Abstract:The current consensus mechanism for hepatic ketogenesis posits a key role for islet hormones, with insulin inhibiting and glucagon stimulating formation of ketone bodies. In this model the action of glucagon in the presence of low portal insulin concentrations causes ketosis. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are effective for lowering glucose in diabetic patients, and cause a relative insulinopenia. These agents have been described to increase ketone production, and have been associated with… Show more
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