18F-FDG PET/CT Findings in a Patient with Chikungunya Virus Infection

Rose, Mandy; Kjaer, Anna Sophie L; Markova, Elena; Graff, Jesper

doi:10.3390/diagnostics7030049

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…However, this current study confirmed that in DENV, spleen [ 18 F]FDG uptake is still sufficiently sensitive as a possible imaging biomarker for disease and more closely recapitulates the clinical PET/CT observations in DENV patients [ 11 , 12 ]. Aside from DENV and ZIKV, lymphoid tissue [ 18 F]FDG uptake has also been reported in other viral infections, seen in [ 18 F]FDG-PET images of patients infected with chikungunya virus [ 39 ], reactivated Epstein-Barr virus [ 40 – 42 ], and reactivated varicella zoster virus or shingles [ 43 ]. Lymphoid tissue FDG uptake was also captured in non-human primate models of monkeypox virus infection [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of [18F]FDG-PET as a biomarker of lymphoid tissue disease and inflammation in Zika virus infection

Victorio

Ong

Tham

et al. 2022

Eur J Nucl Med Mol Imaging

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Purpose Zika (ZIKV) is a viral inflammatory disease affecting adults, children, and developing fetuses. It is endemic to tropical and sub-tropical countries, resulting in half the global population at risk of infection. Despite this, there are no approved therapies or vaccines against ZIKV disease. Non-invasive imaging biomarkers are potentially valuable tools for studying viral pathogenesis, prognosticating host response to disease, and evaluating in vivo efficacy of experimental therapeutic interventions. In this study, we evaluated [18F]fluorodeoxyglucose ([18F]FDG)-positron emission tomography (PET) as an imaging biomarker of ZIKV disease in a mouse model and correlated metabolic tracer tissue uptake with real-time biochemical, virological, and inflammatory features of tissue infection. Methods [18F]FDG-PET/CT imaging was performed in an acute, lethal ZIKV mouse infection model, at increasing stages of disease severity. [18F]FDG-PET findings were corroborated with ex vivo wholemount-tissue autoradiography and tracer biodistribution studies. Tracer uptake was also correlated with in situ tissue disease status, including viral burden and inflammatory response. Immune profiling of the spleen by flow cytometry was performed to identify the immune cell subsets driving tissue pathology and enhancing tracer uptake in ZIKV disease. Results Foci of increased [18F]FDG uptake were consistently detected in lymphoid tissues—particularly the spleen—of ZIKV-infected animals. Splenic uptake increased with disease severity, and corroborated findings in tissue pathology. Increased splenic uptake also correlated with increased viral replication and elevated expression of pro-inflammatory cytokines within these tissues. ZIKV-infected spleens were characterized by increased infiltration of myeloid cells, as well as increased proliferation of both myeloid and lymphoid cells. The increased cell proliferation correlated with increased tracer uptake in the spleen. Our findings support the use of [18F]FDG as an imaging biomarker to detect and track ZIKV disease in real time and highlight the dependency of affected tissue on the nature of the viral infection. Conclusion [18F]FDG uptake in the spleen is a useful surrogate for interrogating in situ tissue viral burden and inflammation status in this ZIKV murine model.

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Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of [18F]FDG-PET as a biomarker of lymphoid tissue disease and inflammation in Zika virus infection

Victorio

Ong

Tham

et al. 2022

Eur J Nucl Med Mol Imaging

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“…High expression of prostaglandins stimulates nociceptors that increase sensitivity to pain and increase osteoclastic activity, resulting in osseous erosion [28]. Additional sites of inflammation include lymph nodes, skin, liver, and spleen [29]. The chronic phase of disease is typically distal, symmetric, and polyarticular, involving the hands, wrists, and ankles [23].…”

Section: Chikungunya Fevermentioning

confidence: 99%

Imaging of Emerging Infectious Diseases

et al. 2019

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“…Elevated levels of prostaglandins enhance the activation of nociceptors, which heightens pain sensitivity and promotes the activity of osteoclasts, leading to the erosion of bone tissue[28]. Other areas where inflammation may occur include lymph nodes, skin, liver, and spleen[29]. The chronic stage of the illness usually affects the hands, wrists, and ankles in a distal, symmetric, and polyarticular manner[23].…”

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confidence: 99%

Radiological Manifestations and Imaging-Guided Interventions in Infectious Diseases: (Review Artical)

ALSHAMMARY

2021

The Medical Journal of Cairo University

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Background: The frequency of emerging infectious illnesses has reached unprecedented levels, making it crucial to comprehend their management in an ever more interconnected global society. Aim of Study:This study provides a comprehensive analysis of the existing literature on the use of radiography in the diagnosis and treatment of Ebola (EVD), Zika (ZVD), Chikungunya (CHIKF), H1N1, Middle East Respiratory (MERS), and Severe Acute Respiratory Syndrome (SARS) viruses.Methods: An extensive literature search was performed using the PubMed database.Results: Advanced methods are necessary to properly use portable imaging in EVD in order to avoid the transmission of illness inside a healthcare setting. Antenatal ultrasonography in ZVD has the capability to promptly identify fetal anomalies, enabling the provision of appropriate treatment and assistance to families afflicted by such conditions. Imaging is valuable for evaluating the degree of chronic CHIKF involvement and tracking the effectiveness of therapy. Chest radiography and CT scans are crucial for diagnosing and monitoring viral diseases that predominantly affect the respiratory system, such as H1N1, MERS, and SARS. Conclusion:Radiology has a diverse function in developing infectious illnesses, necessitating knowledge of disease transmission and safe imaging methods, as well as understanding the imaging characteristics that impact clinical care.

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18F-FDG PET/CT Findings in a Patient with Chikungunya Virus Infection

Cited by 4 publications

References 6 publications

Preclinical evaluation of [18F]FDG-PET as a biomarker of lymphoid tissue disease and inflammation in Zika virus infection

Preclinical evaluation of [18F]FDG-PET as a biomarker of lymphoid tissue disease and inflammation in Zika virus infection

Imaging of Emerging Infectious Diseases

Radiological Manifestations and Imaging-Guided Interventions in Infectious Diseases: (Review Artical)

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