18F-FDG PET, combined FDG-PET/CT and MRI for evaluation of bone marrow infiltration in staging of lymphoma: A systematic review and meta-analysis

Wu, Lian‐Ming; Chen, Fangyuan; Jiang, Xiaoxing; Gu, Heng; Yin, Yan; Xu, Jianrong

doi:10.1016/j.ejrad.2010.11.020

Cited by 59 publications

(33 citation statements)

References 55 publications

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“…A meta-analysis by Wu et al (25) demonstrated almost equal sensitivities (;90%) of 18 F-FDG PET/CT and MR for diagnosing lymphoma with bone marrow involvement. The specificity of MR has been reported to be lower than that of 18 F-FDG PET because posttherapeutic changes, such as bone marrow edema, necrotic tissue, or age-dependent changes in the appearance of bone marrow in children, may lead to misinterpretation (25,26). A retrospective analysis of the diagnostic value of combined and coregistered 18 F-FDG PET/MR in pediatric oncology (mainly lymphoma) did not miss any bone or bone marrow lesions relative to an analysis of each modality separately.…”

Section: Lymphomamentioning

confidence: 99%

Potential Pediatric Applications of PET/MR

et al. 2014

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Medical imaging with multimodality and whole-body technologies has continuously improved in recent years. The advent of combined modalities such as PET/CT and PET/MR offers new tools with an exact fusion of molecular imaging and high-resolution anatomic imaging. For noninvasive pediatric diagnostics, molecular imaging and whole-body MR have become important, especially in pediatric oncology. Because it has a lower radiation exposure than PET/CT, combined PET/MR is expected to be of special use in pediatric diagnostics. This review focuses on possible pediatric applications of PET/MR hybrid imaging, particularly pediatric oncology and neurology but also the diagnosis of infectious or inflammatory diseases.

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Section: Lymphomamentioning

confidence: 99%

Potential Pediatric Applications of PET/MR

et al. 2014

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“…PET-CT was also a highly sensitive and specific method for diagnosing bone marrow involvement in lymphomas (15,16). However, its reliability differed depending on the histological type of the lymphoma, and a bone marrow biopsy is still needed (12,16). In this study, the thyroid gland and prostate were the other organs with a diffuse infiltrative involvement and diffuse uptake of 18 F-FDG.…”

Section: Discussionmentioning

confidence: 89%

“…The results showed that the initial staging of splenic lymphomatous involvement, sensitivity and specificity of PET-CT were higher than those of the other diagnostic modalities alone (17,18). PET-CT was also a highly sensitive and specific method for diagnosing bone marrow involvement in lymphomas (15,16). However, its reliability differed depending on the histological type of the lymphoma, and a bone marrow biopsy is still needed (12,16).…”

Section: Discussionmentioning

confidence: 92%

“…Several studies in the literature reported that 18 F-FDG PET-CT was an effective and reliable method to evaluate lymphomas in the pre-treatment and post-treatment periods; it was shown to be superior to CT for the observation of normal-sized but involved lymph nodes and diffusely infiltrated sites, such as the spleen or bone marrow (7,9,(11)(12)(13)(14)(15)(16)(17)(18). The role of PET-CT for splenic involvement in patients with lymphoma was evaluated by different studies.…”

Section: Discussionmentioning

confidence: 99%

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Fluorine-18 fluorodeoxyglucose PET-CT for extranodal staging of non-Hodgkin and Hodgkin lymphoma

Ömür

Baran

Oral³

et al. 2014

Diagn Interv Radiol

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NUCLEAR MEDICINE AND MOLECULAR IMAGINGF-FDG PET-CT imaging, following a diagnostic contrast-enhanced CT (CE-CT) performed within the last month, were included in our study. A total of 129 PET-CT images, and all radiologic, clinical, and pathological records of these patients were retrospectively reviewed. RESULTSIn total, 137 hypermetabolic extranodal infiltration sites were detected by 18 F-FDG PET-CT in 62 of 110 patients. There were no positive findings by CE-CT that reflected organ involvement in 40 of 137 18 F-FDG-positive sites. The κ statistics revealed fair agreement between PET-CT and CE-CT for the detection of extranodal involvement (κ=0.60). The organs showing a disagreement between the two modalities were the spleen, bone marrow, bone, and thyroid and prostate glands. In all lesions that were negative at CE-CT, there was a diffuse 18 F-FDG uptake pattern in the PET-CT images. The frequency of extranodal involvement was 51% and 58% in Hodgkin and non-Hodgkin lymphoma patients, respectively. There was a high positive correlation between the maximum standardized uptake values of the highest 18 F-FDG-accumulating lymph nodes and extranodal sites (r=0.67) in patients with nodal and extranodal involvement. CONCLUSION 18 F-FDG PET-CT is a more effective technique than CE-CT for the evaluation of extranodal involvement in Hodgkin and non-Hodgkin lymphoma patients. PET-CT has a significant advantage for the diagnosis of diffusely infiltrating organs without mass lesions or contrast enhancement compared to CE-CT.

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“…This is especially significant in relation to patients with chronically increased PSA values and negative biopsy results, for whom a PET/MR scan allows for more accurate specification of the biopsy location [37]. There is a large amount of reports regarding 18 F-FDG PET/CT in the assessment of Hodgkin and non-Hodgkin lymphoma staging, indicating high accuracy, which has led to the widespread application of this method [38][39][40]. PET/MR scans may be an alternative to PET/CT scans for young patients, especially children, in order to reduce exposure to ionizing radiation; however, at the moment there is only little data on the subject [41].…”

Section: Reviewmentioning

confidence: 99%