18F- and 11C-labelling of quantum dots with n.c.a. [18F]fluoroethyltosylate and [11C]methyliodide: a feasibility study

Patt, Marianne; Schildan, Andreas; Habermann, Bernd; Mishchenko, O; Patt, J. T.; Sabri, Osama

doi:10.1007/s10967-009-0356-4

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…In this work we covalently bound the label N-succinimidyl-4-[ 18 F]-fluorobenzoate ([ 18 F]-SFB) to the C(AuNP)LPFFD conjugate. 18 F has been used to label a variety of nanoparticles, including magnetic-upconversion nanophosphors, 14 quantum dots, 15 and lipid-shelled microbubbles, 16 and recently in our group diamond nanoparticles were labeled with [ 18 F]-SFB. 17 To the best of our knowledge, this study represents the first time that AuNPs have been labeled with the radioisotope 18 F for PET imaging.…”

Section: ■ Introductionmentioning

confidence: 99%

Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

et al. 2012

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Gold nanoparticles (AuNPs) have been extensively used in biological applications because of their biocompatibility, size, and ease of characterization, as well as an extensive knowledge of their surface chemistry. These features make AuNPs readily exploitable for biomedical applications, including drug delivery and novel diagnostic and therapeutic approaches. In a previous work, we studied ex vivo distribution of the conjugate C(AuNP)-LPFFD for its potential uses in the treatment of Alzheimer's disease. In this study, we covalently labeled the conjugate with [(18)F]-fluorobenzoate to study the in vivo distribution of the AuNP by positron emission tomography (PET). After intravenous administration in rat, the highest concentration of the radiolabeled conjugate was found in the bladder and urine with a lower proportion in the intestine, demonstrating progressive accumulation compatible with biliary excretion of the conjugate. The conjugate also accumulated in the liver and spleen. PET imaging allowed us to study the in vivo biodistribution of the AuNPs in a noninvasive and sensitive way using a reduced number of animals. Our results show that AuNPs can be covalently and radioactively labeled for PET biodistribution studies.

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Section: ■ Introductionmentioning

confidence: 99%

Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

et al. 2012

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“…Interestingly, a few degradation products were observed, which were excreted after 90 min, while the QDs remained in the blood or accumulated in liver and spleen. This study evidenced a prolonged circulation in the blood, with a half-residence time in the order of 2 h. Presently, a wide range of QDs are commercially available with different pending functions allowing their conjugation with [ 18 F]-prosthetic groups such as, e.g., [ 18 F]fluoroethyltosylate [98].…”

Section: Metal Sulfides Selenides and Telluridesmentioning

confidence: 70%

[18F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques

Deleuziere,

Benoist,

Quelven

et al. 2024

Molecules

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A wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient tools for the development of biomedical applications. However, bridging the gap between bench to bedside cannot be expected without a good knowledge of their behaviour in vivo, which can be obtained through non-invasive imaging techniques, such as positron emission tomography (PET). Their radiolabelling with [18F]-fluorine, a technique already well established and widely used routinely for PET imaging, with [18F]-FDG for example, and in preclinical investigation using [18F]-radiolabelled biological macromolecules, has, therefore, been developed. In this context, this review highlights the various nano-objects studied so far, the reasons behind their radiolabelling, and main in vitro and/or in vivo results obtained thereof. Then, the methods developed to introduce the radioelement are presented. Detailed indications on the chemical steps involved are provided, and the stability of the radiolabelling is discussed. Emphasis is then made on the techniques used to purify and analyse the radiolabelled nano-objects, a point that is rarely discussed despite its technical relevance and importance for accurate imaging. The pros and cons of the different methods developed are finally discussed from which future work can develop.

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“…The [ 18 F]fluoroethylation of quantum dots was performed by Patt et al in DMSO/borate buffer, and the reaction mixture was analyzed by size exclusion chromatography to determine the radiolabeling yield. 111 Even though the DMSO/buffer system is not ideal for the radiolabeling agent [ 18 F]FETs, [ 18 F]fluoroethylated quantum dots could be obtained with up to 5% overall RCY. Notably, amino-functionalized quantum dots gave a slightly better yield compared to their carboxylfunctionalized counterparts.…”

Section: F]fluoroethylation In Aqueous Mediummentioning

confidence: 99%

“…Notably, amino-functionalized quantum dots gave a slightly better yield compared to their carboxylfunctionalized counterparts. In comparison, 11 C-radiolabeling 111 For diagnosis of prostate cancer, the most promising target is the prostate-specific membrane antigen (PSMA) that is highly expressed in this disease. Besides 68 Ga-labeled peptides, other small amino acid conjugates based on the glutamate-urea-lysine moiety with high affinity to PSMA have been developed and radiolabeled with technetium-99m and fluorine-18.…”

Section: F]fluoroethylation In Aqueous Mediummentioning

confidence: 99%

2-[¹⁸F]Fluoroethyl tosylate – a versatile tool for building¹⁸F-based radiotracers for positron emission tomography

et al. 2015

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18F- and 11C-labelling of quantum dots with n.c.a. [18F]fluoroethyltosylate and [11C]methyliodide: a feasibility study

Cited by 11 publications

References 16 publications

Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

[18F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques

2-[¹⁸F]Fluoroethyl tosylate – a versatile tool for building¹⁸F-based radiotracers for positron emission tomography

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18F- and 11C-labelling of quantum dots with n.c.a. [18F]fluoroethyltosylate and [11C]methyliodide: a feasibility study

Cited by 11 publications

References 16 publications

Synthesis and In Vivo Evaluation of the Biodistribution of a 18F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

Synthesis and In Vivo Evaluation of the Biodistribution of a 18F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

[18F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques

2-[18F]Fluoroethyl tosylate – a versatile tool for building18F-based radiotracers for positron emission tomography

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Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

Synthesis and In Vivo Evaluation of the Biodistribution of a ¹⁸F-Labeled Conjugate Gold-Nanoparticle-Peptide with Potential Biomedical Application

2-[¹⁸F]Fluoroethyl tosylate – a versatile tool for building¹⁸F-based radiotracers for positron emission tomography