18F-FDG-PET/CT as an indicator for resection of pulmonary epithelioid hemangioendothelioma

Watanabe, Sadahiro; Yano, Fumihiko; Kita, Tamotsu; Soga, Shigeyoshi; Shinmoto, Hiroshi; Kosuda, Shigeru; Ozeki, Yuichi; Aida, Shinsuke; Sakata, Ikuhiro

doi:10.1007/s12149-007-0159-z

Cited by 33 publications

(22 citation statements)

References 11 publications

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“…[20–22] Indeed, most patients who underwent PET/CT in our study showed increased FDG uptake at the corresponding lung lesions on CT. There was a trend of a wider range of SUVmax in the multinodular pattern, compared with relatively higher SUVmax in diffuse pleural and nodule/mass with pleural pattern.…”

Section: Discussionmentioning

confidence: 93%

Epithelioid hemangioendothelioma in the thorax

et al. 2016

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Little is known about prognostic factors in epithelioid hemangioendothelioma (EHE). We aimed to identify prognostic factors among various clinicopathologic and imaging features of thoracic EHEs.Forty-two patients (male:female = 20:22; median age, 49 years) of EHEs with (n = 19) and without (n = 23) thoracic involvement were included. We reviewed electronic medical records for clinical information and computed tomography (CT) features for thoracic involvement. Differences in demographics and survival outcomes of patients with and without thoracic involvement were assessed. We also estimated overall survival.The most common pattern of thoracic involvement was multiple pulmonary nodules (n = 10), followed by parenchymal tumor with pleural invasion (n = 4), reticulonodular opacities (n = 3), and diffuse pleural thickening (n = 2). No significant difference in survival was found between the thoracic EHE group and nonthoracic EHE group (P = 0.68). Among 4 different thoracic involvement types, the lung multinodular pattern tended to demonstrate longer median survival (8.5 months) than other patterns, whereas the shortest median survival (1 month) was observed for the nodule/mass with pleural involvement pattern (P = 0.038).CT manifestations of thoracic EHEs are classified into 4 patterns, of which lung multinodular pattern is associated with longer survival. Survival is not different between patients with and without thoracic involvement.

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Section: Discussionmentioning

confidence: 93%

Epithelioid hemangioendothelioma in the thorax

et al. 2016

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“…18 F-FDG-PET/CT was recently reported by Watanabe et al as a useful diagnostic tool for indicating the suitability of resection for PEH. 3 They presented a case of PEH with two foci (one was 2.5 cm diameter; the size of other was not described), both of which had increased 18 F-FDG uptake. The fi rst case of PEH with 18 F-FDG positive was reported by Fagen et al However, the detailed clinical characteristics were not documented except that it measured 2 × 1 cm.…”

Section: Discussionmentioning

confidence: 99%

“…However, 18 F-fl uorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG-PET/ CT) was recently reported as a useful diagnostic tool. 3 We describe herein two cases of PEH, including the results of 18 F-FDG-PET/CT, and discuss them along with a review of the current literature.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary epithelioid hemangioendothelioma

Mizuno

Iwata

Shirahashi

et al. 2011

Gen Thorac Cardiovasc Surg

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We report two cases of pulmonary epithelioid hemangioendothelioma (PEH). Both patients presented with multiple bilateral pulmonary nodules, <10 mm diameter, on computed tomography (CT). Multiple pulmonary metastases were considered, but no primary malignant lesion was detected by other imaging modalities including (18)F-fl uorodeoxyglucose positron emission tomography ((18)F-FDG-PET)/CT. Moreover, the nodules did not show increased uptake of (18)F-FDG. We performed pulmonary wedge resections by video-assisted thoracoscopic surgery (VATS). Histological and immunohistochemical analysis revealed PEH in both. Positivity for the monoclonal antibody MIB-1 in the tumor cells was 5% in the fi rst case and 5%-10% in the second case. Slow tumor progression was detected with CT in the second case. Although (18)F-FDG PET/CT is effective for screening other malignant lesions, it does not appear to be of direct use in the diagnosis and surgical planning of PEH. Pathological diagnosis by VATS is the most effective method. MIB-1 positivity should be analyzed as to whether it is a prognostic factor of PEH.

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“…When SUV is high on FDG-PET, it is important for the lesion to be differentiated from a malignant tumor. However, some reports have shown that SUV is high even in benign tumors such as granulomas and inflammatory lesions [6][7][8][9]. In malignant tumors, SUVmax tends to be higher when the tumor grade is higher [10,11].…”

Section: Discussionmentioning

confidence: 99%

18F-FDG-PET/CT findings in primary pulmonary mixed squamous cell and glandular papilloma

et al. 2010

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A 55-year-old female had an abnormal shadow on chest radiograph. Computed tomography (CT) revealed a 26-mm tumor mass in the left upper lobe. No malignant findings were obtained by bronchoscopic cytology or histopathological diagnostics, but on positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) examination the maximum SUV was 9.01 in accordance with the tumor mass shadow on CT. Video-assisted thoracoscopic surgery was performed as clinically suspected of lung cancer, and the diagnosis was pulmonary mixed squamous cell and glandular papilloma (PMSGP). Primary PMSGP is extremely rare, and this is the first to describe the PET findings of this disease.

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18F-FDG-PET/CT as an indicator for resection of pulmonary epithelioid hemangioendothelioma

Cited by 33 publications

References 11 publications

Epithelioid hemangioendothelioma in the thorax

Epithelioid hemangioendothelioma in the thorax

Pulmonary epithelioid hemangioendothelioma

18F-FDG-PET/CT findings in primary pulmonary mixed squamous cell and glandular papilloma

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