MV, and their alterations are associated with disease progression. Furthermore, the interrelationship between the structural parameters and mechanical responses of MV tissue was studied by designing and 3D printing a mechanical setup to integrate PSOCT imaging with biaxial loading of the tissue. Additional information was obtained by visualizing layer-specific deformation of fiber architecture in anterior leaflet of mitral valve tissue in response to equilibrium biaxial loading. To measure 3D displacement maps and 3D strain tensors across the stretched tissue, a 3D optical coherence elastography (OCE) technique based on intensity volumes was developed. Simultaneous structure and elastography imaging were applied to reveal detailed location-specific and layer-specific mechanical anisotropy in anterior leaflet of MV tissues. Special effort was made in this dissertation to reveal detailed fiber structures and their interrelation with mechanical functionality in cardiovascular tissues; these relationships can remarkably improve mechanical modeling and tissue engineering in this field. These studies will facilitate understanding advanced diseased-related structural remodeling in response to simulated physiological or mechanical disease environments. In addition, due to the fast progress of fiber optic technology in PSOCT imaging, local polarization sensitive measurements can be extended to in vivo studies in the future.

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18F-FDG PET/CT in left ventricular assist device infections: In-depth characterization and clinical implications

Devesa,

Rashed,

Moss

et al. 2024

The Journal of Heart and Lung Transplantation

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18F-FDG PET/CT in cardiovascular infection and inflammation

Cited by 3 publications

References 36 publications

[18F]FDG PET/CT in Large Vessel Vasculitis: The Impact of Expertise and Confounders on Image Analysis

[18F]FDG PET/CT in Large Vessel Vasculitis: The Impact of Expertise and Confounders on Image Analysis

Imaging structural and mechanical properties in cardiovascular tissue using optical polarization tractography

18F-FDG PET/CT in left ventricular assist device infections: In-depth characterization and clinical implications

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