18F-FDG PET/CT Findings in a Patient With Primary Mucinous Cystadenocarcinoma of the Breast

Hu, Yujing; Tian, Congna; Zhang, Xinchao; Wei, Qiang; Bian, Yanzhu

doi:10.1097/rlu.0000000000002902

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…The age of onset of breast MCA has been reported as 41–96 years (average: 61.6 years), and most cases occur in those aged >60 years [3‒32]. The majority of cases of breast MCA were detected early or were locally advanced.…”

Section: Discussionmentioning

confidence: 99%

Mucinous Cystadenocarcinoma of the Breast with Bone Metastases: First Case Report and Literature Review

Gong,

Geng,

Liu

et al. 2023

Oncol Res Treat

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Introduction: Mucinous cystadenocarcinoma (MCA) of the breast is an extremely rare type of breast carcinoma. Since its biological characteristics, treatment options, and clinical outcomes are unclear, there is a lack of consensus regarding the optimal management of this disease. Thus, our single case report will aid our understanding of its natural history, prognostic factors, and treatment strategies. Case presentation: We present a 54-year-old woman with a case of advanced MCA of the breast accompanied by a huge breast mass, lymph node involvement, and distant bone metastases. We diagnosed primary breast MCA through clinical examination, imaging, and immunohistochemical assessments. Subsequently, the patient was treated with a regimen of nab-paclitaxel and bevacizumab, resulting in a significant clinical response. Progression-free survival was maintained during the 6-month follow-up period. Conclusion: We present the first report worldwide of a rare case of MCA of the breast with a large local mass and bone metastasis. Our report adds to the limited literature on this rare breast cancer subtype and highlights the importance of accurate diagnosis and appropriate management of aggressive breast tumors.

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Section: Discussionmentioning

confidence: 99%

Mucinous Cystadenocarcinoma of the Breast with Bone Metastases: First Case Report and Literature Review

Gong,

Geng,

Liu

et al. 2023

Oncol Res Treat

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“…Additionally, we included N0 cases in the analysis. Preoperative imaging does not definitively exclude axillary nodal metastasis, so clinical N0 patients must proceed to SLNB [17]. Therefore, both the N0 and LNB groups underwent the same procedure.…”

Section: Discussionmentioning

confidence: 99%

The new perspective of PET/CT for axillary nodal staging in early breast cancer patients according to ACOSOG Z0011 trial PET/CT axillary staging according to Z0011

Kong¹,

Choi

2021

Nuclear Medicine Communications

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Objective Post Z0011 trial, axillary lymph node dissections (ALNDs) can be performed in patients with ≥3 positive axillary lymph nodes (ALNs). We investigated the diagnostic performance of 18F-fluorodeoxyglucose PET/computed tomography (FDG PET/CT) to predict ≥3 metastasis [high nodal burden (HNB)]. Methods We retrospectively analyzed preoperative FDG PET/CT from January 2010 to June 2012. Patients had clinical T1-2N0 primary invasive breast cancer and underwent breast-conserving surgery with sentinel lymph node biopsy ± ALND. All suspicious ALNs were counted considering FDG-avidity with morphologic changes. Images were considered positive if the axillary basin took up more FDG than the surrounding tissue. On CT, abnormal ALNs were round/ovoid or had cortical thickening with contrast enhancement. PET/CT results were compared with the histology and follow-up findings. Results In total, 221 females with 224 axillae were enrolled; 161 had negative, 53 had 1–2 metastasis [low nodal burden (LNB)] and 10 had HNB. The sensitivity, specificity, negative predictive value and positive predictive value of PET/CT for HNB were 70, 100, 98.6 and 100%, respectively. There was a correlation between the number of suspicious ALNs on PET/CT and the metastatic nodes on final histology. There were no significant differences in age, tumor size and FDG-avidity between patients with negative or LNB and HNB. During follow-up, 25 patients had a recurrence. The three false-negative patients did not show recurrence. Conclusion Preoperative PET/CT predicts HNB with high accuracy and is useful for evaluating clinical T1-2N0 invasive breast cancer.

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“…In addition to the above commonly seen features of metaplastic breast carcinoma, matrix-producing carcinoma of the breast also presented as well-demarcated nodule or mass with prominent central necrosis 4,5. This case indicates that matrix-producing carcinoma of the breast should be differentiated from other breast lesions with increased 18 F-FDG avidity on PET/CT, including hyperplasia, inflammation, and infection; benign tumor; and primary or secondary malignancy [6][7][8].…”

mentioning

confidence: 92%

“…4,5 This case indicates that matrix-producing carcinoma of the breast should be differentiated from other breast lesions with increased 18 F-FDG avidity on PET/CT, including hyperplasia, inflammation, and infection; benign tumor; and primary or secondary malignancy. [6][7][8]…”

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confidence: 99%

18F-FDG PET/CT in a Patient With Matrix-Producing Carcinoma of the Breast

Chen

et al. 2021

Clin Nucl Med

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A 47-year-old woman presented with a large mass in the upper inner quadrant of the left breast. 18 F-FDG PET/CT revealed a low-density left breast mass with heterogeneous ring-like 18 F-FDG uptake. Core needle biopsy of the tumor revealed a rare subtype of metaplastic breast carcinoma, matrix-producing carcinoma. The tumor size slightly decreased after 6 cycles of neoadjuvant chemotherapy with docetaxel and epirubicin. The left breast was entirely resected subsequently, and the matrix-producing carcinoma of the breast was ultimately diagnosed.

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18F-FDG PET/CT Findings in a Patient With Primary Mucinous Cystadenocarcinoma of the Breast

Cited by 5 publications

References 26 publications

Mucinous Cystadenocarcinoma of the Breast with Bone Metastases: First Case Report and Literature Review

Mucinous Cystadenocarcinoma of the Breast with Bone Metastases: First Case Report and Literature Review

The new perspective of PET/CT for axillary nodal staging in early breast cancer patients according to ACOSOG Z0011 trial PET/CT axillary staging according to Z0011

18F-FDG PET/CT in a Patient With Matrix-Producing Carcinoma of the Breast

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